Construction of pH-Triggered DNA Hydrogels Based on Hybridization Chain Reactions

作     者：LI Yujie CHEN Jie DONG Yuanchen LIU Huajie LIU Dongsheng 

作者机构：Key Laboratory of Organic Optoelectronics&Molecular EngineeringMinistry of EducationDepartment of ChemistryTsinghua UniversityBeijing 100084P.R.China School of Chemical Science and EngineeringShanghai Research Institute for Intelligent Autonomous SystemsKey Laboratory of Advanced Civil Engineering MaterialsMinistry of EducationTongji UniversityShanghai 200092P.R.China Division of Physical BiologyCAS Key Laboratory of Interfacial Physics and TechnologyShanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201800P.R.China CAS Key Laboratory of ColloidInterface and Chemical ThermodynamicsInstitute of ChemistryChinese Academy of SciencesBeijing 100190P.R.China 

出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)

年 卷 期：2020年第36卷第2期

页      面：243-246页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

基　　金：Supported by the National Natural Science Foundation of China(Nos.21890731 21534007 21821001 21722310) 

主　　题：DNA hydrogel pH-Triggered Hybridization chain reaction Sol-gel phase transition 

摘      要：As a novel type of bio-functional material,DNA hydrogels have attracted more and more attention due to their successful applications in 3D cell culturing and tissue engineering for the designable and programmable ***,we have developed a pH-triggered DNA hydrogel based on a clamped hybridization chain reaction(C-HCR).In this system,a DNA switch was designed,which can release the initiator strand in a controllable way via the formation of the C-G-C4 triplex under the pH *** the pre-gelation solution is stable in neutral environment,the C-HCR will trigger the sol-gel transition as the pH decreased to *** strategy has endowed the DNA hydrogel with good controllability for triggering,which also shows potential in intellectual responsiveness to certain stimuli.