Non-enzymatic covalent modifications:a new link between metabolism and epigenetics

作     者：Qingfei Zheng Igor Maksimovic Akhil Upad Yael David Qingfei Zheng;Igor Maksimovic;Akhil Upad;Yael David

作者机构：Chemical Biology ProgramMemorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Tri-Institutional PhD Program in Chemical BiologyNew YorkNY 10065USA Department of PharmacologyWeill Cornell MedicineNew YorkNY 10065USA Department of PhysiologyBiophysics and Systems BiologyWeill Cornell MedicineNew YorkNY 10065USA 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2020年第11卷第6期

页      面：401-416页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 

基　　金：Work in the David lab is supported by R21 DA044767 CCSG core grant P30 CA008748 and SPORE P50-CA192937 from the National Institutes of Health.In addition work in the lab is supported by the Tri-institutional Therapeutic Discovery Institute the Mr.William H.Goodwin and Mrs.Alice Goodwin and the Commonwealth Foundation for Cancer Research and the Center for Experimental Therapeutics at MSKCC the Pershing Square Sohn Cancer Research Alliance and Cycle for Survival.Y.D.is a Josie Robertson Young Investigator.Additionally YD is supported by the Parker Institute for Cancer Immunotherapy and the Anna Fuller Cancer Research Foundation 

主　　题：epigenetics metabolism non-enzymatic modification chromatin human disease 

摘      要：Epigenetic modifications,including those on DNA and histones,have been shown to regulate cellular metabolism by controlling expression of enzymes involved in the corresponding metabolic *** turn,metabolic flux influences epigenetic regulation by affecting the biosynthetic balance of enzyme cofactors or donors for certain chromatin ***,non-enzymatic covalent modifications(NECMs)by chemically reactive metabolites have been reported to manipulate chromatin architecture and gene transcription through multiple ***,we summarize these recent advances in the identification and characterization of NECMs on nucleic acids,histones,and transcription factors,providing an additional mechanistic link between metabolism and epigenetics.