Association between NMDA receptor subunit 2b gene polymorphism and Alzheimer’s disease in Chinese Han population in Shanghai

作     者：陈超 李霞 王涛 王海红 傅燚 张雷 肖世富 

作者机构：上海交通大学医学院附属精神卫生中心上海200030 上海交通大学阿尔茨海默病诊治中心上海200030 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2010年第26卷第5期

页      面：395-400页

核心收录：

学科分类：1002[医学-临床医学] 100203[医学-老年医学] 10[医学] 

基　　金：supported by the Key Project of Shanghai Science and Technology Committee(No.08411951100,10ZR1425800) the National Major Special Project of Science and Technology of Ministry of Science and Technology,China(No.2008ZX09312-014,2008ZX09312-003) 

主　　题：Alzheimer’s disease N-methyl-D-aspartate receptor single nucleotide polymorphism 

摘      要：Objective N-methyl-D-aspartate（NMDA）receptor has been indicated to be involved in the pathogenesis of Alzheimer’s disease（AD）.The NMDA receptor subunit 2b（NR2B）has attracted more attention due to its characteristic distribution and selective reduction in AD *** present study aimed to explore the association between NMDA gene polymorphism and *** A total of 63 AD patients and 68 normal controls in Shanghai city were employed in this *** of C2664T variant（rs1806201）in the exon13 of GRIN2B gene was determined by gene sequencing. Results Among AD patients,15（23.6%）subjects were identified as C/C genotype,and 35（55.6%）were identified as C/T *** left 13（20.6%）subjects were identified as T/T *** normal controls,15（22.1%）subjects were identified as C/C genotype,39（57.4%）as C/T genotype and 14（20.6%）as T/T *** distribution frequency of neither GRIN2B C2664T genotype（P=0.895）nor allele（P=0.790）was significantly different between AD patients and normal controls,even when the subjects were stratified by gender and age of disease onset in AD *** The results suggest that there is no relation between GRIN2B C2664T polymorphism and AD in Chinese Han population of Shanghai City.