RBC Membrane Camouflaged Semiconducting Polymer Nanoparticles for Near-Infrared Photoacoustic Imaging and Photothermal Therapy

作     者：Dongye Zheng Peiwen Yu Zuwu Wei Cheng Zhong Ming Wu Xiaolong Liu Dongye Zheng;Peiwen Yu;Zuwu Wei;Cheng Zhong;Ming Wu;Xiaolong Liu

作者机构：School of Life SciencesFujian Agriculture and Forestry UniversityFuzhou 350002People’s Republic of China The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian ProvinceMengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhou 350025People’s Republic of China Key Laboratory of Design and Assembly of Functional NanostructuresFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002People’s Republic of China Mengchao Med?X CenterFuzhou UniversityFuzhou 350116People’s Republic of China Department of ChemistryHubei Key Lab on Organic and Polymeric Optoelectronic MaterialsWuhan UniversityWuhan 430072People’s Republic of China 

出 版 物：《Nano-Micro Letters》 (纳微快报（英文版）)

年 卷 期：2020年第12卷第7期

页      面：218-234页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0836[工学-生物工程] 0702[理学-物理学] 

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.61727823,51873160) the joint research project of Health and Education Commission of Fujian Province(Grant No.2019-WJ-20) 

主　　题：Semiconducting conjugated polymer nanoparticles Red blood cell membrane camouflage Deep tumor penetration Photoacoustic imaging Photothermal therapy 

摘      要：Semiconducting conjugated polymer nanoparticles(SPNs)represent an emerging class of phototheranostic materi-als with great promise for cancer *** this report,low-bandgap electron donoracceptor(DA)-conjugated SPNs with sur-face cloaked by red blood cell membrane(RBCM)are developed for highly e ective photoacoustic imaging and photothermal *** resulting RBCM-coated SPN(SPN@RBCM)displays remarkable near-infrared light absorption and good photosta-bility,as well as high photothermal conver-sion e ciency for photoacoustic imaging and photothermal ***,due to the small size(5 nm),SPN@RBCM has the advantages of deep tumor penetration and rapid clearance from the body with no appreciable *** RBCM endows the SPNs with prolonged systematic circulation time,less reticuloendothelial system uptake and reduced immune-recognition,hence improving tumor accumulation after intravenous injection,which provides strong photoacoustic signals and exerts excellent photothermal therapeutic e ***,this work provides a valuable paradigm for safe and highly e cient tumor pho-toacoustic imaging and photothermal therapy for further clinical translation.