Synergistic antibacterial activity of physical-chemical multi-mechanism by TiO2 nanorod arrays for safe biofilm eradication on implant

作     者：Xiangyu Zhang Guannan Zhang Maozhou Chai Xiaohong Yao Weiyi Chen Paul KChu 

作者机构：Laboratory of Biomaterial Surfaces&InterfacesInstitute of New Carbon MaterialsTaiyuan University of TechnologyTaiyuan030024China College of Biomedical EngineeringTaiyuan University of TechnologyTaiyuan030024China Second Hospital of Shanxi Medical UniversityTaiyuan030024China Department of PhysicsDepartment of Materials Science and EngineeringDepartment of Biomedical EngineeringCity University of Hong KongTat Chee AvenueKowloonHong KongChina 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2021年第6卷第1期

页      面：12-25页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 070304[理学-物理化学(含∶化学物理)] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 

基　　金：the National Natural Science Foundation of China(31700834 and 11632013) Major Projects in Research and Development of Shanxi(Projects of International Cooperation,201803D421090) Fund for Shanxi“1331 Project”Key Innovative Research Team(PY201809) Hong Kong Research Grants Council(RGC)General Research Funds(GRF)(CityU 11205617) Guangdong-Hong Kong Technology Cooperation Funding Scheme(TCFS)GHP/085/18SZ(CityU 9440230) 

主　　题：Titanium implants TiO2 nanorod Anti-biofilm Physical insertion Light-triggered therapy 

摘      要：Treatment of implant-associated infection is becoming more challenging,especially when bacterial biofilms form on the surface of the *** multi-mechanism antibacterial methods to combat bacterial biofilm infections by the synergistic effects are superior to those based on single modality due to avoiding the adverse effects arising from the *** this work,TiO2 nanorod arrays in combination with irradiation with 808 nearinfrared(NIR)light are proven to eradicate single specie biofilms by combining photothermal therapy,photodynamic therapy,and physical killing of *** TiO2 nanorod arrays possess efficient photothermal conversion ability and produce a small amount of reactive oxygen species(ROS).Physiologically,the combined actions of hyperthermia,ROS,and puncturing by nanorods give rise to excellent antibacterial properties on titanium requiring irradiation for only 15 min as demonstrated by our experiments conducted in vitro and in *** importantly,bone biofilm infection is successfully treated efficiently by the synergistic antibacterial effects and at the same time,the TiO2 nanorod arrays improve the new bone formation around *** this protocol,besides the biocompatible TiO2 nanorod arrays,an extra photosensitizer is not needed and no other ions would be *** findings reveal a rapid bacteria-killing method based on the multiple synergetic antibacterial modalities with high biosafety that can be implemented in vivo and obviate the need for a second *** concept and antibacterial system described here have large clinical potential in orthopedic and dental applications.