Applications of mass spectrometry to signal transduction

作     者：Resing, KA Ahn, NG 

作者机构：Univ Colorado Dept Chem & Biochem Boulder CO 80309 USA Univ Colorado Howard Hughes Med Inst Boulder CO 80309 USA 

出 版 物：《PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY》 (生物物理学与分子生物学进展)

年 卷 期：1999年第71卷第3-4期

页      面：501-523页

核心收录：

学科分类：0710[理学-生物学] 071011[理学-生物物理学] 07[理学] 

主　　题：生物化学/方法 脂类/分析 脂类/生理学 质谱分析法/仪器和设备 质谱分析法/方法 蛋白质构象 蛋白质折叠 蛋白质加工 转译后 蛋白质类/化学 蛋白质类/代谢 信号传导 动物 人类 

摘      要：Advances in mass spectrometry instrumentation, protocols for sample handling, and computational methods provide powerful new approaches to solving problems in analytical biochemistry. This review summarizes recent work illustrating ways in which mass spectrometry has been used to address questions relevant to signal transduction. Rather than encompass all of the instruments or methodologies that might be brought to bear on these problems, we present an overview of commonly used techniques, promising new methodologies, and some applications. (C) 1999 Elsevier Science Ltd. All rights reserved.