Overcoming bacterial physical defenses with molecule-like ultrasmall antimicrobial gold nanoclusters

作     者：Kaiyuan Zheng Magdiel ISetyawati David Tai Leong Jianping Xie 

作者机构：Department of Chemical and Biomolecular EngineeringNational University of Singapore4 Engineering Drive 4117585Singapore School of Materials Science and EngineeringNanyang Technological University50 Nanyang Avenue639798Singapore 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2021年第6卷第4期

页      面：941-950页

核心收录：

学科分类：07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学] 

基　　金：This work was financially supported by Ministry of Education Singapore under Grant R-279-000-580-112 and R-279-000-538-114 

主　　题：Gold nanoclusters Gold nanoparticles Antimicrobial agents Molecule-like properties Size effects 

摘      要：The size of metal nanoparticles(NPs)is crucial in their biomedical *** abundant studies on the size effects of metal NPs in the range of 2-100 nm have been conducted,the exploration of the ultrasmall metal nanoclusters(NCs)of~1 nm in size with unique features is quite *** synthesize three different sized gold(Au)NCs of different Au atom numbers and two bigger sized Au NPs protected by the same ligand to study the size influence on antimicrobial *** ultrasmall Au NCs can easily traverse the cell wall pores to be internalized inside bacteria,inducing reactive oxygen species generation to oxidize bacterial membrane and disturb bacterial *** explains why the Au NCs are antimicrobial while the Au NPs are non-antimicrobial,suggesting the key role of size in antimicrobial ***,in contrast to the widely known size-dependent antimicrobial properties,the Au NCs of different atom numbers demonstrate molecule-like instead of size-dependent antimicrobial behavior with comparable effectiveness,indicating the unique molecule-like feature of ultrasmall Au *** the bacterial defenses at the wall with ultrasmall Au NCs changes what was previously believed to harmless to the bacteria instead to a highly potent agent against the bacteria.