Hippo signaling:bridging the gap between cancer and neurodegenerative disorders

作     者：Neha Gogia Anuradha Venkatakrishnan Chimata Prajakta Deshpande Aditi Singh Amit Singh Neha Gogia;Anuradha Venkatakrishnan Chimata;Prajakta Deshpande;Aditi Singh;Amit Singh

作者机构：Department of BiologyUniversity of DaytonDaytonOHUSA Medical CandidateUniversity of Toledo College of Medicine and Life SciencesToledoOHUSA Premedical ProgramUniversity of DaytonDaytonOHUSA Center for Tissue Regeneration and Engineering at Dayton(TREND)University of DaytonDaytonOHUSA The Integrative Science and Engineering CenterUniversity of DaytonDaytonOHUSA Center for Genomic Advocacy(TCGA)Indiana State UniversityTerre HauteINUSA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2021年第16卷第4期

页      面：643-652页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：The authors are supported by the University of Dayton Graduate program of Biology This work was supported by NIH1R15GM124654-01 from the National Institutes of Health,Schuellein Chair Endowment Fund,and start-up support from the University of Dayton(to Amit S) 

主　　题：animal models cell death mechanisms cell-signaling chemical inhibitors Drosophila eye Hippo pathway neurodegeneration neurological diseases therapeutic targets 

摘      要：During development,regulation of organ size requires a balance between cell proliferation,growth and cell *** of these fundamental processes can cause a variety of *** cell proliferation results in cancer whereas excessive cell death results in neurodegenerative *** signaling pathways known-to-date have a role in growth *** them,evolutionarily conserved Hippo signaling pathway is unique as it controls both cell proliferation and cell death by a variety of mechanisms during organ sculpture and ***,a complex process of progressive death of neuronal population,results in fatal disorders with no available cure to *** normal development,cell death is required for sculpting of an ***,aberrant cell death in neuronal cell population can result in neurodegenerative *** pathway has gathered major attention for its role in growth regulation and cancer,however,other functions like its role in neurodegeneration are also emerging *** review highlights the role of Hippo signaling in cell death and neurodegenerative diseases and provide the information on the chemical inhibitors employed to block Hippo *** Hippo mediated cell death mechanisms will aid in development of reliable and effective therapeutic strategies in future.