Myeloid-derived suppressor cells and regulatory T cells share common immunoregulatory pathways-related microRNAs that are dysregulated by acute lymphoblastic leukemia and chemotherapy

作     者：Salem, Mohamed Labib Zidan, Abdel-Aziz A. El-Naggar, Randa Ezz El-Din Saad, Mohamed Attia El-Shanshory, Mohamed Bakry, Usama Zidan, Mona 

作者机构：Tanta Univ Fac Sci Dept Zool Immunol & Biotechnol Unit Tanta Egypt Tanta Univ Teaching Hosp Ctr Excellence Canc Res Tanta Egypt Damanhur Univ Fac Sci Dept Zool Damanhur Egypt Tanta Univ Fac Med Dept Clin Pathol Tanta Egypt Tanta Univ Fac Med Dept Pediat Tanta Egypt 57357 Children Canc Hosp Genom Res Program Cairo Egypt 57357 Children Canc Hosp Immunol Res Program Cairo Egypt 

出 版 物：《HUMAN IMMUNOLOGY》 (人类免疫学)

年 卷 期：2021年第82卷第1期

页      面：36-45页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：Science and Technology Development Fund  Ministry of Scientific Research Egypt 

主　　题：Acute lymphoblastic leukemia MicroRNAs Immunoregulatory signaling pathways Myeloid-derived suppressor cells T regulatory cells 

摘      要：Background: Relapse remains a critical challenge in children with acute lymphoblastic leukemia (ALL). The emergence of immunoregulatory cells, including myeloid-derived suppressor cells (MDSCs), and T regulatory (T-reg) cells, has been considered one potential mechanism of relapse in children with ALL. Aim: This study aimed to address the microRNAs (miRNAs) related to MDSCs and T-reg cells and to explore their targeted immunoregulatory pathways. Methods: Affymetrix microarray was used for global miRNA profiling in B-ALL pediatric patients before, during, and after induction of chemotherapy. Bioinformatics analysis was performed on MDSCs and T-reg cells-related dysregulated miRNAs, and miR-Pathway analysis was performed to explore their targeted immunoregulatory pathways. Results: 516 miRNAs were dysregulated in ALL patients as compared to the healthy donor. Among them, 13 miRNAs and 8 miRNAs related to MDSCs and T-reg cells, respectively, were common in all patients. Besides, 12 miRNAs were shared between MDSCs and T-reg cells;4 of them were common in all patients. Four immune-related pathways;TNF, TGF-beta, FoxO, and Hippo were found implicated. Conclusion: Our pilot study concluded certain miRNAs related to MDSCs and T-reg cells, these miRNAs were linked to immunoregulatory pathways. Our results open avenues for testing those miRNA as molecular biomarkers for the immunosuppressive tumor microenvironment. (c) 2020 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.