A smart hydrogel for on-demand delivery of antibiotics and efficient eradication of biofilms

作     者：Jingjing Hu Chenglin Zhang Lei Zhou Qianyu Hu Yanlong Kong Dianwen Song Yiyun Cheng Yadong Zhang 胡婧婧;张成林;周磊;胡倩瑜;孔彦龙;宋滇文;程义云;张亚东

作者机构：Shanghai Key Laboratory of Regulatory BiologySchool of Life SciencesEast China Normal UniversityShanghai 200241China Department of OrthopeticsShanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200080China Department of OrthopaedicsFengxian Hospital Affiliated to Anhui University of Science and TechnologyShanghai 201499China Department of OrthopaedicsFengxian Hospital Affiliated to Southern Medical UniversityShanghai 201499China 

出 版 物：《Science China Materials》 (中国科学（材料科学（英文版）)

年 卷 期：2021年第64卷第4期

页      面：1035-1046页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 081702[工学-化学工艺] 08[工学] 0817[工学-化学工程与技术] 10[医学] 

基　　金：the National Key R&D Program of China Synthetic Biology Research(2019YFA0904500) the National Natural Science Foundation of China(21725402 and51672191) the Natural Science Foundation of Shanghai(19ZR1415600) 

主　　题：biofilm smart hydrogels antibacterial enzyme antibiotics 

摘      要：Biofilm-associated infections are difficult to treat in the clinics because the bacteria embedded in biofilm are ten to thousand times more resistant to traditional antibiotics than planktonic ***,a smart hydrogel comprised of aminoglycoside antibiotics,pectinase,and oxidized dextran was developed to treat local biofilm-associated *** primary amines on aminoglycosides and pectinase were reacted with aldehyde groups on oxidized dextran via a pH-sensitive Schiff base linkage to form the *** bacterial infection,the increased acidity triggers the release of both pectinase and aminoglycoside *** released pectinase efficiently degrades extracellular polysaccharides surrounding the bacteria in biofilm,and thus greatly sensitizes the bacteria to *** smart hydrogel efficiently eradicated biofilms and killed the embedded bacteria both in vitro and in *** study provides a promising strategy for the treatment of biofilm-associated infections.