Cyanobacteria-based near-infrared light-excited self-supplying oxygen system for enhanced photodynamic therapy of hypoxic tumors

作     者：Yinghua Zhang Huifang Liu Xinyue Dai Hang Li Xiaohan Zhou Shizhu Chen Jinchao Zhang Xing-Jie Liang Zhenhua Li Yinghua Zhang;Huifang Liu;Xinyue Dai;Hang Li;Xiaohan Zhou;Shizhu Chen;Jinchao Zhang;Xing-Jie Liang;Zhenhua Li

作者机构：College of Chemistry&Environmental ScienceAnalytical Chemistry Key Laboratory of Hebei ProvinceChemical Biology Key Laboratory of Hebei ProvinceHebei UniversityBaoding071002China Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of EducationInstitute of Life Science and Green DevelopmentHebei UniversityBaoding071002China College of Pharmaceutical ScienceKey Laboratory of Pharmaceutical Quality Control of Hebei ProvinceHebei UniversityBaoding071002China Beijing Pharmaceutical Group Company LimitedBeijing100101China The National Institutes of Pharmaceutical R&D Co.Ltd.China Resources Pharmaceutical Group LimitedBeijing102206China CAS Key Laboratory for Biological Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and TechnologyBeijing100190China 

出 版 物：《Nano Research》 (纳米研究（英文版）)

年 卷 期：2021年第14卷第3期

页      面：667-673页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was supported by National Natural Science Foundation of China(Nos.21977024,21601046,and 31971304) Advanced Talents Incubation Program of the Hebei University(No.801260201020) Funded by China Postdoctoral Science Foundation(No.2019M650558) Beijing Postdoctoral Research Foundation and Beijing Chaoyang District Postdoctoral Research Fundation.We are grateful to Medical Comprehensive Experimental Center of Hebei University for the animal experiment 

主　　题：self-supplying oxygen cyanobacteria hypoxic tumor photodynamic therapy upconversion nanoparticles 

摘      要：Tumor hypoxia has been considered to induce tumor cell resistance to radiotherapy and anticancer chemotherapy,as well as predisposing for increased tumor ***,strategies for the eradication of the hypoxic tumor are highly *** therapy(PDT)is a new technique that can be used to treat tumors using laser irradiation to photochemically activate a *** to traditional radiotherapy and chemotherapy,photodynamic therapy has many advantages,such as good selectivity,low toxicity,and less trauma and ***,PDT is oxygen-dependent,and the lack of oxygen in hypoxic tumors renders photodynamic therapy ***,the earliest photosynthetic oxygen-generating organisms,can utilize water as an electron donor to reduce CO_(2) into organic carbon compounds along with continuously releasing oxygen under *** by this,herein,cyanobacteria were used as a living carrier of photosensitizer conjugated upconversion nanoparticles(UCNP)to construct a self-supplying oxygen PDT *** in the PDT efficiency for hypoxic tumors can be achieved as a result of in situ oxygen production by cyanobacteria under near-infrared(NIR)light using UCNP as a light harvesting antenna.A successful demonstration of this concept would be of great significance and could open the door to a new generation of carrier systems in the field of hypoxia-targeted drug transport platforms.