Study on the surface-modification of nano-hydroxyapatite with lignin and the corresponding nanocomposite with poly (lactide-co-glycolide)

作     者：Haojie Ding Liuyun Jiang Chunyan Tang Shuo Tang Bingli Ma Na Zhang Yue Wen Yan Zhang Liping Sheng Shengpei Su Xiang Hu Haojie Ding;Liuyun Jiang;Chunyan Tang;Shuo Tang;Bingli Ma;Na Zhang;Yue Wen;Yan Zhang;Liping Sheng;Shengpei Su;Xiang Hu

作者机构：National&Local Joint Engineering Laboratory for New Petro-Chemical Materials and Fine Utilization of ResourcesCollege of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha 410081China Key Laboratory of Sustainable Resources Processing and Advanced MaterialsCollege of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha 410081China Key Laboratory of Chemical Biology&Traditional Chinese Medicine Research(Ministry of Education)College of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha 410081China State Key Laboratory Developmental Biology of Freshwater FishSchool Life ScienceHunan Normal UniversityChangsha 410081China 

出 版 物：《Frontiers of Chemical Science and Engineering》 (化学科学与工程前沿（英文版）)

年 卷 期：2021年第15卷第3期

页      面：630-642页

核心收录：

学科分类：08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：the support of the Science and Technology Project of Changsha(Grant No.kq1907132) Natural Science Foundation of Province(Grant No.2020JJ4430) Opening Found of Key Laboratory of Chemical Biology&Traditional Chinese Medicine Research(Ministry of Education of China) Hunan Normal University(Grant No.KLCBTCMR201812) Hunan Engineering Laboratory for Preparation Technology of Poly(vinyl alcohol)Fiber Material Huaihua University(Grant No.HGY201812) the National Natural Science Foundation of China(Grant No.51803055) Hunan Provincial Key Research and Development Program(Grant No.2018GK2062) 

主　　题：nanocomposite poly(lactide-co-glycolide) hydroxyapatite mechanical property 

摘      要：To obtain nano-hydroxyapatite/poly(lactideco-glycolide)(n-HA/PLGA)nanocomposite with superior mechanical properties,here,lignin was chosen to surfacemodify for n-HA through co-precipitation *** different reaction conditions of reaction time,phosphorus source,and the lignin addition amount were studied by fourier transformation infrared spectra,X-ray diffraction,the intuitionistic dispersion experiment,transmission electron microscope and thermal gravimetric *** reaction mechanism and the best appropriate reaction condition were *** importantly,the results of electromechanical universal tester,scanning electron microscope,differential scanning calorimetric analyzer,polarized optical microscopy and dynamic mechanical analysis confirmed that the obtained n-HA could greatly increase the mechanical strength of PLGA,owing to the excellent dispersion and promotion crystallization ***,in vitro cell culture experimental results indicated that the n-HA surface-modified by lignin was favorable to improve the cell biocompatibility of *** study suggested that the introduction of lignin was a novel method to acquire a highly dispersed n-HA,which would provide a new idea to achieve the n-HA/PLGA nanocomposite as bone materials in future,and it would pave the way towards a new application of lignin in biomedical field.