Fluid-structure interaction studies on the cardiovascularhemodynamics of a mitral valve

作     者：Moghaddaszade Kermani, Ahmad 

作者单位：University of Victoria 

学位级别：doctor

导师姓名：Suleman,Afzal,eadvisorOshkai,Peter,eadvisor

授予年度：2011年

主      题：Fluid-Structure Interaction Computational Fluid Dynamics Heart Valve 

摘      要：The thesis presents a fluid-structure interactionstudies on the hemodynamics of blood flow in the left ventricle andthrough the mitral valve. The virtual model consists of amathematical model of the left ventricle coupled with a complex andstructurally flexible bi-leaflet valve representing the mitralopening. The mitral valve is a bicuspid valve with anterior andposterior leaflets and it regulates unidirectional blood flow fromthe left atrium to the left ventricle in the diastole phase. Theleaflets are made of chordae, annulus and papillary muscles. Thegoal of this study is to provide biomedical engineers and clinicalphysicians with a virtual laboratory tool to understand thedynamics of blood flow in a diseased heart and aid in the design ofnovel artificial heart valves. To this end, the simulation studiespresent an increasingly complex model of the heart to evaluate thevortex ring formation and evolution of the diastole phase in theleft ventricle; and to characterize the septal-anterior motion in adiseased heart with obstructive hypertrophic ***, in collaboration with an industrial partner, thefluid-structure modeling framework was used to evaluate theperformance of a new accelerated artificial valvetester.%%%%Graduate