Building user interactive capabilities for image-based modeling of patient-specific biological flows in single platform

作     者：Liza Shrestha 

作者单位：University of Iowa 

学位级别：博士

导师姓名：Vigmostad, Sarah C.

授予年度：2016年

主      题：Aortic dissection CFD Image based modeling segmentation wall shear stress 

摘      要：In this work, we have developed user interactive capabilities that allow us to perform segmentation and manipulation of patient-specific geometries required for Computational Fluid Dynamics (CFD) studies, entirely in image domain and within a single platform of IAFEMesh . Within this toolkit we have added commonly required manipulation capabilities for performing CFD on segmented objects by utilizing libraries like ITK, VTK and KWWidgets. With the advent of these capabilities we can now manipulate a single patient specific image into a set of possible cases we seek to study; which is difficult to do in commercially available software like VMTK, Slicer, MITK etc. due to their limited manipulation capabilities. Levelset representation of the manipulated geometries can be simulated in our flow solver (SCIMITAR-3D) without creating any surface or volumetric mesh. This image-levelset-flow framework offers few advantages. 1) We don t need to deal with the problems associated with mesh quality, edge connectivity related to mesh models, 2) and manipulations like boolean operation result in smooth, physically realizable entities which is challanging in mesh domain. We have validated our image-levelset-flow setup with the known results from previous studies. We have modified the algorithm by Krissian et al. and implemented it for the segmentation of Type-A aortic dissection. Finally, we implemented these capabilities to study the hemodynamics in Type-A aortic dissection. Our image based framework is a first of its kind and the hemodynamic study of Type-A dissection too is first study onto the best of our knowledge.