AMPK ACTIVATORS

专利申请号：US17846819

公 开 号：US20220340599(A1)

发 明 人：Iyassu SEBHAT Shuwen HE 

申 请 日：20221027

公 开 日：20220622

专利主分类号：C07D 519/ 00

摘      要：This disclosure is directed, at least in part, to AMPK activators useful for the treatment of conditions or disorders associated with AMPK. In some embodiments, the condition or disorder is associated with the gut-brain axis. In some embodiments, condition or disorder is associated with systemic infection and inflammation from having a leaky gut barrier. In some embodiments, the AMPK activators are gut-restricted compounds. In some embodiments, the AMPK activators are agonists, super agonists, full agonists, or partial agonists.