Three new saponins(1-3)and a new natural product(4)together with six known compounds were isolated from the whole plant of Reineckia *** structures were determined by detailed analysis of their 1D and 2D NMR spectra,M...
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Three new saponins(1-3)and a new natural product(4)together with six known compounds were isolated from the whole plant of Reineckia *** structures were determined by detailed analysis of their 1D and 2D NMR spectra,MS and comparison with *** addition,all the isolated compounds were evaluated for their inhibitory activity on LPS-stimulated nitric oxide(NO)production in RAW 264.7 *** 1-4 inhibited LPS stimulated NO production in RAW 264.7 macrophages with IC50 values of 37.5 μM,31.4 μM,34.6 μM,56.1 μM,*** 5-10 showed inhibitory activities with IC50 values ranging from 20.3 to 42.9 μM.
Objective It is the first time that the near-infrared spectroscopy(NIRS)and chemometrics methods were used to establish a quantitative model for the determination of the content of Shengmaxinside I in the honey-fried ...
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Objective It is the first time that the near-infrared spectroscopy(NIRS)and chemometrics methods were used to establish a quantitative model for the determination of the content of Shengmaxinside I in the honey-fried processing of Rhizoma *** HPLC method was used to determine the content of Shengmaxinside I,and NIRS of the honey-fried processing of Rhizoma Cimicifugae samples from different batches of different origins were collected by TQ Analyst 8.0 analysis software using Partial Least Squares Regression(PLSR)method was used to establish a near-infrared quantitative model and validate *** The correlation coefficient R was 0.97234,root mean square error of calibration(RMSEC)was 0.0253,validating the model with a validation set,root mean square error of prediction(RMSEP)was *** The method is convenient and efficient,and the model established by experiments has good prediction ability,which is used for the rapid determination of the content of Shengmaxinside I in the honey-fried processing of Rhizoma Cimicifugae for the first time.
Background:Many studies have shown that Andrographis paniculata(Burm.f.)Nees has a good antitumor effect,but poor solubility in water and poor bioavailability hinder the modernization of ***: To formulate the effectiv...
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Background:Many studies have shown that Andrographis paniculata(Burm.f.)Nees has a good antitumor effect,but poor solubility in water and poor bioavailability hinder the modernization of ***: To formulate the effective parts(mainly diterpene lactones)ofAndrographis paniculata(AEP)into targeting drug delivery system,a series of poly(ethylene glycol)-poly(D.L-lactic acid)(mPEG-PLA)with different ratio of hydrophilic and hydrophobic segment was synthetized to encapsulate *** micelles were prepared by a simple solvent-evaporation *** to the loading capacity,the best polymer was ***-PLA micelles were characterized in terms of drug entrapping efficiency,loading capacity,size,the crystalline state of AEP,stability and release ***,the cytotoxicity of micelles on mouse breast cancer 4T-1 was ***: These micelle(mPEG-PLA-AEP)particles had a size of(92.84±5.63)nm and a high entrapping efficiency and loading capacity of(91.00±11.53)%and(32.14±3.02)%(w/w),*** powder DSC showed that drugs were well encapsulated in the core of ***-PLA-AEP had a good stability against salt dissociation,protein adsorption and anion substitution and the solubility of andrographolide(AG)and 14-deoxy-11,12-didehydroandrographolide(DDAG)in AEP increased 4.51 times and 2.12 times in water,and the solubility of DAG showed no ***-PLA-AEP had the same release profile in different dissolution *** testing in vitro demonstrated that mPEG-PLA-AEP exhibited higher cell viability inhibition in mouse breast cancer 4T-1 than free ***: mPEG-PLA micelles offer a promising alternative for TCM therapy with higher solubilityand improved antitumor effect.
Intracereb ral hemorrhagic stroke(ICH)is a fatal subtype of stroke,with crucial impact on public health,surgical removal of the hematoma as an early-stage treatment for ICH can 't improve lon g-term prognosis *** ...
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Intracereb ral hemorrhagic stroke(ICH)is a fatal subtype of stroke,with crucial impact on public health,surgical removal of the hematoma as an early-stage treatment for ICH can 't improve lon g-term prognosis *** gxue Tongyu Prescription(L P)including eight medicines with comprehensive therapeutic strategies,as Traditional Chinese Medicine,might decrease the occurrence of adverse effects in clinical treating ICH through re duce the secondary brain edem a,promote the hematoma ab sorption,alleviate the inflamm atory respon se an d neurological dam ***,we found that LP has integrated therapeutic effect on ICH due to activities of neurotransmitters,anti-in flam matory,an tioxidant and anti-apoptosis based on network dissection and experimen tal verification on hy pertensive rats and glutamate-in duced PC12 ***,many kinds of signal pathways during the occurren ce process of ICH involved in LP multi-comp ound t related targets were an alyze d by the Clue Go assay,the compounds in LP can activate PI3K/AKT pa thway against glut amate-induced neuron injury and *** last,we foun d that mu lti-compound from some herb pa irs or single herb in LP on ICH had a sy nergistic interaction on the gl utamate-induced PC12 cell by Factorial Design,some compound compatibility as combination of GRg1a nd GRb1,Taurin e and Geniposide at half-dosage respectively,had synergistic effect on PI3K/AKT *** a certain extent,this result also supports this conclusion that the integer therapeutic effect of multi-comp ound in TCM at low concentration wa s valid.
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