The metabolism of gentiopicroside in vivo was studied for the first time by LC/MS following picolinoyl *** of erythrocentaurin, one of the main in vitro metabolites of GPS by intestinal bacteria, with liver microsome ...
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The metabolism of gentiopicroside in vivo was studied for the first time by LC/MS following picolinoyl *** of erythrocentaurin, one of the main in vitro metabolites of GPS by intestinal bacteria, with liver microsome indicated that gentiopicroside maybe metabolized to the final metabolite 3, 4-dihydro-5-(hydroxymethyl) isochroman-1-one in *** hydrolyzation with sulfatase, 3, 4-dihydro-5-(hydroxymethyl) isochroman-1-one was successfully detected in rat plasma after oral administration of gentiopicroside by LC/MS following picolinoyl derivatization.4-methoxyphenyl methanol was used as the internal standard to quantify 3, 4-dihydro-5-(hydroxymethyl) isochroman-1-one in rat *** metabolic pathway of gentiopicroside in rats was *** monoterpene compound gentiopicroside was found to be metabolized to dihydroisocoumarin which maybe responsible for the pharmacological effect of gentiopicroside.
Statistical experimental designs provided by Design-Expert software were applied to optimize the extraction technology of total tannins from *** L..A "Box-Behnken" Design was employed to evaluate the effects...
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Statistical experimental designs provided by Design-Expert software were applied to optimize the extraction technology of total tannins from *** L..A "Box-Behnken" Design was employed to evaluate the effects of different components in the medium.A series of singlefactor experiments were conducted to investigate the effects of extraction time, methanol concentration, solid-liquid ratio and extraction times on the yield of total *** or no-linear mathematic models were used to estimate the relationship between independent and dependent *** the contents of total tannins in *** *** were collected from different places by the optimum extraction *** optimal values of the above parameters were the concentration of Methanol of 47%, supersonic extraction time of 45 min, and the solid-liquid ratio of 52: *** the optimized conditions, the experimental value of total tannins was 10.81%.The range of total tannins content of *** *** different areas was 4.42~10.29%.The total tannins content difference to be significantly different regions, The factors of areas should be fully considered when used as medicine.
Type 1 diabetes is also called insulin-dependent diabetes or autoimmune diabetes means that the body destroys its own insulin-producing *** particular, the pancreas produces insufficient insulin (insulin deficiency ab...
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Type 1 diabetes is also called insulin-dependent diabetes or autoimmune diabetes means that the body destroys its own insulin-producing *** particular, the pancreas produces insufficient insulin (insulin deficiency absolute or relative to the needs of the body) or because cells do not use insulin, increases blood glucose and urine *** 1 diabetes tends to occur in young, usually under 30 years of *** is a risk factor to increase the occurrence and severity of cardiovascular *** to statistics, cardiovascular complications are the leading cause of death of 3/4 of the number of diabetic patients over 40 years *** (Sesamumindicum) is one of nature medicine has been know with many function for good ***-a lignan extracted from the sesame seed -have many beneficial effects such as hypoglycemia, ameliorate lipid metabolism, antioxidant and hypolipidemic activity, reduced cholesterol, and exhibited anti-inflammatory *** administration of sesamin extract for four weeks (100 mg / kg BW and 200 mg / kg BW) was slightly improved blood glucose levels and body weight in rats with type 1 *** it was significantly ameliorated heart rate, blood pressure and QT interval in male diabetes *** indicated that sesamin has a positive effect in reducing cardiovascular complications in diabetic subj ects.
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