目的：建立高效液相色谱飞行时间串联质谱(high performance liquid chromatography/time-of-flight mass spectrometry, H PLC-Q-TOF-MS-MS)快速检测降压类中成药中24种非法添加的化学物质的方法.方法：样品经甲醇超声提取后,采用高效...
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目的：建立高效液相色谱飞行时间串联质谱(high performance liquid chromatography/time-of-flight mass spectrometry, H PLC-Q-TOF-MS-MS)快速检测降压类中成药中24种非法添加的化学物质的方法.方法：样品经甲醇超声提取后,采用高效液相色谱/质谱测定法,以Poroshell 120 EC-C182.7μm 2.1* 100mm为分析柱,0.05％甲酸溶液-甲醇为流动相,流速0.3 ml·min-1进行梯度洗脱,电喷雾电离(ESI)正离子模式进行质谱数据采集,对降压类中成药中24种违法添加化学物质进行筛选分析.结果：建立了快速分离检测降压类中成药中24种非法添加物质的测定方法,24种违法添加物质的色谱图分离度良好,检测限均小于1ng,质谱分辨率符合鉴别要求.结论：该方法专属性强、灵敏度高,快捷,可作为减压类中成药中非法添加药物的有效检测方法.
Long term goal:New mechanisms and novel therapies for fibrosis The Yin & Yang and the balance of TGF-β/Smad signaling in renal ***-β/Smad signaling is a key pathway leading to *** imbalance of Smad signals cause...
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Long term goal:New mechanisms and novel therapies for fibrosis The Yin & Yang and the balance of TGF-β/Smad signaling in renal ***-β/Smad signaling is a key pathway leading to *** imbalance of Smad signals causes tissue *** Smad 3 a key mediator in tissue fibrosis? Disrupted Smad3 Prevents Ana II-induced *** Smad3 Prevents Ana II-Mediated renal fibrosis.
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