Alzheimer's disease (AD) is the most common type of neurodegenerative disease in the elderly *** (ChE) plays an important role in the pathogenesis of AD.A growing body of research suggests that cholinesterase inhi...
详细信息
Alzheimer's disease (AD) is the most common type of neurodegenerative disease in the elderly *** (ChE) plays an important role in the pathogenesis of AD.A growing body of research suggests that cholinesterase inhibitors (ChEI) extracted from plants are able to significantly increase extracellular ChE levels with minimal side *** screened for naturally occurring ChEI in tráditional Chinese medicines (CM) in order to find effective and safe ChEI..In this study, 56 crude extracts(solubilized with Petroleum ether, ethanol, ethyl acetate, and aqueous solvents) were obtained from 14 CM *** crude extracts were examined for ChEI activity using a plate-based colorimetric *** was found that the CM extracts from Saussurea costus ***., Reynoutria japonica (Houtt.), Sophora tonkinensis Gagnep., Dryopteris crassirhizoma Nakai, and Paederia scandens [(Lour.) Merr.] significantly inhibited ChE activity at a concentration of 50 μg/***-dependent inhibitory assays were also performed using extracts that exhibited significant *** IC50 of the CM extracts for the inhibition of BuChE and AChE were approximately 11.290-42.027 and 16.00-27.04 μrn/ml, *** experimental results demonstrated that Reynoutriajaponica *** Saussurea costus (Falc.) Lipsch extracts can be used as inhibitors of both AChE and BuChE during treatment of ***, CM can serve as a useful source of ChE *** findings of this study indicate that further investigation into the pharmacologic activities of traditional Chinese medicines is warranted..
暂无评论