Many foods and herbs are experientially classified into different commodity grades in commercial *** to the hypertoxic herb-aconite, such large one was considered as better quality and lower ***, this experiential cla...
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Many foods and herbs are experientially classified into different commodity grades in commercial *** to the hypertoxic herb-aconite, such large one was considered as better quality and lower ***, this experiential classification lacks of scientific basis, and is not benefit for the market transactions and drug *** this paper, we focused on the relationship between commercial grades, toxicity, and chemical ingredients of aconite based on the traditional experience, and applied the minimum lethal dose (MLD) assay and UHPLC/Q-TOF-MS analysis to study *** result suggested the grade Ⅰ aconite owned the lowest lethal toxicity (p<0.05, vs grade Ⅱ).Using UHPLC/Q-TOF-MS method coupled with PLS-DA analysis, we discovered eight chemomarkers to distinguish the commodity grades,including hypaconitine, dexyaconitine, dehydrodelcosine, talatizidine, mesaconitine, songorine, talatisamine, and *** their toxicity and pharmacological activity, we found the contents of toxic ingredients hypaconitine, dexyaconitine, and mesaconitine in grade Ⅰ were much lower than that of grade Ⅱ (p<0.01), while the contents of efficacy ingredients songorine, talatisamine, and neoline in grade Ⅰ were the highest (p<0.01, vs grade Ⅱ and grade Ⅲ).Our results first provide scientific evidence for the commodity grades of aconite, and the research method will be of great reference to other foods and herbs.
*** evaluate the efficacy and safety of kushenin (KS) combined with nucleoside analogues (NAs) for chronic hepatitis B (CHB).*** controlled trails (RCTs) of KS combined with NAs for CHB were identified through 7 *** o...
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*** evaluate the efficacy and safety of kushenin (KS) combined with nucleoside analogues (NAs) for chronic hepatitis B (CHB).*** controlled trails (RCTs) of KS combined with NAs for CHB were identified through 7 *** of loss of serum HBeAg, HBeAg seroconversion, undetectable serum HBV-DNA, ALT normalization and adverse events at 48 weeks were abstracted by two *** Cochrane software was performed to assess the risk of bias in the included *** were analyzed with Review Manager 5.3 ***.18 RCTs involving 1684 subjects with CHB were included in the *** combined with NAs including lamivudine (LAM), entecavir (ETV), adefovir dipivoxil (ADV), telbivudine (TLV) showed different degree of improvement in CHB *** combined with NAs increased the frequency of loss of serum HBeAg, HBeAg seroconversion, undetectable HBV-DNA levels and ALT normalization compared with single *** also decreased serum ALT and AST level after one-year *** KS combined with TLV did not show a significant difference in CHB *** side-effects of KS combined with NAs were light and low *** combined with NAs improves the efficacy of NAs in CHB.
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