OBJECTIVE: The purpose of the study was to elucidate molecular evidence of Tenacissoside H (TDH) inhibiting esophageal carcinoma infiltration and ***: EC9706 cells were inoculated subcutaneously in right forelimbs of ...
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OBJECTIVE: The purpose of the study was to elucidate molecular evidence of Tenacissoside H (TDH) inhibiting esophageal carcinoma infiltration and ***: EC9706 cells were inoculated subcutaneously in right forelimbs of nude *** in negative model group were treated with saline *** in positive control group were treated with *** in medicinal groups were treated with *** mice took administration for 3 weeks and were observed for another 3 weeks *** mice were killed for isolation of tumor tissue, inhibition ratio of tumor volume and weight *** expression was examined with *** expression in PI3K/Akt-NF-κB signaling pathway was determined through western blotting ***: TDH inhibits tumor growth greatly, relative tumor Volume being (7.46±2.67), showing significantly difference from negative model group (P<0.05).TDH induced tumor tissues *** rate of PCNA expression aslo decreased significantly, showing statistical difference with the negative model group (P<0.05).In western blotting assay, TDH strongly down-regulated EGFR, PI3K, Akt, p-Akt and NF-κB expression, showing statistical differences (P<0.05) from those in negative model ***: TDH inhibited esophageal carcinoma infiltration and proliferation in *** mechanism related to inhibition on PCNA of transplanted tumors in nude mice and regulation on PI3K/Akt-NF-κB transduction cascade.
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