Objective To study the antiarrhythmic effects of Shen Song Yang Xin Jiao Nang,atraditional Chinese medicine,as detected by heart rate variation(HRV) and heart rate turbulence(HRT),in patients with chronic heart failur...
详细信息
Objective To study the antiarrhythmic effects of Shen Song Yang Xin Jiao Nang,atraditional Chinese medicine,as detected by heart rate variation(HRV) and heart rate turbulence(HRT),in patients with chronic heart failure(CHF). Methods Sixty-six CHF patients,with the inclusion criterion of aged>18 years old and let ventricular ejection fraction(LVEF)<0.40,were randomly assigned to the study group(n=32),whic-h were given 4.8g of Shen Song Yang Xin Jiao Nang daily in three divided doses in addition to standard medicine therapy,or the control group(n=34),which were treated only with standard medicine therapy without Shen Song Yang Xin Jiao *** mean time of follow-up was 3 *** and after three months of treatment,continuous ECG monitoring,echocardiography,HRT and HRV were calculated,and clinical end points including all cause mortality,ventricular tachyc-ardia ventricular fibrillation,were recorded. Results After treatment,HR and TO significantly decreased in both groups(P<0.05),and T-S, sNN50 total,pNN50,SDNN,SDNNI,rMSDD,LF,LF/HF significantly increased(P<0.05),while SDANN and HF significantly increased in study group(P<0.05),yet there was no statistically s-ignificant difference in SDANN and HF in control group between before and after treatment(P>0.05). Aftertreatment,there were statistically significant difference in the changes of HR,TO,TS,sNN50 total, pNN50,SDNN,SDNNI,SDANN,LF,HF between two groups(P<0.05),whist the difference in rMSDD and LF/HF between two groups appeared to be insignificant(P>0.05).The occurrence rates of ventricular tachycardia and proxysmal atrial fibrillation in study group were significantly lower than those in control group(P<0.05)。Conclusion Shen Song Yang Xin Jiao Nang can improve the impaired HRT in patients with CHF, which might be one of its anti-arrhythmic mechanisms.
Objective Cardiac synchronization therapy（CRT） can improve mechanical function of right and left ventricles（RV,LV） in patients（pts） with heart failure（HF）.However,up to 30%pts with CRT failed to clinically ***...
详细信息
Objective Cardiac synchronization therapy（CRT） can improve mechanical function of right and left ventricles（RV,LV） in patients（pts） with heart failure（HF）.However,up to 30%pts with CRT failed to clinically *** of CRT remains a major challenge in the device HF *** present study was to investigate whether electrical cardiac contractility modulation（CCM） on top of CRT therapy would provide additional LV mechanical improvement. Methods Five ptsreceiving CRT or CRT-D were enrolled（LVEF:29.8±5.6%,QRS width: 170±22.4ms,NYHA:3±0,and all with beta-blocker）.After the lead system was placed in RV and LV lateral or posterior-lateral vein for CRT,the CRT lead system was connected to an EP stimulator for acutely delivering *** LV pressure catheter was introduced into the LV chamber for pressure *** LV pressure and its dp/dt were offline *** CCM consisting of three electrical pulses（8V,5 msec/pulse,10 msec inter-pulse interval） was delivered during the LV absolutely refractory period with 30 msec between CRT BiV pacing（BiV） and CCM first *** CCM was delivered in eitherLValone orLVand RV *** test was designed as the BiV alone and BiV plus CCM （BiV+CCM） for each cardiac beat. Results A total of 13 BiV+CCM tests were performed in5 *** LV dp/dt was 1896±389 mmHg/sec during BiV and 2072±369 mmHg/sec during BiV+CCM which significantly increased dp/dtby 11±18%（P=0.05）.Of 13 CCM tests,10 BiV+CCM tests were positive with the dp/dW increased by 16±17%over that during BiV only（P=0.007） while 3 tests were negative with the dp/dt decreased by -6±6%compared to BiV only（P=0.115）.There were no significant difference in LV pressure between BiV and BiV+CCM（systolic:129±23 vs.132±23 mmHg,P=0.258;diastolic:14±12 vs. 14±13 mm Hg,P=0.699）. Conclusions The prior studies using the traditional CCM in RV septum moderately improveds LV mechanical *** study demonstrated that CCM,when delivered through the CRT lead system, can
Objective Many patients post pacemaker implantation developed into atrial fibrillation (AF).The factors that can lead a greater risk of AF post implantation from different researches are *** the first domestic researc...
详细信息
Objective Many patients post pacemaker implantation developed into atrial fibrillation (AF).The factors that can lead a greater risk of AF post implantation from different researches are *** the first domestic research in long-term follow-up,we aim to investigate the risk factors of atrial fibrillation(AF)after pacemaker implantation. Methods Retrospectivel reviewed the clinical events and follow-up datas of 99 patients who accepted pacemaker implantation between January,1991 and January,2003 in our *** use univariate logistic regression analysis to evaluate the effects of coronary heart disease,hypertension, mitral regurgitation,LVEDD,LAD,LVEF,types of arrhythmia,pacemaker types,age and follow-up period in atrial fibrillation and then find the leading risk factors from multivariate logistic regression analysis. Results Totally 99 patients enter this research:male 48/99(48.48%),the average age 61.10±12.42y, SSS 49/99(49.49%),coronary heart disease 10/99(10.10%),hypertension 31/99(31.31%),diabetes mellitus 8/99(8.08%),DDD 51/99(51.52%),VVI 48/99(48.48%),average follow-up period is 109.48±*** of atrial fibrillation is 29.3%(29/99).The univariate logistic regression analysis showed that coronary heart disease(P=0.034,OR=4.304,95%CI 1.114-16.624), LVEDD(P=0.021,OR=1.119,95%CI 1.017-1.232),LAD(P=0.016,OR=1.117,95%CI 1.021-1.221), RAD(P=0.043,OR=1.174,95%CI 1.005-1.371),LEVF(P=0.003,OR=0.894,95%CI 0.817-0.996)are related to the occurrence of AF after pacemaker implantation,while the multivariate logistic regression analysis showed that only the LVEF is related to the occurrence of AF after pacemaker implantation(P=0.028,OR=0.895,95%CI 0.810-0.985). Conclusions Compared with other middle-term studies(follow-up l-3y) that suggesting VVI mode tending to AF,our long-term follow-up datas reveal that the impaird LVEF is a predictor for postimplantation AF.
Objective Catheter-based pulmonary vein isolation（PVI） is an established therapy to treat patients with paroxysmal atrial *** high-density mesh mapper（HDMM）,a novel multi-electrode circumferential mapping catheter...
详细信息
Objective Catheter-based pulmonary vein isolation（PVI） is an established therapy to treat patients with paroxysmal atrial *** high-density mesh mapper（HDMM）,a novel multi-electrode circumferential mapping catheter,guides the circumferential atrium isolation without help of 3D electro-anatomic *** compared the difference of the circumferential pulmonary vein anatomy mapping guided between by Carto system（one 3D electro-anatomic mapping system） and by HDMM. Methods From August 2010 to February 2012,forty-four consecutive patients with paroxysmal atrial fibrillation were scheduled for a first procedure of PVI.A circumferential PV ostial anatomy map was set up in Carto system around the HDMM（HDMM,Bard Electrophysiology） firstly,while the operator was blinded to the Carto ***-guided PVI was performed in every patient by irrigated radiofrequency application,which established another circumferential PV（CPV） ostial anatomy *** study compared the difference between the two images,including the point-to-point straight distance,the area,the perimeter and so on. Results All 176 PVs in 44 patients could be mapped by the HDMM and *** 43.2%of the PV ostial anatomies were matched very well between the two different map *** point-to-point straight distance between the HDMM-guided map and Carto-guided map is（6.20±1.44）*** distance in some PV segments between the two images is *** area of circumferential right PV（CRPV） in the two views is 8.41±2.88mm in Carto map,9.37±1.84 mm in HDMM map respectively（P=0.013）. The area of circumferential left PV（CLPV） is（8.12±2.48）mm in Carto,（8.98±2.33） mm in HDMM respectively（P=0.071）.The CRPV perimeter in Carto and HDMM is（11.63±1.95）mm vs （11.87±1.72）mm（P=0.471）,the CLPV（11.29±1.59）mm vs（11.12±1.71）mm（P=0.573）. Conclusion Compared to the Carto-guided CPV anatomy image,the HDMM-guided one still has some discrepancies,which maybe explain a part of reasons why the high-density mesh ablator（
Objective To investigate the effects of absolute refractory period electrical stimulation(ARPES) with different amplitudes on cardiac function in rabbits with chronic heart failure. Methods Twenty-four New Zealand whi...
详细信息
Objective To investigate the effects of absolute refractory period electrical stimulation(ARPES) with different amplitudes on cardiac function in rabbits with chronic heart failure. Methods Twenty-four New Zealand white rabbits were selected for the experimental animals. After thoracotomy the aortic root was ligatured beyond 1.0cm of ascending aorta,decreased to 60%of original perimeter of *** weeks later,eighteen rabbits with LVEF≤40%(as successful models) were randomly divided into control group(n=6),ARPES-L group(n=6) and ARPES-H group(n=6).An electrode was inserted through jugular veins into the apex of the right ventricle under the X-ray,the control group didn't give any ***-L and ARPES-H group were given RS delayed 30ms stimulation with pulse width *** stimulant voltage was 2 times of diastolic threshold in ARPES-L group and 5 times in ARPES-H *** stimulations continued for 12 *** left ventricular end-systolic dimension(LVESD),left ventricular end-diastolic dimension(LVEDD),left ventricular ejection fraction(LVEF) were measured by ultrasound *** plasma level of brain natriuretic peptide(BNP) was tested by ABC-ELISA method and the differences of mRNA expression of Junctophilin-2(JPH-2) tested by real-time fluorescence-based reverse transcription polymerase chain *** GAPDH as an internal reference gene,get target gene expression relative quantification value(RQ value). Results After ARPES,LVESD and LVEDD(10.34±0.73) mm and(14.30±0.97) mm in ARPES-L group and(10.34±0.96) mm and(14.34±1.18) mm in ARPES-H group were significantly lower than (12.12±1.10) mm and(16.08±1.33) mm in control group(all P<0.05).LVEF in ARPES-L and in ARPES-H group were higher than those in control group(41.38±1.72%and 41.97±1.22%vs. 36.79±2.11%,both P<0.05).LVESD and LVEDD were significantly decreased(P<0.05),LVEF increased(P<0.05) within ARPES-L and ARPES-H group after *** plasma levels of BNP post ARPES were significantly lower in
暂无评论