AIM: To determine whether TFFl is associated with mucosa healing and carcinoma suppression, we assessthe expression of trefoil factor 1 in normal and pathologic gastric mucosa..Methods: Trefoil factor 1 in normal and ...
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AIM: To determine whether TFFl is associated with mucosa healing and carcinoma suppression, we assessthe expression of trefoil factor 1 in normal and pathologic gastric mucosa..Methods: Trefoil factor 1 in normal and pathologic gastric mucosa was assessed by immunohistochemicalmethod, and the average positive OD was estimated by Motic Images Advanced 3.0 ***: Increased TFFl was detected in gastritis, gastric ulcer and duodenal ulcer compared with normalmucosa. The same result could be seen in multiple and compound ulcer compared with simple ulcer. Therewas no significant difference between gastric ulcer and duodenal ulcer, gastritis and simple ulcerrespectively. Increased TFFl was detected in the peripheral mucosa of the gastric adenocarcinomacompared with normal mucosa. The expression of TFFl in gastric adenocarcinoma was related to thedifferentiation of adenocarcinoma. The lower adenocarcinoma differentiated, the weaker TFFl *** was no TFFl expressed in low differentiated adenocarcinoma. The expression of TFFl in middle andhigh differentiated adenocarcinoma was a little lower than that in normal mucosa. But there was nosignificant difference. No TFFl was assessed in esophageal squamous carcinoma and peripheral *** was no significant difference between male and ***: The expression of TFFl was higher in gastritis and peptic ulcer than that in normal mucosa,and was also higher in multiple and compound ulcer than that in simple ulcer. It seems that TFFl plays arole in gastric mucosa protection and epithelial restitution. Increased expression of TFFl in peripheraltissue suggests TFFl is associated with mechanism of carcinoma suppression and *** expression of TFFl in carcinoma and its relativity to the differentiation suggests TFFl is relatedto gland and cell destruction of carcinoma.
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