Epigenetic silencing of the tumor suppressor gene,RARβ through histone deacetylation has been established as an important process of cervical *** pivotal role has led to the suggestion that a combination of retinoids...
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Epigenetic silencing of the tumor suppressor gene,RARβ through histone deacetylation has been established as an important process of cervical *** pivotal role has led to the suggestion that a combination of retinoids selective for RARβ2 with histone deacetylase（HDAC） inhibitors may have therapeutic potential. Valproic acid（VPA）,a HDAC inhibitor,has a critical role in the regulation of gene expression through
1994年中国医学科学院医学信息研究所推出了国内医学信息检索领域第一张的数据库光盘——中国生物医学文献数据库(Chinese Biological Medicine on disc,CBM)这十年以来,中国数字化科技信息资源建设和计算机技术飞速发展,国外先进的数...
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1994年中国医学科学院医学信息研究所推出了国内医学信息检索领域第一张的数据库光盘——中国生物医学文献数据库(Chinese Biological Medicine on disc,CBM)这十年以来,中国数字化科技信息资源建设和计算机技术飞速发展,国外先进的数据库不断引进,国内医学领域数据库建设也蒸蒸日上。目前清华同方、重庆维普、万方数据分别推出了专门面向医学领域的信息资源系统,在传统的文摘型数据库方面,除CBM数据库之外,解放军医学图书馆也推出了CMCC系统,可以说竞争和发展异常活跃。
Background:Our previous studies showed a down-regulation of GRIM-19 inprimary human cervical cancers,and restoration of GRIM-19 induced tumor *** induction of tumor suppressor protein p53 ubiquitination and degradatio...
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Background:Our previous studies showed a down-regulation of GRIM-19 inprimary human cervical cancers,and restoration of GRIM-19 induced tumor *** induction of tumor suppressor protein p53 ubiquitination and degradation by E6 oncoportein of high risk-HPV through forming a stable complex with E6AP is considered as a critical mechanism for cervical tumor *** aims of this study were to determine
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