Background and Aims:Hepatitis B virus immune escape gives a challenge to prevention,diagnoses and treatment to hepatitis *** aim of this study was to explore characteristics and its molecular mechanism of HBV immune e...
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Background and Aims:Hepatitis B virus immune escape gives a challenge to prevention,diagnoses and treatment to hepatitis *** aim of this study was to explore characteristics and its molecular mechanism of HBV immune escape in HBVendemic ***:HBV isolates from 210 patients with coexistence of HBsAg/HBsAb were sequenced for HBsAg major hydrophilic region(MHR) *** vitro biological functional analysis including antigenicity and secretion ability was conducted to study influence of N-glycosylation mutations on viral fitness after identification of N-glycosylation ***:Forty-three percent(89 out of 210) of patients was infected with HBV immune escape mutants among whom 47%(42 out of 89) were found with additional N-glycosylation mutations(Asn-X-Ser/Thr).8 N-glycosylation mutation sites identified in our study were mostly located in the first loop of the "a" determinant.N-glycosylation formation was confirmed at the most frequent sites 129 and 131 together with inserted *** with wild type HBsAg,recombinant HBsAg variants expressed by plasmids in transfected Huh7 cells reacted weakly with anti-HBs using chemiluminescent microparticle enzyme *** gel analysis of secreted virion in supernatant of transfected Huh7 cells indicated that virion enveloping and secretion of these mutants was higher than that of wild type ***:N-glycosylation mutations within HBsAg MHR contribute mostly to immune escape mutants through enhancing viral fitness in HBV endemic area.
Aims:As a member of fibrinogen-related protein superfamily,Fibrinogen-like protein 2(also called fgl2 prothrombinase) has serine protease activity and directly catalyzes prothrombinase into activated thrombinase,which...
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Aims:As a member of fibrinogen-related protein superfamily,Fibrinogen-like protein 2(also called fgl2 prothrombinase) has serine protease activity and directly catalyzes prothrombinase into activated thrombinase,which is considered as an important link on tumor growth and metastasis of
Background/aims: By observing long-term clinical outcome of chronic hepatitis B(CHB) patients after withdrawal of antiviral therapy,we aimed to explore the theraputic strategies of CHB patients after achieving ideal/ ...
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Background/aims: By observing long-term clinical outcome of chronic hepatitis B(CHB) patients after withdrawal of antiviral therapy,we aimed to explore the theraputic strategies of CHB patients after achieving ideal/ satisfactory end-point by nucleoside analogues(NUCs) or IFN-α/peg-IFN-α.
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