作者：
Xue-yuan LiLian-qun ZhangXue-guang ZhangXin LiYu-bo RenXiang-yu MaXin-gang LiDepartment of Neurosurgery
Qilu Hospital of Shandong University Jinan City Shandong Province PR China Department of Neurosurgery Liaocheng People''s Hospital and Liaocheng Clinical School of Taishan Medical University Liaocheng City PR China Department of Pathology Liaocheng People''s Hospital and Liaocheng Clinical School of Taishan Medical University Liaocheng City PR China.252000
Backgroud:Fungal thoracic vertebral osteomyelitis is rare,particularly with epidural abscess causing spinal *** recent literatures show an increasing trend in the number of cases being reported.
Backgroud:Fungal thoracic vertebral osteomyelitis is rare,particularly with epidural abscess causing spinal *** recent literatures show an increasing trend in the number of cases being reported.
Objective To develop effective implants for delivery of 3,4-dihydro-3-methyl-4- oxoimidazo[5,1- d]-as-tetrazine-8-carboxamide(temozolomide;TM) with low initial burst and less *** TM-loaded poly-propylene carbonate(PPC...
Objective To develop effective implants for delivery of 3,4-dihydro-3-methyl-4- oxoimidazo[5,1- d]-as-tetrazine-8-carboxamide(temozolomide;TM) with low initial burst and less *** TM-loaded poly-propylene carbonate(PPC) fiber was fabricated by *** of the fiber sheets were then covered with alginate(ALG).Influences of several preparation parameters on drug delivery behavior were *** micro-morphology of these fibers was studied using scanning electron microscopy and differential scanning *** vitro release properties of two forms of samples were observed and their cytotoxicity against C6 glioma cells was assessed. Results Using strict preparation parameters,smooth and uniform fiber could be obtained only when the PPC concentration was 8%by weight,at 20 cm and a voltage of 15kV between the nozzle and the collection *** diameter was about 3μm. The initial burst of drug-fiber sheets was reduced after the fiber sheets were covered with *** test results suggested that both forms of drug fibers inhibited the C6 glioma cells continuously;and the pure drug-fiber sheets were strongly *** Electrospinning is a reliable fabrication method for M-loaded PPC fibers,and an ALG coating reduces the initial burst of the fiber sheets.
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