Objective To research the association of FOXL2 gene polymorphism and high FOXL2 mRNA levels with polycystic ovary syndrome (PCOS) *** Eighty 23-to 38-year-old nulliparous women with PCOS or without the disease (contro...
Objective To research the association of FOXL2 gene polymorphism and high FOXL2 mRNA levels with polycystic ovary syndrome (PCOS) *** Eighty 23-to 38-year-old nulliparous women with PCOS or without the disease (controls) were recruited at Shengjing Hospital of China Medical *** and qRT-PCR were employed to detect the polymorphism of FOXL2 gene and its *** Three heterozygous mutations/variations were found in 80 patients, including c.168G ＞ A, c.187G ＞ A and c.2804T＞ *** same nucleotide change was not found in the normal *** frequency of this three FOXL2 variations was estimated at 11.3％ , 2.5％ and 13.8％ in PCOS patients, *** mRNA levels of FOXL2in PCOS group was significantly higher than those in control *** Polymorphism and mRNA expression are of prognostic importance in granulosa cell tumors and probably is a pathogenic gene of PCOS.
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