The molecular mechanism of adipocytes lipotoxicity on osteoblasts is still far from completely *** present study was designed to investigate the signaling pathway responsible for adipocytes lipotoxicity on *** conclus...
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The molecular mechanism of adipocytes lipotoxicity on osteoblasts is still far from completely *** present study was designed to investigate the signaling pathway responsible for adipocytes lipotoxicity on *** conclusion,FFAs-ROS-ERK/P38 pathway plays a key role in adipocyte lipotoxicity on osteoblasts in *** evidence provides new insights into the mechanisms
Objective Rheumatoid arthritis(RA) is a chronic inflammatory disease characterized by intraarticular decreases in pH,synovial hyperplasia,and destruction of bone and *** decreased pH (acidosis) is known to promote bon...
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Objective Rheumatoid arthritis(RA) is a chronic inflammatory disease characterized by intraarticular decreases in pH,synovial hyperplasia,and destruction of bone and *** decreased pH (acidosis) is known to promote bone loss by inducing osteoclast ***,the acid-sensing ion channels(ASICs) involved remain largely *** we examine ASICs involved in acid-induced
Objective Previous quantitative studies on bone perfusion by using dynamic contrast enhancement (DCE) MRI have shown a reduced bone marrow perfusion in osteoporotic ***,most frequently used pharmacokinetic models basi...
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Objective Previous quantitative studies on bone perfusion by using dynamic contrast enhancement (DCE) MRI have shown a reduced bone marrow perfusion in osteoporotic ***,most frequently used pharmacokinetic models basically involved the arterial input function(AIF),which was an unstable factor in *** purpose of this study is to characterize bone marrow perfusion properties with a newly established muscle-based model without using AIF.
Summary Although obesity and osteoporosis are two important public health problems that greatly impact mortality and morbidity,the effect of fat mass(FM) on bone mineral density(BMD) remains *** study demonstrated tha...
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Summary Although obesity and osteoporosis are two important public health problems that greatly impact mortality and morbidity,the effect of fat mass(FM) on bone mineral density(BMD) remains *** study demonstrated that increased central body fat had an inversely association with total and leg BMD in female but not *** FM and percent body fat(%BF) was positively associated
Introduction Cancer patients experience many sequelae during and after *** many patients now surviving decades after treatment has ceased,it has been important concerns about late-stage sequelae and their effects on o...
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Introduction Cancer patients experience many sequelae during and after *** many patients now surviving decades after treatment has ceased,it has been important concerns about late-stage sequelae and their effects on overall health and quality of life,including bone *** complications from radiation therapy have been described for breast,brain,pelvic,and blood ***,the etiology of nonmaligancy bone complications in cancer patients treated with radiotherapy remains unclear
Background Whether cigarette smoking can increase the risk of hip fracture in women is unclear. This meta-analysis,which pooled results from 10 prospective cohort studies,was performed to derive a more precise estimat...
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Background Whether cigarette smoking can increase the risk of hip fracture in women is unclear. This meta-analysis,which pooled results from 10 prospective cohort studies,was performed to derive a more precise estimation between cigarette smoking and risk of hip fracture in women. Methods Pubmed,Cochrane Central Register of Controlled Trials and ISI Web of Science were
Background and aims Age at menarche and menopause are associated with cardiovascular disease,diabetes and osteoporosis in Caucasian women,but associations remain unexplored in Chinese ***,we conducted this study to as...
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Background and aims Age at menarche and menopause are associated with cardiovascular disease,diabetes and osteoporosis in Caucasian women,but associations remain unexplored in Chinese ***,we conducted this study to assess associations between age at menarche and menopause with cardiovascular disease,diabetes and osteoporosis in Chinese *** aim of our cross-sectional
作者:
Ye LiXiao-Yu XuCollege of Pharmaceutical Sciences
Institute of Chinese MedicinePharmacology of Chinese materia medica-the key constructing discipline by the State Administrative Bureau of TCMSouthwest University
AIM:To explore the therapeutic effects of Morinda Officinalis Capsule on osteoporosis in ovariectomized rats. METHODS 6-month-old female Sprague-Dawley rats were induced for Postmenopausal osteoporosis (PMOP) by bil...
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AIM:To explore the therapeutic effects of Morinda Officinalis Capsule on osteoporosis in ovariectomized rats. METHODS 6-month-old female Sprague-Dawley rats were induced for Postmenopausal osteoporosis (PMOP) by bilateral ovariectomy and divided into seven groups as follows:sham-operated group, ovariectomized(OVX) control group,OVX treated with xianlinggubao(XLGB)(270 mg·kg·d),OVX
Objective More recently,the relationship between osteoporosis and obesity,especially for central obesity,has become a new research ***,the conclusions remain *** et al reported that increased central body fat was nega...
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Objective More recently,the relationship between osteoporosis and obesity,especially for central obesity,has become a new research ***,the conclusions remain *** et al reported that increased central body fat was negatively associated with BMD in Chinese *** contrast,another study in Taiwan came to an opposite *** circumference(WC) is regarded as the most reliable surrogate of central obesity[7].Increased WC has been demonstrated to be associated
Objective Fracture healing is a complex process that involves both anabolic and catabolic responses. At the onset of fracture repair there is an initial inflammatory phase followed by the differentiation of mesenchyma...
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Objective Fracture healing is a complex process that involves both anabolic and catabolic responses. At the onset of fracture repair there is an initial inflammatory phase followed by the differentiation of mesenchymal stem cells(MSCs) to form a soft cartilage callus and a hard callus of woven bone,which is ultimately remodeled to generate the original cortical *** repair processes recapitulate
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