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BMPRIA-mediated signaling pathway in osteocytes and osteoblasts control bone mineralization

BMPRIA-mediated signaling pathway in osteocytes and osteobla...

引用

中华医学会第七次全国骨质疏松和骨矿盐疾病学术会议

作者： Zhaowen Zong Sixu Chen Min Jia Yue Shen Jianquan Feng Department of Trauma Surgery Daping HospitalThird Military Medical University Department of Biomedical Science Baylor College of DentistryTx A&M Health Science Center

Backgrounds and Objective Bone morphogenetic protein（BMPRIA）-mediated signaling pathway has been shown play an important role in controlling bone hemostasis in *** the present study,we aimed to observe BMPRIA-mediated signaling pathway in osteocytes and osteoblasts play an role in controlling bone mineralization. Methods BMPRIA were conditional knockout in osteocytes and osteoblasts with DMP1-Cre and 3.2 kb Col 1-Cre ERas the promoter respectively,and then X-ray,microCT,Real-time PCR,Goldner

关键词： BMPRIA-mediated signaling pathway in osteocytes and osteoblasts control bone mineralization

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Effect of Whole Body Vibration Therapy on Circulating Serotonin Levels in an Ovariectomized Rat Model of Osteoporosis

Effect of Whole Body Vibration Therapy on Circulating Seroto...

引用

中华医学会第七次全国骨质疏松和骨矿盐疾病学术会议

作者： Qiu-Shi Wei Li Huang Xian-Hong Chen Hai-Bin Wang Wei-Shan Sun Shao-Chuan Huo Zi-Qi Li Wei-Min Deng Department of Rehabilitation General Hospital of Guangzhou Military Command of PLA Key Laboratory of Orthopaedics & Traumatology Guangzhou University of Traditional Chinese Medicine

Objectives Studies have reported that whole body vibration(WBV) played a vital role in bone *** serotonin has been demonstrated to be involved in negative regulating bone mass in rodents and ***,both WBV and inhibition of serotonin biosynthesis could suppress RANKL-induced osteoclastogenesis in *** study is to investigate the effect of WBV therapy on the expression of serum serotonin in ovariectomized rats.

关键词： OVX RANKL Effect of Whole Body Vibration Therapy on Circulating Serotonin Levels in an Ovariectomized Rat Model of Osteoporosis Model

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PTH promotes mesenchymal stem cell differentiation and inhibits cell senescence:an alternation in skeletal engineering and regeneration

PTH promotes mesenchymal stem cell differentiation and inhib...

引用

中华医学会第七次全国骨质疏松和骨矿盐疾病学术会议

作者： Qun Cheng Chao Xie Edward Schwarz Fudan University affiliated Huadong Hospital Shanghai Geriatric InstituteDepartment of OsteoporosisResearch Section of Geriatric Metabolic bone disease Center for Musculoskeletal Research University of Rochester

Objective Bone and cartilage defect,most commonly caused by aging and degenerative disease, has become the primary target of tissue engineering due to a lack of effective treatments and limited regenerative *** limited source of autograft necessitates the development of alternative cell *** stem cells with multiple lineage differentiation potentials from various sources can

关键词： PTH promotes mesenchymal stem cell differentiation and inhibits cell senescence:an alternation in skeletal engineering and regen

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Progressive diaphyseal dysplasia:case report

Progressive diaphyseal dysplasia:case report

引用

中华医学会第七次全国骨质疏松和骨矿盐疾病学术会议

作者： Hui Zheng Chong Shao Jin-wei He Wen-zhen Fu Zhen-lin Zhang Metabolic Bone Disease and Genetic Research Unit Department of Osteoporosis and Bone DiseasesShanghai Jiao Tong University Affliated the Sixth Peoples Hospital

Objective Progressive diaphyseal dysplasia(PDD) or Camurati-Engelmann disease is a rare autosomal dominant progressive diaphyseal dysplasia caused by mutations in the transforming growth factor-β1(TGFβ1) *** objective of this study was to characterize the clinical manifestations and features of PDD and identify the mutation of the causative gene in a Chinese family with PDD. Method We investigated a non-consanguineous Chinese family in which an 18-year-old male,his mother and grandmother were affected with ***,203 persons,including the proband,his

关键词： PDD Progressive diaphyseal dysplasia:case report

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Relation of Age,Gender,and Bone Mineral Density to Circulating 25 hydroxyvitamin D Levels in Chinese Adults

Relation of Age,Gender,and Bone Mineral Density to Circulati...

引用

中华医学会第七次全国骨质疏松和骨矿盐疾病学术会议

作者： Qiu-Shi Wei Wei-Min Deng Xin Tan Wei-Yi Huang Li Huang Wei-Shan Sun Department of Rehabilitation General Hospital of Guangzhou Military Command of PLA

Background Vitamin D insufficiency is high prevalence and has been linked to low bone mineral density(BMD),but this relationship is ignored in *** study is to investigate the relation of circulating 25(OH)D levels to age,gender,and BMD in adults living in Guangzhou. Methods This cross-sectional study comprised 188 women and 122 men aged 17-88 years who

关键词： BMD Relation of Age,Gender,and Bone Mineral Density to Circulating 25 hydroxyvitamin D Levels in Chinese Adults

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Finite element analysis of trabecular bone with bone marrow fat

Finite element analysis of trabecular bone with bone marrow ...

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中华医学会第七次全国骨质疏松和骨矿盐疾病学术会议

作者： Jun Zhu Heather T Ma James F Griffith Xinxin Zhao Rong Ren Department of Electronic & Information Engineering Harbin Institute of Technology Shenzhen Graduate School Department of Diagnostic Radiology and Organ Imaging The Chinese University of Hong Kong

Objective Recent studies had shown that osteoporotic bone had significantly increased marrow fat compare to the subjects with normal bone mineral density(BMD).However,there was no study to further investigate the mechanical function of the marrow fat in the osteoporotic *** order to figure out the mechanical contribution of marrow fat in bone strength,this study simulated cancellous bone in two extremely conditions:one consisted of trabecular bone only and the other consisted of trabecular bone and

关键词： Finite element analysis of trabecular bone with bone marrow fat simulation BMD

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Correlation of Bone mineral density and canal flare index of the proximal femur in the patients undergoing total hip arthroplasty

Correlation of Bone mineral density and canal flare index of...

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中华医学会第七次全国骨质疏松和骨矿盐疾病学术会议

作者： Yi-zhong Li Hua-feng Zhuang Si-qing Cai Jin-Kuang Lin Xue-Dong Yao Hai-Ming Yu Yuan-Cheng Pan The Second Hospital of Fujian Medical University

Objective The osteoporosis is common in the patients undergoing total hip arthroplasty and also is a common factor leading to early failure of *** thinning cortex and large marrow cavity of proximal femur were present in the aged and the osteoporotic *** canal flare index(CFI) is a good index to evaluate the proximal femur *** measurement of bone mineral density(BMD) over proximal femur with dual-energy x-ray absorptiometry(DXA) is

关键词： BMD Correlation of Bone mineral density and canal flare index of the proximal femur in the patients undergoing total hip arthroplasty

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Progressive Pseudorheumatoid Dysplasia is Characterized by Diffuse Osteopenia and Severe Impairment of Articular Cartilage Biomechanical Properties in Han Chinese Population

Progressive Pseudorheumatoid Dysplasia is Characterized by D...

引用

中华医学会第七次全国骨质疏松和骨矿盐疾病学术会议

作者： Ru-Chun Dai Ya-Lin Zeng Shi-Di Hu Ling-Qing Yuan Xian-Ping Wu Ye-Bin Jiang Er-Yuan Liao Institute of Endocrinology and Metabolism the Second Xiangya Hospital of Central South University Department of Radiology University of Michigan Hospitals

Objective Progessive pseudorheumatoid dysplasia(PPD) is characterized by continuous degeneration and loss of articular *** present study was designed to investigate bone mineral density(BMD), bone turnover biomarkers in two PPD patients,and bone histomorphometry,cartilage biomechanics,and ultrastructural changes before as well as after biomechanical tests in one female PPD patient.

关键词： PPD Progressive Pseudorheumatoid Dysplasia is Characterized by Diffuse Osteopenia and Severe Impairment of Articular Cartilage Biomechanical Properties in Han Chinese Population BMD

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A randomized,multicenter controlled trial to compare the efficacy of recombinant human parathyroid hormone(1-34) with elcatonin in postmenopausal women with osteoporosis in China

A randomized,multicenter controlled trial to compare the eff...

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中华医学会第七次全国骨质疏松和骨矿盐疾病学术会议

作者： Xiuzhen Zhang Miao Xuan Jun Yang Bo Wang Tongji Hospital of Tongji University Department of Endocrinology

Background Recombinant human parathyroid hormone(1-34)(rhPTH(1-34)) given by injection is a new seventh class drug of biological products,which is prepared by adopting gene recombination ***(1-34) is mainly used to treat osteoporosis,especially for postmenopausal *** study compared the clinical efficacy and safety of rhPTH(1-34) with elcatonin for treating postmenopausal women with osteoporosis in 11 urban areas of China.

关键词： with elcatonin in postmenopausal women with osteoporosis in China A randomized,multicenter controlled trial to compare the efficacy of recombinant human parathyroid hormone BMD

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Estrogen-mimicking isoflavone Genistein prevents the bone loss due to hypoxia in a rat model of Obstructive Sleep Apnea-Hypopnea Syndrome

Estrogen-mimicking isoflavone Genistein prevents the bone lo...

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中华医学会第七次全国骨质疏松和骨矿盐疾病学术会议

作者： Lige Song Xiao Liang Yun Zhou Department of Endocrinology Tongji HospitalTongji University School of Medicine School of Basic Medical Sciences Fudan University

The incidences of Obstructive Sleep Apnea-Hypopnea Syndrome(OSAHS) have been on rise in general population,in part,due to increasing *** incidences are 2-fold higher in postmenopausal women,further exacerbating their risk of osteoporosis and *** and other systemic complications of OSAHS including oxidative stress and metabolic abnormalities have been shown to cause detrimental effect on osteoblast proliferation and differentiation and also increase osteocalsts activity.

关键词： OVX Genistein OSAHS Estrogen-mimicking isoflavone Genistein prevents the bone loss due to hypoxia in a rat model of Obstructive Sleep Apnea-Hypopnea Syndrome

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