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A comparative study for the effects of three common arthritis medicines(celecoxib,methotrexate and dexamethasone) on bone quality in healthy SD rats

A comparative study for the effects of three common arthriti...

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中华医学会第七次全国骨质疏松和骨矿盐疾病学术会议

作者： Yanzhi Liu Yan Chen Xiang Gao Yanjie Su Liao Cui Guangdong key Laboratory for Research and Development of Natural Drugs

AIM To determine the long-term effects of celecoxib(Cel),methotrexate(MTX) and dexamethasone (Dex),which are the common rheumatoid arthritis(RA) medicines,on skeleton in healthy SD rats by performingμCT,bone biomechanical,bone mineral density,bone histomorphometry and serum indicator analyses. Methods Thirty-two female healthy SD rats aged 12 weeks were divided into 4 groups randomly: 1).Healthy Control group(CON,saline,oral gavage);2).Dexamethasone group(Dex,Tianjin Tianyao

关键词： MTX A comparative study for the effects of three common arthritis medicines celecoxib,methotrexate and dexamethasone on bone quality in healthy SD rats

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Lower Serum Nuclear receptor coactivator-3 Levels in Postmenopausal Women with Osteoporosis and Osteopenia are related to Lumbar Spine Bone Mineral Density

Lower Serum Nuclear receptor coactivator-3 Levels in Postmen...

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中华医学会第七次全国骨质疏松和骨矿盐疾病学术会议

作者： Qiushi Wei Haibin Wang Xianhong Chen Xin Tan Weishan Sun Weimin Deng Department of Rehabilitation General Hospital of Guangzhou Military Command of PLA Key Laboratory of Orthopaedics & Traumatology Guangzhou University of Traditional Chinese Medicine

Objective Nuclear receptor coactivator3(NCOA3) is a member of the steroid receptor coactivator family that modulates estrogen receptor alpha(ERα) activity to promote proliferation and differentiation in human *** association was found between NCOA3 alleles and lumbar spine bone mineral density(LSBMD) in Caucasian men,but the relation between NCOA3 and bone metabolism in postmenopausal women(PMW) remains *** study is to investigate the levels of serum

关键词： BMD PMW Lower Serum Nuclear receptor coactivator-3 Levels in Postmenopausal Women with Osteoporosis and Osteopenia are related to Lumbar Spine Bone Mineral Density

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Effects of Bushenhuogu Decoction on Bone Mineral Density(BMD),Biomechanics,25-(OH)D3,and 1,25-(OH)2D3 of Ovariectomized Osteoporosis Rats

Effects of Bushenhuogu Decoction on Bone Mineral Density(BMD...

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中华医学会第七次全国骨质疏松和骨矿盐疾病学术会议

作者： Bo Shuai Lin Shen Union Hospital Tongji Medical ColleageHuazhong University of Science and Technology

Objective To investigate the curative effects of Bushenhuogu decoction on the level of 25-hydroxy vitamin D(25-(OH)D3) and 1,25-dihydroxyvitamin D3(1,25-(OH)2D3 ) in blood-serum,liver and kidney in ovariectomized osteoporosis rats,and to conform the effective methods for treating osteoporosis with the TCM drugs. Methods A completely randomized controlled study was *** hundred and eight female

关键词： BMD Biomechanics,25 Effects of Bushenhuogu Decoction on Bone Mineral Density OH)2D3 of Ovariectomized Osteoporosis Rats OH)D3,and 1,25

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Inhibitory Effect of Adenovirus-Mediated siRNA-Targeting BMPR-IB on UHMWPE-Induced Bone Destruction in the Murine Air Pouch Model

Inhibitory Effect of Adenovirus-Mediated siRNA-Targeting BMP...

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中华医学会第七次全国骨质疏松和骨矿盐疾病学术会议

作者： Yang Wang Ning-Ning Wu Min Hu Yu-Qin Mou Rui-Dong Li Bai-Cheng He Liang Chen Zhong-Liang Deng Department of Orthopaedics Second Affiliated Hospital of Chongqing Medical University Ministry of Education Key Laboratory Department of Clinical Laboratory Testing DiagnosticsChongqing Medical University College of Pharmacy Chongqing Medical University

Objective Adenovirus expressing small interfering RNA(siRNA)-targeting BMPR-IB was locally administered into the air pouch of mice to improve bone resorption induced by ultrahigh molecular weight polyethylene(UHMWPE) particles. Method Air pouches were established on the back of BALB/c mice,followed by the surgical introduction of a section of calvaria from a syngeneic mouse *** bone-implanted pouches were stimulated with the UHMWPE ***-containing mice were divided into three study

关键词： UHMWPE siRNA Inhibitory Effect of Adenovirus-Mediated siRNA-Targeting BMPR-IB on UHMWPE-Induced Bone Destruction in the Murine Air Pouch Model Model

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The association between polymorphisms in SOST gene and bone response to alendronate treatment in postmenopausal Chinese women with osteoporosis or osteopenia

The association between polymorphisms in SOST gene and bone ...

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中华医学会第七次全国骨质疏松和骨矿盐疾病学术会议

作者： Peiran Zhou Mei Li Eryuan Liao Zhenlin Zhang Decai Chen Jian Liu Wen Wu Xiaoping Xing Weibo Xia Ling Xu Department of Endocrinology Key Laboratory of Endocrinology of Ministry of HealthPeking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical Science Institute of Endocrinology and Metabolism Second Xiangya Hospital of Central South University Metabolic Bone Disease and Genetics Research Unit Department of Osteoporosis and Bone DiseasesShanghai Sixth Peoples Hospital Affiliated with Shanghai Jiao Tong University Department of Endocrinology Osteoporosis Education CenterWest China HospitalSichuan University Department of Orthopedics Xijing Hospitalthe Fourth Liberation Army University Department of Endocrinology Guangdong General Hospital Department of Endocrinology Key Laboratory of Endocrinology of Ministry of HealthPeking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical ScienceBeijingChina Department of Obstetrics and Gynecology Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical Science

Objective Sclerostin is an antagonist to Wnt signaling *** aim was to investigate the association between polymorphisms in SOST gene and bone response to alendronate treatment in Chinese postmenopausal women with osteoporosis or osteopenia. Methods In this prospective,multicenter study,545 postmenopausal women(62.1±7.1 years old) with osteopenia or osteoporosis were randomized into:low-dose(70mg/2w) and standard-dose(70mg/w)

关键词： BMD The association between polymorphisms in SOST gene and bone response to alendronate treatment in postmenopausal Chinese women with osteoporosis or osteopenia

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骨质疏松健康教育

骨质疏松健康教育

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第9届中国健康服务业大会暨中华医学会第七次全国健康管理学学术会议

作者：李小雪解放军总医院健康管理研究院国宾二科

骨质疏松已经严重影响人们的健康水平，但是人们对骨质疏松的认识是随着历史的发展和技术的进步逐渐深化的，大多数认为全身骨质减少即为骨质疏松，直到1990年在丹麦举行的第三届国际骨质疏松研讨会上，以及1993年在香港举行的第四届国... 详细信息

骨质疏松已经严重影响人们的健康水平，但是人们对骨质疏松的认识是随着历史的发展和技术的进步逐渐深化的，大多数认为全身骨质减少即为骨质疏松，直到1990年在丹麦举行的第三届国际骨质疏松研讨会上，以及1993年在香港举行的第四届国际骨质疏松研讨会上，骨质疏松才有一个明确的定义，并得到世界的公认：原发性骨质疏松是以骨量减少、骨的微观结构退化为特征的，致使骨的脆性增加以及易于发生骨折的一种全身性骨胳疾病。每年的10月20日定为"国际骨质疏松日"目前尚未有效安全的骨质疏松治疗措施，而有效的健康教育是骨质疏松防治的最经济有效的手段。为了促进骨质疏松健康教育有效开展，针对骨质疏松健康教育的意义、现状、内容、方法，强调骨质疏松健康教育的重要性，通过有效的骨质疏松健康教育，使人们采取健康的行为方式，提高生命质量。

关键词：骨质疏松健康教育内容方法

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Hepcidinl knockout mice display defects in bone microarchitecture and changes of bone formation markers

Hepcidinl knockout mice display defects in bone microarchite...

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中华医学会第七次全国骨质疏松和骨矿盐疾病学术会议

作者： Guangsi Shen Xi Huang Guoyang Zhao Lulin Liu Youjia Xu Department of Orthopaedics The Second Affiliated Hospital of Soochow University Division of Rheumatology Department of MedicineNew York University(NYU)School of MedicineNYU Hospital for Joint Diseases

Introduction It was reported that iron overload is a risk factor of ***,in these studies,animals vary from mice to rat and pig,and were experimentally iron *** results of reports vary with the doseand forms of iron and animal *** get a better understanding of the effect of iron overload on bone and eliminate the influence of the dose and forms of iron,the hepcidinl(Hep1) knockout mice were used in this *** bone phenotype and iron status of Hep1 knockout and wildtype

关键词： Hepcidinl knockout mice display defects in bone microarchitecture and changes of bone formation markers

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Impact of Switching to a Tenofovir-based Antiretroviral Regimen on Bone Turnover in Chinese HIV-Infected Individuals

Impact of Switching to a Tenofovir-based Antiretroviral Regi...

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中华医学会第七次全国骨质疏松和骨矿盐疾病学术会议

作者： Evelyn Hsieh Liana Fraenkel Weibo Xia Yang Han Ting Zhu Jing Xie Karl Insogna Qu Cui Lixia Zhang Elizabeth Bradley Taisheng Li Peking Union Medical College Hospital Department of Infectious Diseases Yale School of Medicine Department of Rheumatology Peking Union Medical College Hospital Department of Endocrinology Yale School of Public Health

Background/Purpose Few studies have evaluated the impact of anti-retroviral therapy(ART) on bone in Chinese *** measured bone turnover markers(BTMs) in Chinese HIV+ patients in a cohort of treatment-failure patients initiated on second-line Tenofovir(TDF)-based therapy,compared to patients receiving standard first-line zidovudine(AZT)-based therapy,and hypothesized that levels of

关键词： HIV TDF Impact of Switching to a Tenofovir-based Antiretroviral Regimen on Bone Turnover in Chinese HIV-Infected Individuals AZT

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The Phenotype and Genotype of Fibrodysplasia Ossificans Progressiva in China:A Report of 72 Cases

The Phenotype and Genotype of Fibrodysplasia Ossificans Prog...

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中华医学会第七次全国骨质疏松和骨矿盐疾病学术会议

作者： Keqin Zhang Wei Zhang Lige Song Jing Pang Hongxing Ma Eileen Shore Frederick Kaplan Peijun Wang Department of Endocrinology Tongji Hospital Affiliated with Tongji University Department of Endocrinology The First Affiliated Hospital of Nanjing Medical University Center for Research in FOP and Related Disorders the Perelman School of Medicine at the University of Pennsylvania

Objective Fibrodysplasia ossificans progressiva,an ultra-rare and disabling genetic disorder of skeletal malformations and progressive heterotopic ossification(HO),is the most catastrophic condition of skeletal metamorphosis in *** clinical features of large group Chinese FOP patient are needed. Methods We studied 72 patients with FOP in China and analyzed their phenotypes and genotypes comprising the world' s largest ethnically homogeneous population of FOP patients. Results Ninety-nine percent of patients(71/72 cases) were of Han nationality;one percent of patients

关键词： FOP The Phenotype and Genotype of Fibrodysplasia Ossificans Progressiva in China:A Report of 72 Cases

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The association between polymorphisms in DKK1 gene and bone response to alendronate treatment in postmenopausal Chinese women with osteoporosis or osteopenia

The association between polymorphisms in DKK1 gene and bone ...

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中华医学会第七次全国骨质疏松和骨矿盐疾病学术会议

作者： Peiran Zhou Mei Li Eryuan Liao Zhenlin Zhang Decai Chen Jian Liu Wen Wu Xiaoping Xing Weibo Xia Ling Xu Department of Endocrinology Key Laboratory of Endocrinology of Ministry of HealthPeking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical Science Institute of Endocrinology and Metabolism Second Xiangya Hospital of Central South University Metabolic Bone Disease and Genetics Research Unit Department of Osteoporosis and Bone DiseasesShanghai Sixth Peoples Hospital Affiliated with Shanghai Jiao Tong University Department of Endocrinology Osteoporosis Education CenterWest China HospitalSichuan University Department of Orthopedics Xijing Hospitalthe Fourth Liberation Army University Department of Endocrinology Guangdong General Hospital Department of Obstetrics and Gynecology Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical Science

Objective Dickkopf-1(DKK1) is antagonist to Wnt signaling *** aim was to investigate the association between DKK1 gene polymorphisms and bone response to alendronate treatment in Chinese postmenopausal women with osteoporosis or osteopenia. Methods In this prospective,multicenter study,545 postmenopausal women(62.1±7.1 years old) with osteopenia or osteoporosis were randomized into:low-dose(70mg/2w) and standard-dose(70mg/w) alendronate(ALN) ***1 polymorphisms were detected by TaqMan pre-designed SNP genotyping

关键词： BMD The association between polymorphisms in DKK1 gene and bone response to alendronate treatment in postmenopausal Chinese women with osteoporosis or osteopenia DKK

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