BACKGROUND Bone marrow mesenchymal stem cells(BMSCs) are able to differentiate into different cell lineages such as adipocytes and *** a stable and reliable induction method to induce BMSCs to differentiate into adipo...
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BACKGROUND Bone marrow mesenchymal stem cells(BMSCs) are able to differentiate into different cell lineages such as adipocytes and *** a stable and reliable induction method to induce BMSCs to differentiate into adipocytes is of great help in studying prevention and treatment of osteoporosis and skeletal-related diseases. OBJECTIVE To investigate the optimal conditions for induced differentiation of BMSCs into
Objective Recently,the association of bone loss and liver diseases have become a hot area for *** epidemiological evidences have suggested that,as a complication,osteopenia and osteoporosis,even osteoporotic fractures...
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Objective Recently,the association of bone loss and liver diseases have become a hot area for *** epidemiological evidences have suggested that,as a complication,osteopenia and osteoporosis,even osteoporotic fractures are implicated in hepatic diseases such as cirrhosis,viral hepatitis, autoimmune hepatitis,even after liver ***,most studies were conducted in certain
Osteoporotic vertebral compressed fractures(VCFs) are the most common osteoporotic fractures. Although percutaneous vertebroplasty(PVP) reportedly relieves pain and improves function,a recent pooled analysis from two ...
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Osteoporotic vertebral compressed fractures(VCFs) are the most common osteoporotic fractures. Although percutaneous vertebroplasty(PVP) reportedly relieves pain and improves function,a recent pooled analysis from two multicenter randomized controlled trials concluded the improvement in pain and disability treated with PVP was similar to those with sham *** meta-analysis we therefore
Obejects Iron has recently been recognized as an independent risk factor for osteoporosis. Reportedly,excess iron could promote osteoblast differentiation and bone *** aim to evaluate the effect of iron on osteoblast ...
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Obejects Iron has recently been recognized as an independent risk factor for osteoporosis. Reportedly,excess iron could promote osteoblast differentiation and bone *** aim to evaluate the effect of iron on osteoblast differentiation and bone formation in zebrafish and further investigate potential benefits of deferoxamine(DFO),a powerful iron chelator,in iron-overloaded zebrafish.
Objective Iron overload has recently been connected with bone mineral density in osteoporosis,especially in postmenopausal women,who often experience decreased estrogen and increased iron *** study was to explore whet...
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Objective Iron overload has recently been connected with bone mineral density in osteoporosis,especially in postmenopausal women,who often experience decreased estrogen and increased iron *** study was to explore whether decreased estrogen in ovariectomized rats could affect iron metabolism. Methods Twelve3-month-old female SD rats were divided into 2 groups:OVX group and Sham
Objective Primary osteoporosis is a very common disease in eldely patients,and it caused a great deal of threat to health and life in elderly patients,we intend to explore the association between quality of life and s...
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Objective Primary osteoporosis is a very common disease in eldely patients,and it caused a great deal of threat to health and life in elderly patients,we intend to explore the association between quality of life and social support in the elderly patients with primary osteoporosis. Methods A total of 214 elderly patients screened with bone density examination were divided into two groups,case group(elderly patients with primary osteoporosis,112) and control group(elderly patients
Objective Kyphoplasty is conventionally indicated for osteoporotic vertebral fractures or *** on the surgical principle,the current study was to test the feasibility and therapeutic effect of kyphoplasty for treating ...
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Objective Kyphoplasty is conventionally indicated for osteoporotic vertebral fractures or *** on the surgical principle,the current study was to test the feasibility and therapeutic effect of kyphoplasty for treating severe osteoporotic vertebral fractures which was relative contraindications before. Methods 48 vertebrae of 35 patients(33 females and 2 males with the mean age of 74.2 years.)
The molecular mechanism of adipocytes lipotoxicity on osteoblasts is still far from completely *** present study was designed to investigate the signaling pathway responsible for adipocytes lipotoxicity on *** conclus...
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The molecular mechanism of adipocytes lipotoxicity on osteoblasts is still far from completely *** present study was designed to investigate the signaling pathway responsible for adipocytes lipotoxicity on *** conclusion,FFAs-ROS-ERK/P38 pathway plays a key role in adipocyte lipotoxicity on osteoblasts in *** evidence provides new insights into the mechanisms
Aim Mesechymal stem cells as pluripotent cells are involved in the differentiation of adipocytes under regulation of genes and transcription *** plasticity observed between adipocytes and osteoblasts differentiation i...
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Aim Mesechymal stem cells as pluripotent cells are involved in the differentiation of adipocytes under regulation of genes and transcription *** plasticity observed between adipocytes and osteoblasts differentiation is the basis of trans-differentiation,observed inboth experimental and clinical level. The trans-differentiation of BMMSC primary cell culture was established to gain knowledge about the endocrine effect of bone marrow microenvironment.
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