作者：
C XuW XuK-F XuQ WangY XiongZ GuoX ChenF HuangJ XuY ZhongY ZhuX JuY PengL WangX ZhangR JiangD LiT JiangD XuC JiangD SongD TangZ ZouC ZhangT JoshiL JiaDepartment of Computer Science and Engineering
University of CaliforniaRiversideCAUSA Department of Computer ScienceInformatics Institute and C.S.Bond Life Sciences CenterUniversity of MissouriColumbiaMOUSA United Laboratory of Polar Medical SciencesState Key Laboratory of Medical Molecular BiologyInstitute of Basic Medical SciencesChinese Academy of Medical SciencesBeijingChina Department of Biochemistry and Molecular Biology
State Key Laboratory of Medical Molecular BiologyInstitute of Basic Medical SciencesChinese Academy of Medical SciencesPeking Union Medical CollegeTsinghua UniversityBeijingChina Center for Translational Medicine
Peking Union Medical College HospitalPeking Union Medical CollegeBeijingChina School of Computer ScienceBeijing Institute of TechnologyBeijingChina Luzhou Medical School Affiliated Hospital of Traditional Chinese MedicineSichuanChina United Laboratory of Polar Medical Sciences
State Key Laboratory of Medical Molecular BiologyInstitute of Basic Medical SciencesChinese Academy of Medical SciencesBeijingChina Center for Translational MedicinePeking Union Medical College HospitalPeking Union Medical CollegeBeijingChina Department of Biochemistry and Molecular BiologyState Key Laboratory of Medical Molecular BiologyInstitute of Basic Medical SciencesChinese Academy of Medical SciencesPeking Union Medical CollegeTsinghua UniversityBeijingChina Institute of Basic Medical SciencesChinese Academy of Medical SciencesPeking Union Medical CollegeTsinghua UniversityBeijingChina State Key Laboratory of MycologyInstitute of MicrobiologyChinese Academy of SciencesBeijingChina MOE Key Laboratory of Bioinformatics and Bioinformatics DivisionTNLIST/Department of AutomationTsinghua UniversityBeijingChina Shanghai Institutes for Biological SciencesChinese Academy of SciencesShanghaiChina MOE Key Laboratory of Bioinformatics and Bioinformatics DivisionTNLIST/Department of AutomationTsinghua UniversityBeijingChina
Genome-wide gene expression measurements have enabled comprehensive studies that integrate the changes of gene expression and phenotypic information to uncover their novel *** we reported theassociation analysis betwe...
Genome-wide gene expression measurements have enabled comprehensive studies that integrate the changes of gene expression and phenotypic information to uncover their novel *** we reported theassociation analysis between psychophysical phenotypes and genome-wide gene expression changes in human adaptation to one of the most extreme climates on Earth, the Antarctic Dome *** A is the highest ice feature in Antarctica, and may be the coldest, driest and windiest location on *** is considered unapproachable due to its hostile *** 2007, a Chinese team of 17 male explorers made the expedition to Dome A for scientific ***, 133 psychophysical phenotypes were recorded, and genome-wide gene expression profiles from the blood samples of the explorers were measured before their departure and upon their arrival at Dome *** found that mood disturbances, including tension (anxiety), depression, anger and fatigue, had a strong, positive, linear relationship with the level of a male sex hormone, testosterone, using the Pearson correlation coefficient (PCC) *** also demonstrated that significantly lowest-level Gene Ontology groups in changes of gene expression in blood cells with erythrocyte removal were consistent with the adaptation of the psychophysical ***, we discovered a list of genes that were strongly related to significant phenotypes using phenotype and gene expression PCC ***, among the 70 genes that were identified, most were significantly related to mood disturbances, where 42 genes have been reported in the literature mining, suggesting that the other 28 genes were likely novel genes involved in the mood disturbance *** together, our association analysis provides a reliable method to uncover novel genes and mechanisms related to phenotypes, although further studies are needed.
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