Background Subjects with major depressive disorder(MDD)have a high suicide *** evidence suggests that uric acid(UA)may be involved in the pathophysiology of *** purpose of this study was to evaluate whether serum UA l...
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Background Subjects with major depressive disorder(MDD)have a high suicide *** evidence suggests that uric acid(UA)may be involved in the pathophysiology of *** purpose of this study was to evaluate whether serum UA levels were associated with suicide risk in MDD *** One hundred and four female patients with MDD(52 patients with suicide risk and 52 patients without suicide risk)and 52 healthy individuals were enrolled in the precent *** suicide risk was evaluated by Mini International Neuropsychiatric Interview(M.I.N.I).Fasting serum levels of UA,as well as glucose,lipid and renal function were *** Serum UA levels in MDD patients with suicide risk(245.01.17±55.44 μmol/L)were significantly lower than those without suicide risk(274.17±72.65 μmol/L)(P=0.017)and healthy controls(271.4±55.25 μmol/L)(P=0.030).There was no difference between MDD patients without suicide risk and healthy controls(P=0.821)in serum UA *** logistic regression analysis revealed a significant relationship between suicide risk and decreased serum UA levels(P=0.010)in MDD *** Decreased serum UA levels are associated with suicide risk in MDD *** system dysfunction may be involved in the neurobiological basis of suicide risk in these patients.
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