Background:Altered microRNA profile exists in many infectious diseases such as *** a remarkable immunosuppressive effect,CD39 Tregs cells play an important role in the regulation of immune balance in *** the correlati...
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Background:Altered microRNA profile exists in many infectious diseases such as *** a remarkable immunosuppressive effect,CD39 Tregs cells play an important role in the regulation of immune balance in *** the correlation between microRNA change and the ratio of CD39 Tregs in sepsis patients has yet not been *** this study,the altered microRNAs expression profile in sepsis patients was ***,the correlation between microRNAs and severity of disease and prognosis was ***,the correlation between microRNA and the percentage of peripheral blood CD39 Tregs was also investigated and further verified by animal ***:Sixty sepsis patients and 30 healthy controls were *** difference in microRNA expression was investigated by microRNA microarray and further confirmed by *** correlation between microRNAs changes and SOFA score,severity of sepsis and survival was *** percentage of CD39+Tregs in peripheral blood of sepsis patients was measured by flow *** correlation between microRNAs and percentage of CD39+Tregs was analyzed and further confirmed by mouse sepsis ***:Compared with the healthy controls,the sepsis patients exhibited a significant elevated microRNA-155(miR-155)level(p<0.05),which related positively to higher SOFA score(r=0.641,p<0.05)and more severity of *** area under ROC curve of miR-155 used for prediction of 28 d survival was 0.763 with a cut-off point of *** with miR-155 level>2.47 had a lower 28 d survival(p<0.05).The miR-155 level of patients was proportional to the percentage of CD39+Tregs(r=0.637,p<0.05).After transfected with miR-155 inhibitor,the ratio of CD39+Tregs in mice with sepsis was significantly reduced(p<0.05).Conclusions:A higher level of miR-155 indicated a more severe condition and poor prognosis in sepsis *** possible underlying mechanism could be that miR-155 induced the percentage of CD39+Tregs and thus immunos
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