Syntabulin is a microtubule-associated protein that mediating anterograde transport of syntaxin-1 to neuronal processes. Here we showed that syntabulin was expressed in mouse pancreas and insulin-secretingβ-*** its d...
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Syntabulin is a microtubule-associated protein that mediating anterograde transport of syntaxin-1 to neuronal processes. Here we showed that syntabulin was expressed in mouse pancreas and insulin-secretingβ-*** its distribution in neurons, syntabulin was found to mainly reside in cytoplasm and co-localize with microtubule and insulin-containing granules. Knock-down of syntabulin by shRNA significantly reduced
Objective To perform a systematic meta-analysis of differences in the hypoglycemic effect of acarbose in patients with diabetes mellitus(DM) consuming an Eastern or Western diet. Methods Records were retrieved from th...
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Objective To perform a systematic meta-analysis of differences in the hypoglycemic effect of acarbose in patients with diabetes mellitus(DM) consuming an Eastern or Western diet. Methods Records were retrieved from the Cochrane clinical controlled trials,MEDLINE,EMBASE,Wanfang,VIP,and ongoing trials databases,and full texts and reference lists were *** no study directly compared patients with dif-
Objective Little is known about the optimal cut-point of fasting plasma glucose for the diagnosis of Gestational Diabetes Mellitus(GDM) in Chinese pregnant *** study investigates the relationship between gestational f...
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Objective Little is known about the optimal cut-point of fasting plasma glucose for the diagnosis of Gestational Diabetes Mellitus(GDM) in Chinese pregnant *** study investigates the relationship between gestational fasting plasma glucose and neonatal birth weight,prenatal blood pressure and dystocia of pregnant *** hope to provide a useful tool to screen GDM in Chinese pregnant women. Methods For 1058 pregnant women enrolled in our hospital at their 22nd to 30th pregnancy weeks,their fasting plasma
Objective To determine the clinical characteristics of metabolically healthy obese(MHO) individuals with nonalcoholic fatty liver disease(NAFLD),and to explore the value of NAFLD on the risk of incident metabolic abno...
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Objective To determine the clinical characteristics of metabolically healthy obese(MHO) individuals with nonalcoholic fatty liver disease(NAFLD),and to explore the value of NAFLD on the risk of incident metabolic abnormal diseases in MHO individuals. Methods 4076 subjeets were evaluated for routine health examination in Peoples Hospital of Hunan Province from April 2006 to January 2010,2830 individuals were enrolled excluding
Background and aim The estimated glomerular filtration rate（eGFR） is thought to be an important and accessible index for the assessment of renal *** eGFR level less than 90 mL/min/1.73 m significantly increased the ...
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Background and aim The estimated glomerular filtration rate（eGFR） is thought to be an important and accessible index for the assessment of renal *** eGFR level less than 90 mL/min/1.73 m significantly increased the risk of chronic kidney *** study was aimed to explore the potential risk factors for a mildly reduced eGFR. Methods We undertook a cross-sectional study with 643 adults without a history of kidney disease whose eGFR levels were greater than 60 mL/min/1.73 m according to the Chronic
Background Estrogen receptor(ER)b2/bcx variant arises from alternative splicing of the last ERb *** appears that ERb2 lacks the AF-2 core region and does not bind to ERb ligands, but binds to estrogen responsive eleme...
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Background Estrogen receptor(ER)b2/bcx variant arises from alternative splicing of the last ERb *** appears that ERb2 lacks the AF-2 core region and does not bind to ERb ligands, but binds to estrogen responsive elements(EREs) as a homodimer and as a heterodimer with either wild-type ERa or *** relationship between the expression of ERb2 and clinicopathological factors has been widely studied in various can-
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