Clozapine was introduced in clinical treatment in early 1970s in China,Even the withdrawn from most European markets during 1970-90s,clozapine is continuously used from 1970s to update. And for many years clozapine wa...
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Clozapine was introduced in clinical treatment in early 1970s in China,Even the withdrawn from most European markets during 1970-90s,clozapine is continuously used from 1970s to update. And for many years clozapine was the first line treatment for psychosis and remains still one of the most commonly prescribed antipsychotic medications in *** its reintroduction into the United States in 1989,the use of clozapine is limited only to treat the refractory schizophrenia, and with compulsory hematological monitoring in order to reduce the risk of *** China clozapine is most commonly prescribed in low economic level regions and is still the most
It has been acknowledged that the major factors which influence the drug response are genetic *** are two drugs,*** and atomoxetine,approved for treatment of ADHD in *** recent decade,we were dedicated in the pharmaco...
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It has been acknowledged that the major factors which influence the drug response are genetic *** are two drugs,*** and atomoxetine,approved for treatment of ADHD in *** recent decade,we were dedicated in the pharmacogenomic research of both of these two *** identified NET(G1287A,hyperactive-impulsive symptoms improvements were 7.15,6.94,and 2.13 for G/G,G/A,and A/A genotypes respectively,P =.012 after multiple comparison correction),MAOA(30bp VNTR,T941G and C1460T,patients with
Almost 50%Of the patients with major depressive disorder(MDD) were resistant to adequate antidepressant trials(TRD).Recent repetitive transcranial magnetic stimulation(rTMS) was
Almost 50%Of the patients with major depressive disorder(MDD) were resistant to adequate antidepressant trials(TRD).Recent repetitive transcranial magnetic stimulation(rTMS) was
Objective Characterizing the relationship between drug dose and occupancy at its site of action in the brain is important for clinical practice and drug *** the absence of the information,patients may be treated with ...
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Objective Characterizing the relationship between drug dose and occupancy at its site of action in the brain is important for clinical practice and drug *** the absence of the information,patients may be treated with too low or too high a dose of drug and consequently risk receiving less than optimal treatment or experiencing unnecessary side *** emission tomography(PET) studies of drug-receptor occupancy can be used to assess dosing of psychotropic *** particular,this approach has been used to investigate antipsychotic drug treatment of schizophrenia measuring dopamine D2 receptor *** D2 receptor
Schizophrenia is characterized by disturbances of perception,emotion,social functioning and *** suggest that genetics,early environment,neurobiology,and psychological stress are important contributing ***,evidence sug...
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Schizophrenia is characterized by disturbances of perception,emotion,social functioning and *** suggest that genetics,early environment,neurobiology,and psychological stress are important contributing ***,evidence suggests that oligodendrocytes play an important role in the pathogenesis of ***-wide gene expression studies have found a deregulation of myelin-related genes in *** and neuroimaging studies have demonstrated a loss of oligodendrocytes and myelin abnormalities in the brains of schizophrenic ***,patients with various demyelination disorders often have psychotic symptoms,indicating a correlation between demyelination and *** addition,there is clinical and preclinical evidence that
Bipolar disorder is a severe and often relapsing mental disorder that is characterized by abnormal mood and behaviours that can dramatically impair *** the etiopathology is still largely unknown,treatments are general...
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Bipolar disorder is a severe and often relapsing mental disorder that is characterized by abnormal mood and behaviours that can dramatically impair *** the etiopathology is still largely unknown,treatments are generally symptomatic and response predictors are mostly clinical in *** and antiepileptic medications have been the mainstay of treatment of bipolar *** the last decade,data from atypical antipsychotic treatment trials in bipolar disorder have confirmed that atypical antipsychotic monotherapy is superior to placebo regarding an acute manic and mixed episode and for maintenance treatment in bipolar *** addition, some atypical antipsychotics benefit depressive ***,less treatment options are available to treat bipolar depression,which is a common and often prolonged and disabling
作者：
Keming GaoDepartment of Psychiatry
University Hospitals Case Medical CenterCase Western Reserve University School of MedicineClevelandOhio
Antipsychotics are indicated for schizophrenia,but some antipsychotics,especially atypical antipsychotics,have been approved for bipolar mania,bipolar depression,treatment-resistant major depressive disorder,and anxie...
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Antipsychotics are indicated for schizophrenia,but some antipsychotics,especially atypical antipsychotics,have been approved for bipolar mania,bipolar depression,treatment-resistant major depressive disorder,and anxiety *** addition to indication use of antipsychotics, the off-label use of antipsychotics in different psychiatric conditions is also very common. Our previous studies have shown that patients with schizophrenia,bipolar mania,bipolar
Recently accumulating evidence has supported the dysfunction hypothesis of NMDA-type glutamate receptor in *** on the glutamate hypothesis,the regulation of extracellular D-serine,an endogenous co-agonist of NMDA type...
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Recently accumulating evidence has supported the dysfunction hypothesis of NMDA-type glutamate receptor in *** on the glutamate hypothesis,the regulation of extracellular D-serine,an endogenous co-agonist of NMDA type glutamate receptor,may be a favorable target system for the development of novel *** research has focused on the synthesis,extracellular release,uptake and degradation steps of D-serine in mammalian
'Social Brain hypothesis' has been presented by Robin Dunbar,Professor of Evolutionary Anthropology,University of *** found that mammals who lived in the largest social group often had the largest neocortex to...
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'Social Brain hypothesis' has been presented by Robin Dunbar,Professor of Evolutionary Anthropology,University of *** found that mammals who lived in the largest social group often had the largest neocortex to brain ratio and suggested that the demands of group living selected for an increase in neocortex size.A large number of neuroimaging studies on 'Theory of Mind' revealed that 'Social Brain',the network of brain regions which are involved in understanding other people,includes the medial prefrontal cortex(mPFC),and suggested its disturbance may underlie various psychiatric *** the other hand,another hypothesis ' Emotional Brain' has been proposed by Joseph LeDoux,Professor of Neuroscience and
The ECNP Taskforce on Nomenclature of psychotropic medicines was established in 2010, driven by the need felt by ECNP and colleague colleges that the words used to decsribe psychotropic drugs should be *** the nomencl...
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The ECNP Taskforce on Nomenclature of psychotropic medicines was established in 2010, driven by the need felt by ECNP and colleague colleges that the words used to decsribe psychotropic drugs should be *** the nomenclature of psychotropic drugs will have a great *** the most superficial level,branding makes a *** may,for example,increase adherence to treatment as prescribed;currently many patients show a reluctance to take certain medication simply because of their *** use of the term antipsychotic may be quite stigmatizing,and misleading if your problem has nothing to do with *** a more fundamental level,re-thinking the words we use stimulates a reformulation
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