Deep brain stimulation has been used for treating medical refractory psychiatric disorders,such as obsessive-compulsive disorders,depression,drug addiction,anorexia nervosa and Tourette syndrome etc. Since 2006,we per...
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Deep brain stimulation has been used for treating medical refractory psychiatric disorders,such as obsessive-compulsive disorders,depression,drug addiction,anorexia nervosa and Tourette syndrome etc. Since 2006,we performed neucleus accombance(NAcc) for drug addiction(1 case),anorexia nervosa(16 cases),Tourette syndrome(4 cases),anxiety(2 cases).All of these patients have been followed up more than 1 year. Results Deep brain stimulation is effective therapy for drug addiction,anorexia nervosa and Tourette syndrome,especial for those patients with shorter history of *** some early stage
Objectives This study aims to examine the prescription pattern of atypical antipsychotics as augmentation strategies to increase antidepressant efficacy and clinical variables influencing their uses for patients diagn...
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Objectives This study aims to examine the prescription pattern of atypical antipsychotics as augmentation strategies to increase antidepressant efficacy and clinical variables influencing their uses for patients diagnosed with major depressive disorder during psychiatric admission. Methods Subjects were patients who diagnosed with major depressive disorder and admitted Chosun University Hospital from 2007 to *** prescription frequency of atypical antipsychotics as augmentation of antidepressant therapy was *** factors influencing on antipsychotics augmentation therapy were also examined by logistic regression
Phencyclidine(PCP),a noncompetitive N-methyl-D-aspartate(NMDA) receptor antagonist, increases locomotor activity in rodents and causes schizophrenia-like symptoms in humans. Although activation of the dopamine(DA...
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Phencyclidine(PCP),a noncompetitive N-methyl-D-aspartate(NMDA) receptor antagonist, increases locomotor activity in rodents and causes schizophrenia-like symptoms in humans. Although activation of the dopamine(DA) pathway is hypothesized to mediate these effects of PCP,the precise mechanisms by which PCP induces its effects remain to be *** investigated the effect of PCP on extracellular levels of DA(DA) in the striatum and prefrontal
Objective In the year of 2008 the number of drugs abuser has reached 3,362,506(1.99%of total population).Forty percents of them are *** existing number is still going to *** which are abused the most are heroin,amphet...
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Objective In the year of 2008 the number of drugs abuser has reached 3,362,506(1.99%of total population).Forty percents of them are *** existing number is still going to *** which are abused the most are heroin,amphetamine,methamphetamine,and *** the previous research conducted in one of junior high schools in Jakarta(2009),15% students had previously used *** addiction clinic Cipto Mangunkusumo Hospital on 2012, the case of canabis abuse covers 70%of total drugs abuse *** based of canabis use shows that memory,attention,and executive function disorder are ***-termed use of
OBJECTIVE This study was aimed at estimating the prevalence and distribution of autism spectrum disorders(ASD)-caused disability among Chinese children and adolescents based on a national population *** for this study...
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OBJECTIVE This study was aimed at estimating the prevalence and distribution of autism spectrum disorders(ASD)-caused disability among Chinese children and adolescents based on a national population *** for this study were derived from the Second China National Sample Survey on Disability. METHODS The Second China National Sample Survey on Disability was conducted from April 1 to May 31,***,multiphase,and cluster probability sampling was used in the
Objective In order to provide evidence for making strategy and measurement related to disability rehabilitation,prevalence of disability attributable to mental and behavioral disorders due to psychoactive substance an...
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Objective In order to provide evidence for making strategy and measurement related to disability rehabilitation,prevalence of disability attributable to mental and behavioral disorders due to psychoactive substance and its distribution in China were analyzed. Methods Using descriptive epidemiological method,the data of the Second National Sampling Survey on Disability in 2006 were analyzed to show prevalence rate of disability attributable to mental and behavioral disorders due to psychoactive substance and its distribution by population
The early detection of individuals who might develop psychosis has become a major interest of clinicians and researchers with the goal of improvement of the clinical *** the last 20 years,the concept of 'clinical ...
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The early detection of individuals who might develop psychosis has become a major interest of clinicians and researchers with the goal of improvement of the clinical *** the last 20 years,the concept of 'clinical high risk'(CHR) facilitated large amount of studies which identified the clinical risk factors and biomarkers that predict the onset of *** regard to early intervention however,the benefits and potential risks of pharmacological treatment in CHR state for psychosis has remained largely unclear,because of slower accumulation of research *** I will review the studies of antipsychotics treatment in CHR and share our experience from Seoul Youth Clinic in association with clinical symptoms and their
The S-allele of functional polymorphisms of the serotonin transporter(SERT) gene has been demonstrated to have lower transcriptional activity compared with the L-allele,which shows low expression of SERT in the ***,th...
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The S-allele of functional polymorphisms of the serotonin transporter(SERT) gene has been demonstrated to have lower transcriptional activity compared with the L-allele,which shows low expression of SERT in the ***,this finding cannot be consistently replicated in vivo. Importantly,the frequency of polymorphism is different from Asian and *** aim of this study was to determine the availability of SERT based on SERT genotype in an Asian *** also examined the relationship between brain-derived neurotrophic factor(BDNF) and the availability of ***-two healthy subjects were *** subject underwent single photon emission computed tomography(SPECT) with 123I-ADAM for imaging SERT in
Almost all antipsychotics have initially been developed for the treatment of schizophrenia, however,some antipsychotics,especially some atypical antipsychotics(second- generation antipsychotics) have been studied in t...
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Almost all antipsychotics have initially been developed for the treatment of schizophrenia, however,some antipsychotics,especially some atypical antipsychotics(second- generation antipsychotics) have been studied in the acute treatment bipolar mania,bipolar depression, bipolar maintenance,major depressive disorder(MDD),and anxiety *** all antipsychotics on the market for schizophrenia have been approved by regulatory agencies in different countries,their efficacy(effect size) in reducing positive and negative symptoms was different with clozapine,amisulpride,and olanzapine most effective and iloperidone,lurasidone, and asenapine least *** bipolar mania,risperidone and olanzapine were the most
Objective Several recent studies from indicated that domestic violence in childhood has not only in short-term but also in ling-term effects to the children through complex processes. Exposure to early life stress,tha...
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Objective Several recent studies from indicated that domestic violence in childhood has not only in short-term but also in ling-term effects to the children through complex processes. Exposure to early life stress,that is unfortunately common in the general population,has been shown to predict a wide range of psychopathology,including ***,heightened impulsivity has been identified as a risk marker for pathologic alcohol *** study was designed to investigate the correlation between early life stress and the characteristics of alcohol
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