The 'Depression Executive Dysfunction Syndrome' afflicts a considerable number of depressed elderly patients and may be resistant to conventional *** studied the Choline Alfoscerate or the ethyl ester of eicos...
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The 'Depression Executive Dysfunction Syndrome' afflicts a considerable number of depressed elderly patients and may be resistant to conventional *** studied the Choline Alfoscerate or the ethyl ester of eicosapentaenoic acid(E-EPA) as an adjunct to antidepressant treatment for episodes of depressive disorder occurring in older depressed patients(over 60 years old) with or without executive dysfunction. The design was a 12-week,parallel-group,double-blind addition of Choline Alfoscerate or E-EPA to ongoing antidepressant *** continued their current antidepressant
Backgound Opioid abuse is a worldwide *** to opioid abuse is widely accepted to have a close relationship to theμopioid receptor gene spesifically to A 118G polymorphism which varied 2-50%among the nations and C 17T ...
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Backgound Opioid abuse is a worldwide *** to opioid abuse is widely accepted to have a close relationship to theμopioid receptor gene spesifically to A 118G polymorphism which varied 2-50%among the nations and C 17T *** Indonesia,study of A 118G and C 17T polymorphismsμopioid receptor gene had never been conducted. Objectives To see the distribution of A 118G and C 17 ofμopioid receptor gene
OBJECTIVE Although monoamine oxidase inhibitors(MAOIs) are no longer first-line drugs for treatment of depression,there has been renewed interest in these drugs due to reports of their neuroprotective properties in a ...
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OBJECTIVE Although monoamine oxidase inhibitors(MAOIs) are no longer first-line drugs for treatment of depression,there has been renewed interest in these drugs due to reports of their neuroprotective properties in a wide variety of in vivo and in vitro models,suggesting that they may also be useful drugs for treating certain aspects of neurodegenerative *** MAOI phenelzine(phenylethylhydrazine) and a metabolite of phenelzine,namelyβ-phenylethylidenehydrazine(PEH),have been shown to possess both neuroprotective and
Aversive memories associated with drug withdrawal may contribute to persistent drug seeking. Molecular mechanisms that are critical for aversive memory formation have yet to be elucidated. Recently,we showed in a rat ...
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Aversive memories associated with drug withdrawal may contribute to persistent drug seeking. Molecular mechanisms that are critical for aversive memory formation have yet to be elucidated. Recently,we showed in a rat conditioned place aversion(CPA) model that synaptic actin polymerization in the amygdala were required for aversive memory ***,we demonstrated that actin polymerization within the amygdala triggered transportation of activity-regulated cytoskeletal-associated protein(Arc/Arg3.1) into amygdalar synapses.
Current treatment for attention deficit hyperactivity disorder(ADHD) has limited efficacy for frequently comorbid oppositional defiant disorder(ODD).N-methyl-D-aspartate(NMDA) receptor activity,playing a vital role in...
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Current treatment for attention deficit hyperactivity disorder(ADHD) has limited efficacy for frequently comorbid oppositional defiant disorder(ODD).N-methyl-D-aspartate(NMDA) receptor activity,playing a vital role in mood modulation,can be a potential target of drug development for such *** study aims to assess the efficacy and safety of an endogenous glycine transporter-1(GlyT-1) inhibitor,sarcosine(N-methylglycine),for treatment of ADHD in *** hundred and sixteen children were enrolled in a 6-week,randomized,double-blind clinical trial to receive sarcosine(0.03 gm/kg/day) or *** primary outcome measures included inattention,hyperactivity/impulsivity,and oppositional defiant disorder(ODD) subscales of Swanson,Nolan,and Pelham,version IV scale(SNAP-IV-C).Sarcosine surpassed
Objective The development of long-acting injectable(LAI) antipsychotics aims to tackle the challenging issue of adherence in treatment of psychotic *** controlled trials, however,are likely to selectively recruit adhe...
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Objective The development of long-acting injectable(LAI) antipsychotics aims to tackle the challenging issue of adherence in treatment of psychotic *** controlled trials, however,are likely to selectively recruit adherent patients and could not differentiate the difference between LAI and oral forms of *** observational study with national database in Taiwan was to assess the economic effectiveness of risperidone long-acting injection (RLAI) in the real-world clinical practice. Method We analyzed the health service uses and costs in a cohort of schizophrenia from the
Objective To explore facial expression recognition impairment in patients with the first-episode schizophrenia and its relationship with executive function. Methods There were 30 first-episode schizophrenia,26 high-ri...
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Objective To explore facial expression recognition impairment in patients with the first-episode schizophrenia and its relationship with executive function. Methods There were 30 first-episode schizophrenia,26 high-risk individuals and 30 healthy controls who completed facial emotion recognition tasks from the Ekman Standard Faces Database,and executive function measured by the Wisconsin Card Sorting Test (WCST).Regression analyses were conducted to assess association between facial recognition disorder and executive function. Results Recognition of facial expression was impaired in first-episode schizophrenia and high-risk groups both in measures of accuracy and reaction *** healthy controls did not
Objeetive Clinicians encounter tremendous challenges in the face of treatment refractory patients(including those who relapse because of poor-adherence and those who have poor response even on medication).There are co...
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Objeetive Clinicians encounter tremendous challenges in the face of treatment refractory patients(including those who relapse because of poor-adherence and those who have poor response even on medication).There are consistent data supporting the use of clozapine when other drugs ***,the utilization rates of clozapine are various across countries.A major factor contributing to relapse is non-adherence in medication *** there is some debate regarding the superiority of long acting injectable antipsychotics(LAIs) in comparison to oral medications,there is reason to believe that,for some patients,the use of such formulations could go a long way towards relapse *** more and more emphasis is placed on evidence-based medicine and the implementation of guidelines,it is important for us to recognize
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