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Management of major depressive disorder after an inadequate response to first-line treatment

Management of major depressive disorder after an inadequate ...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Chia-Yih Liu Department of Psychiatry Chang Gung Medical Center at Linkou Department of PsychiatryChang Gung University School of Medicine

Thirty to 50%of people with major depressive disorder do not respond(or partial respond) to the usual recommended dose of first line *** following strategies should be adopted for managing treatment resistant depression:[Step 1].Re-evaluation of the diagnosis. For example,bipolar disorder,delusional disorder or even organic depression should be ruled out. [Step 2].Evaluation of the patient's compliance/*** adherence was noted in 25-28% patients with MDD within one month,and over 40%within 3 *** adherence estimated to account for 20%of treatment resistant cases.[Step 3].Reappraising the treatment regimen. Current guidelines recommend several strategies for the management of inadequate responder of MDD:Switching to a different antidepressant for non responder;add-on treatment for partial

关键词： agent Management of major depressive disorder after an inadequate response to first-line treatment

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女性精神分裂症患者社会快感缺失与述情障碍的相关性

女性精神分裂症患者社会快感缺失与述情障碍的相关性

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者：马玉婷董毅安徽医科大学安徽省精神卫生中心

目的快感缺失(Anhedonia)是指对快乐的体验能力下降,是精神疾病的一个重要特征,也是精神分裂症患者最常见的阴性症状之一。社会快感缺失主要侧重于从社会人际交往方面进行考察。述情障碍(alexitymia)是对自身情感缺乏描述能力的一种障碍... 详细信息

目的快感缺失(Anhedonia)是指对快乐的体验能力下降,是精神疾病的一个重要特征,也是精神分裂症患者最常见的阴性症状之一。社会快感缺失主要侧重于从社会人际交往方面进行考察。述情障碍(alexitymia)是对自身情感缺乏描述能力的一种障碍,研究证实精神分裂症患者在区分情感体验和情绪唤醒所引起的躯体感受存在困难。本研究旨在探讨女性精神分裂症患者社会快感缺失程度,及其与述情障碍间的关系。方法对象为安徽省精神卫生中心住院的94例女性精神分裂症患者(患者组),急性发病期,至少近一个月未用抗精神病药物,排除检查不合作或严重躯体疾病者。对照组为年龄、性别和受教育年限相匹配的107例男性精神分裂症患者及167例女性健康者。所有对象完

关键词：快感缺失女性精神分裂症精神分裂症患者

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Proficiency Testing on Forensic Psychiatry in Chin

Proficiency Testing on Forensic Psychiatry in Chin

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者：张钦廷蔡伟雄刘超司法部司法鉴定科学技术研究所

目的目前缺乏对于司法精神病学鉴定检查的开展、鉴定意见的出具、鉴定报告的书写等关键环节的评价方案、机制和对机构的鉴定能力进行比较、监督、规范的有效手段和途径。本文探讨在中国司法精神病学开展能力验证活动的可行性。方法从能... 详细信息

目的目前缺乏对于司法精神病学鉴定检查的开展、鉴定意见的出具、鉴定报告的书写等关键环节的评价方案、机制和对机构的鉴定能力进行比较、监督、规范的有效手段和途径。本文探讨在中国司法精神病学开展能力验证活动的可行性。方法从能力验证活动的主要因素出发,以2009年司法精神病学能力验证活动经验为基础,

关键词：司法精神病学鉴定刑事责任能力鉴定意见能力验证活动 Proficiency Testing on Forensic Psychiatry in Chin

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A PhaseⅡRandomized,Double-Blind,Placebo-Controlled Trial of GLYX-13 for the Rapid Treatment of Major Depressive Disorder using Central Ratings

A PhaseⅡRandomized,Double-Blind,Placebo-Controlled Trial of...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Danielle Popp Ronald Burch Janet BW Williams Michael J Detke Department of Psychiatry Indiana University

Objective N-methyl-D-aspartate(NMDA) receptor ligands have been shown to rapidly treat depression but are associated with psychotomimetic ***-13(ThrProProThr-amide) is an NMDA receptor glycine site functional partial agonist with～25%of the agonist activity of glycine or *** models suggest a single intravenous dose may produce long-term efficacy without psychotomimetic effects.A phase II randomized,double-blind, placebo-controlled trial was conducted to assess the efficacy of GLYX-13 in subjects with inadequate response to previous treatment for major depressive disorder(MDD).This study examines the use of remote blinded independent Central Ratings to assess the efficacy and safety of a putative rapid onset intravenous antidepressant(GLYX-13) with a study design utilizing frequently repeated psychiatric assessments.

关键词： A Phase Randomized,Double-Blind,Placebo-Controlled Trial of GLYX-13 for the Rapid Treatment of Major Depressive Disorder using Central Ratings

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Association study of 42 SNPs within 10 candidate genes for mood disorders

Association study of 42 SNPs within 10 candidate genes for m...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Chi-Un Pae CUMC

The aim of this study is to investigate a set of single nucleotide polymorphisms (SNPs) within 10 candidate genes for their possible association with clinical outcomes for major depression(MD),bipolar disorder(BD),and response to antidepressants and mood stabilizers,in a sample of Korean *** hundred forty-five(145) in-patients suffering from MD,132 in-patients suffering from BD,and 170 psychiatrically healthy controls were genotyped for 42 SNPs within genes ABCBl,ABCB4,TAP2,CLOCK,CPLXl,CPLX2,SYN2,NRGl,5HTR1A, and *** and final clinical measures,including the Hamilton Rating Scale for Depression(HAMD) and the Young Mania Rating Scale(YMRS),were *** did not observe any significant association between the genetic variants investigated in the present study and the clinical *** findings preliminarily suggest the lack of influence of the 42 investigated SNPs on MD and BD susceptibility and on the response to pharmacological treatments of these ***,taking into account the several limitations of our study, further research is needed to draw more definitive conclusions.

关键词： Association study of 42 SNPs within 10 candidate genes for mood disorders

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Lithium stimulates chemokine production in monocytic cells

Lithium stimulates chemokine production in monocytic cells

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Zhiqian Yu Chiaki Ono Ichiro Sora Hiroaki Tomita Department of Disaster Psychiatry IRIDeS Tohoku University Tohoku Medical Megabank Organization Tohoku University Department of Biological Psychiatry Graduate School of MedicineTohoku University

Lithium,a direct inhibitor of glycogen synthase kinase 3(GSK-3),has been widely prescribed mood stabilizer in treatment of bipolar *** suggests that lithium affects monocytic cells,which play pivotal roles in the innate immune systems in both the brain and peripheral *** major studies into the mechanism of action of lithium has been focused on neuron,astrocyte and oligocyte,recent studies indicate that lithium and GSK-3 inhibition also affect immune cells,such as peripheral monocytes,macrophages, monocyte-derived dendritic cells and *** and GSK-3 inhibition are shown to mediate inflammation,microglial migration,monocyte-derived dendritic cells differentiation and reverse monocytic malfunction observed in neuropsychiatric *** confirmed the lithium significantly increased the chemokine production via GSK-3 inhibition in the mouse and human monocytic *** data suggest that clinical treatment of lithium via GSK-3 inhibition by increasing chemokine expression in central/peripheral differentiation monocytic cells directly associate to immune defense system.

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The Effect of Fluoxetine on Behaviors in Transient Forebrain Ischemic model in Gerbil

The Effect of Fluoxetine on Behaviors in Transient Forebrain...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Do Hoon Kim

Objective This study aims to explore the effect of fluoxetine on memory, locomotor and depressive behavior in transient forebrain ischemic model of gerbil. Methods The two doses of fluoxetine(10,40 mg/kg) or vehicle were intraperitoneally administered once 30 min before ischemic surgery in *** object recognition test, spontaneous motor activity,learned helplessness test were performed 4 days,8 days,or 9 days, respectively,after sham or ischemic surgery. Results Fluoxetine treatment(40 mg/kg) significantly reduced recognition memory in sham operated ***,fluoxetine(10,40 mg/kg) did not affect ischemia-induced impairment in recognition *** treatment of fluoxetine(10,40 mg/kg) significantly inhibited locomotor hyperactivity induced by transient ischemia even though fluoxetine(40 mg/kg) did not affect spontaneous motor activity in the sham operated *** did not affect depressive behavior in sham and ischemic gerbils. Conclusion The treatment of fluoxetine inhibited ischemia - induced hyperactivity,but did not affect memory and depressive behavior in transient forebrain ischemic gerbils.

关键词： The Effect of Fluoxetine on Behaviors in Transient Forebrain Ischemic model in Gerbil

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Comparison of plasma neuregulin 1 immunoreactivity in control subjects and patients with distinct psychiatric diseases

Comparison of plasma neuregulin 1 immunoreactivity in contro...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Ran Wang Lulu Yu Lan Wang Xueyi Wang Department of Psychiatry the First Hospital of Hebei Medical University

Objectives Neuregulin-1(NRG1) is implicated in the etiology or neuropathology of various psychiatric diseases such as schizophrenia and major depression,although its biological contribution to the individual diseases is not fully *** evaluate the pathological influences of individual psychiatric diseases on plasma NRG1,we employ an enzyme-linked immunosorbent assay(ELISA) for *** measure NRG1 immunoreactivities in blood plasma of patients with chronic schizophrenia,bipolar disorder,major depression as well as those of healthy *** also attempt to estimate the contribution of single nucleotide polymorphisms(SNPs) ofNRG1 gene to plasma NRG1 levels. Methods We collect plasma of patients with chronic schizophrenia(n =～20),bipolar disorder (n =～20),major depression(n =～20) and healthy volunteers(n =～20).SNPs of NRG1 are genotyped using the TaqMan *** and gender will be matched among *** present study was approved by the Ethics Committee at the First Hospital of Hebei Medical University, and written informed consent was obtained from all participants.

关键词： Comparison of plasma neuregulin 1 immunoreactivity in control subjects and patients with distinct psychiatric diseases

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Increased prevalence of clinical depression in elderly Chinese subjects with cardiovascular diseases

Increased prevalence of clinical depression in elderly Chine...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Mei Song Yumei Wang Shunjiang Xu Xueyi Wang Department of Psychiatry the First Hospital of Hebei Medical University

Objective We measured the prevalence of CVD and depression in elderly Chinese citizens living in the community to establish a foundation for a comprehensive CVD treatment and prevention program. Methods We constructed a questionnaire to assess the most frequent CVDs in the community elderly and used the Center for Epidemiology Scale-Depression(CES-D) self-report survey to evaluate the coincidence of depression. Results Among the 3176 participants,the most prevalent CVDs were hypertension(1414/3171, 44.6%),hyperlipidemia(727/3092,23.4%),coronary heart disease(554/3098,17.7%),and angina pectoris(276/3094,8.8%).These CVDs were either more frequent in females,for example,*** symptoms were significantly more prevalent in elderly subjects with angina pectoris,CHD and hypertension,but not hyperlipidemia or arrhythmia. Logistic regression analysis suggested that older age,higher alcohol consumption,and angina were predictors of depression in elderly CVD patients. Conclusions The prevalence of depression is significantly higher in elderly Chinese individuals with angina pectoris,CHD,or hypertension than in the general elderly *** associated with these CVDs may contribute to depression,while depression may exacerbate CVD.

关键词： Increased prevalence of clinical depression in elderly Chinese subjects with cardiovascular diseases

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Effectiveness of duloxetine monotherapy compared to combination therapy with other antidepressants in patients with anxiety or depressive disorders:A comparison between male and female patients

Effectiveness of duloxetine monotherapy compared to combinat...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Jun-Yeob,Lee Jeong-Kyu,Sakong Eun-Jin,Cheon Sung-Won,Jung CHA Gumi Medical Center Psychiatry Keimyung University Dongsan Medical Center Psychiatry Dongguk University Gyeongju Hospital Psychiatry Yeungnam University Medical Center Psychiatry

Objective Duloxetine is an antidepressant that effects a serotonergic and noradrenergic neurotransmitter,and a useful agent in the treatment of the patients with anxiety or depressive *** to the recently reported study results,combination therapy with 2 antidepressants in the treatment of patients with major depressive disorders did not show a superior efficacy but did show the more adverse events than *** purpose of this study was to evaluate sex differences in effectiveness of duloxetine monotherapy compared to combination therapy with other antidepressants in patients with anxiety or depressive disorders.

关键词： CGI Effectiveness of duloxetine monotherapy compared to combination therapy with other antidepressants in patients with anxiety or depressive disorders:A comparison between male and female patients

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