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Escitalopram in long-term treatment of major depressive disorder with associated anxiety symptoms:a single-arm,open-label multicenter trial in Chinese population.

Escitalopram in long-term treatment of major depressive diso...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Kaida Jiang Maosheng Fang Shanghai Mental Hospital

OBJECTIVE The aim of the study was to evaluate the efficacy and safety of long term escitalopram treatment in Major Depressive Disorder(MDD) in Chinese patients with associated anxiety symptoms and assess the effect of baseline degree of anxiety on treatment response. METHOD This was a 24-week,single-arm,open-label,multicenter,prospective,long-term *** and female adults(n = 318) aged 18-65 years,inclusive with Diagnostic and Statistical Manual of Mental Disorders,Fourth Edition,text-revision(DSM-1V-TR) criteria-defined major depressive disorder(minimum Montgomery Asberg Depression Rating scale[MADRS]total score of 22) with anxiety symptoms(minimum Hamilton Anxiety Rating scale[HAM-A]total score of 14) received treatment with escitalopram l0 to 20 mg/*** primary efficacy parameter was the remission rate(defined as MADRS<10 and HAM-A<7) at

关键词： Escitalopram in long-term treatment of major depressive disorder with associated anxiety symptoms:a single-arm,open-label multicenter trial in Chinese population

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Perceived Stress,Coping Strategy and Psychopathology Among HIV SeropositivePeople who Injecting Drug(PWID) in Working Group on AIDS CiptoMangunkusumo Hospital,Scientific Light Foundation on HIV,TebetPrimary Health Center and KiosAtmajaya University Jakarta

Perceived Stress,Coping Strategy and Psychopathology Among H...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Khamelia Nurmiati Amir SuryoDharmono Department of Psychiatry Faculty of MedicineUniversity of Indonesia

Introduction Indonesia with population of 237.5 million has been estimated HIV prevalence of 0.27%among the 15-49 years age ***'s HIV and AIDS epidemic is concentrated amongst key affected population resulting from a mix of two modes of transmission and drug *** cumulative report HIV cases shows infection from injecting use is 36%.Further analysis shows that the proportion of People Who Inject Drugs(PWID) who infected in their first year of engagement is high overtime(2007 and 2011) at 27%and 13%.Percentage of PWID that have received an HIV test in the last 12 months and who know their result is 90.6%.Only 67%

关键词： HIV/AIDS PIWD patients coping psychopathology perceived stress

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The effects of albumin and white matter hyperintensity on cognitive function in the elderly

The effects of albumin and white matter hyperintensity on co...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Kang Soo Lee Sang Joon Son Chang Hyung Hong AJou university

Low albumin level and subcortical ischemic changes might be associated with cognitive performance in the *** examined the relationship between albumin level,white matter hyperintensity(WMH) and cognitive function among 1038 old adults who were evaluated at the Clinical Research Center for Dementia of South *** samples were drawn from all consenting subjects,and an albumin level was treated as a categorical variable based on quartile. Cognitive function was assessed by the Korean version of Mini Mental State Examination (K-MMSE).We also evaluated the severity of WMH as mild and sever level on brain MRI *** a multivariable adjustment,we could found significant differences in K-MMSE score among albumin level groups(F=6.5,p <0.001) but not between WMH mild and severe groups(t=0.2,p = 0.827),***,the interaction between albumin level and the severity of WMH was shown to be significantly associated with cognitive function(analysis of covariance,F=3.8,p = 0.010).In post hoc tests,a higher K-MMSE score was rather observed in subjects with higher albumin level and severe *** albumin level with severe subcortical ischemic changes appears to be related to cognitive function in old adults.

关键词： The effects of albumin and white matter hyperintensity on cognitive function in the elderly

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缓解期精神分裂症患者应对方式、父母教养方式及与心理年龄的相关性

缓解期精神分裂症患者应对方式、父母教养方式及与心理年龄的相关...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

目的了解缓解期精神分裂症患者的应对方式、父母教养方式以及与心理年龄的相关性,为缓解期精神分裂症患者的心理干预提供科学依据。方法采用自编一般情况问卷、应付方式问卷、防御方式问卷、及心理年龄评估问卷(此问卷根据埃里克森的心... 详细信息

目的了解缓解期精神分裂症患者的应对方式、父母教养方式以及与心理年龄的相关性,为缓解期精神分裂症患者的心理干预提供科学依据。方法采用自编一般情况问卷、应付方式问卷、防御方式问卷、及心理年龄评估问卷(此问卷根据埃里克森的心理发展观对不同年龄发展阶段的发展任务的描述改编而成,共分为婴儿期(0～2岁)、幼儿期(2～4岁)、学龄前期(4～7岁)、学龄期(7～12岁)、青年期(12～18岁)、成年早期(18～25岁)、成年中期(25～50岁)、老年期(50岁～死亡)共8个期。根据患者调查前1个月的表现从心智水平、处理问题的方式方法、情感的稳定程度等进行全面评定,先确定患者的心理特点在哪个阶段,再根据言语、情绪、行为、动机、

关键词：缓解期精神分裂症心理年龄应对方式父母教养方式

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儿童精神分裂症外周血白细胞LncRNA表达谱分析

儿童精神分裂症外周血白细胞LncRNA表达谱分析

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者：徐勇李忻蓉孙宁胡晓东张克让山西医科大学第一医院山西医科大学心理卫生研究所

目的儿童精神分裂症神经发育异常的可能性更大。本研究拟以精神分裂症儿童患者及精神分裂症前驱期儿童外周血白细胞筛选进行精神分裂症特异的lncRNAs的筛选。方法样本纳入与排除:精神分裂症入组标准(组1):11岁≤年龄≤15岁;汉族;患者符... 详细信息

目的儿童精神分裂症神经发育异常的可能性更大。本研究拟以精神分裂症儿童患者及精神分裂症前驱期儿童外周血白细胞筛选进行精神分裂症特异的lncRNAs的筛选。方法样本纳入与排除:精神分裂症入组标准(组1):11岁≤年龄≤15岁;汉族;患者符合DSM-Ⅳ关于精神分裂症的诊断标准;阳性与阴性症状量表量表(PANSS)评分>60分;儿童韦氏智力测验IQ>70分。未经治疗、首发儿童精神分裂症;家属或监护人同意参加本研究。排除标准:患有重大躯体疾病或有颅脑外伤史;头颅CT和脑电图提示:先天畸形等神经系统疾病;患者有精神发育迟滞和全面发育障碍。入组前4周服用任何精神科药品治疗者等。精神分裂症前驱期入组标准(组2):年龄性别与病例组相匹配;使用精神病

关键词：儿童精神分裂症精神分裂症患者 LncRNA 外周血白细胞

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Clinical features in bipolar patients who have been misdiagnosed

Clinical features in bipolar patients who have been misdiagn...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Xu guiyun Chen xiaodong Guangzhou psychiatric hospital

Objective Bipolar disorder is usually *** study aims to probe the clinical features in bipolar patients who have ever been misdiagnosed as other types of affective disorder. Methods Seven hundred and thirteen consecutive patients with clinical diagnoses of affective disorder were evaluated using a Chinese version of SCID-I/*** collected demographic information and clinical features on these patients,asked them to complete a 15-item checklist about prior symptoms of hypomania(HCL-15),and administered the Hamilton Depression Rating Scale(HAMD-17).Univariate logistic regression and multivariate forward stepwise logistic regressions were performed to identify factors associated with misdiagnosis of bipolar disorder. Results Two hundred and eighty two patients were identified as bipolar *** them, 56.7%(160/282) of patients had been misdiagnosed as other types of mental *** following clinical features were more prevalent in patients who had been misdiagnosed:more initial syndrome as depression,more first onset,more melancholic feature,more bipolarⅡdisorder,more hypomanic symptoms;In multivariate analysis,the following variables related to misdiagnosed of BD:greater age(OR=1.03),more first onset(OR = 6.19),more initial syndrome as depression(OR = 2.67),more bipolarⅡdisorder(OR = 2.09). Conclusion Misdiagnosis of bipolar disorder is common,when facing first onset patients with depression,it's necessary to probe the history of hypomania symptoms.

关键词： Clinical features in bipolar patients who have been misdiagnosed

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Mismatch negativity is a stronger indicator of functional outcomes than neurocognition or theory of mind in patients with schizophrenia

Mismatch negativity is a stronger indicator of functional ou...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Seung-Hwan Lee Inje University

Background Mismatch negativity(MMN) is known to be associated with neurocognition,social cognition,and functional *** present study explored the relationships of MMN with neurocognition,theory of mind,and functional outcomes in patients with schizophrenia,the first-degree relatives of patients with schizophrenia,and healthy controls. Methods Twenty-five patients with schizophrenia,21 first-degree relatives of patients with schizophrenia,and 29 healthy controls were *** examined symptom severity, neurocognition,theory of mind,functional outcomes,and the MMN. Results Mismatch negativity amplitudes decreased in order of patients with schizophrenia,then first-degree relatives,then healthy *** negativity amplitude was significantly correlated with measures of neurocognition,theory of mind,and functional outcome measurements in patients with ***,the most powerful correlations were those between MMN in the frontal region and measures of functional *** power and frequency of the correlations were weaker in first-degree relatives and healthy controls than in patients with *** regression analysis revealed that functional outcomes (relative to measures of neurocognition and theory of mind) constituted the most powerful predictor of mismatch negativity. Limitations:Relatively small sample size has weakened the power of our results.. Conclusion Our results suggested that mismatch negativity reflects functional outcomes more efficiently than do measures of neurocognition and theory of mind in patients with schizophrenia.

关键词： Mismatch negativity is a stronger indicator of functional outcomes than neurocognition or theory of mind in patients with schizophrenia

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The Differentiation between Patients with Depression and Schizophrenia by means of the PAI

The Differentiation between Patients with Depression and Sch...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Min Cheol Park Sang Woo Oh Wonkwang Univ Hosp

Objective This study was to investigate the differentiation between patients with depression and schizophrenia by means of the PAI(Personality Assessment Inventory Korean version:Kim Young-Hwan et al.,2001).It was hypothesized that groups of patients with depression and schizophrenia would be the various differences in full scales score of the PAI. Method Subjects were 146 patients with depression,207 patients with *** the age of 18 to 60 visiting the department of psychiatry at the Wonkwang university hospitals located in countryside from January of 2010 till December of *** a study method,PAI full scales were used to conduct descriptive statistics,t-test and estimates of effect size. Results The results were as *** score of NIM scale in patients with depression were higher than schizophrenia and the score of PIM scale in patients with depression were lower than *** scores of SOM,ANX,ARD,DEP in the clinical scales of the PAI in patients with depression were higher than schizophrenia and the score of MAN,PAR,ANT in patients with depression were lower than *** scores of SUI,STR in the therapeutic scales of the PAI in patients with depression were higher than schizophrenia and the score of RXR in patients with depression were lower than *** score of DOM in the interpersonal scales of the PAI in patients with depression were lower than schizophrenia. Conclusion Results of this study groups between patients with depression and schizophrenia were significant *** limitations of this study and suggested directions for future research were discussed.

关键词： The Differentiation between Patients with Depression and Schizophrenia by means of the PAI

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Association between an opioid receptor-related gene polymorphism and smoking in Japanese

Association between an opioid receptor-related gene polymorp...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Shinya Kasai Daisuke Nishizawa Junko Hasegawa Naomi Sato Fumihiko Tanioka Haruhiko Sugimura Kazutaka Ikeda Addictive Substance Project Tokyo Metropolitan Institute of Medical ScienceJapan First Department of Pathology Hamamatsu University School of MedicineJapan Department of Pathology Iwata City HospitalJapan

Objective The endogenous opioid system has been reportedly implicated in tobacco/nicotine *** genetic contributions to smoking-related phenotypes are approximately 0.3-0.8, indicating that genetic polymorphisms can be markers for individual vulnerability to smoking. However,racial and ethnic differences of genetic polymorphisms lead to different effect sizes in the analyses and would be expected to affect the results of association *** the present study,we examined the genetic effects of single nucleotide polymorphisms(SNPs) in the genes related to signal transduction of opioids on smoking status and smoking-related traits in Japanese. Methods This study included 1,000 subjects who were treated in Iwata City *** participants completed a questionnaire that contained questions about smoking status and smoking-related *** SNPs genotyping was performed by real-time polymerase chain reaction or a direct sequencing *** associations between variances of SNPs and smoking status and smoking-related traits were statistically evaluated using non-parametric

关键词： Association between an opioid receptor-related gene polymorphism and smoking in Japanese

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A self-reported survey on sleep problems in Chinese illicit drug abusers:comparison with non-drug-using controls

A self-reported survey on sleep problems in Chinese illicit ...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Yanhui Liao Quansheng Tang Qijian Deng Guanbai Zhang Chang Qi Hangtao Cui Bin Jiao Xiaogang Chen Wei Hao Tieqiao Liu Jinsong Tang Institute of Mental Health the Second Xiangya Hospital of Central South University Nanning Red Cross Hospital Yunnan Institute for Drug Abuse Department of Psychiatry Hunan Brain Hospital Department of Neurology Xiangya HospitalCentral South University

Aims This cross-sectional study explored sleep quality in illicit drug abuse subjects in China. Design,setting,and measurements 1537 illicit drug abuse subjects from drug rehabilitation centres(Hunan Province,Changsha City,China) and 1444 non-drug-using subjects completed the self-report Pittsburgh Sleep Quality Index(PSQI). Results We found that the prevalence of sleep disturbance was much higher in drug users (67.5%,PSQI>5) than nondrug users(25.6%,PSQI>5),and that these drug abusers used longer drugs and had poor sleep *** users had approximate twice sleep latency than nondrug

关键词： A self-reported survey on sleep problems in Chinese illicit drug abusers:comparison with non-drug-using controls

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