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A Cross-cultural Study of Family Functioning in Non-clinical Couples between North America and China

A Cross-cultural Study of Family Functioning in Non-clinical...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者：王继堃 Abigail K.Mansfield Gabor Keitner 赵旭东同济大学附属东方医院临床心理科 Warrren Alpert Medical School of Brown University ProvidenceRI

There could be some differences in healthy family functioning across cultures,and culture could have an influence on family functioning of *** purpose of the current study is to explore the differences of family functioning,social support and quality of life among a community sample between North American and Chinese *** study examined the characteristics of family functioning,social support and quality of life in non-clinical couples in an American sample(N=51) and a Chinese sample(N=51).The results indicate all the dimensions of family functioning of American couples were in the healthy range,and most dimensions of family functioning of Chinese couples were in the healthy range except Behavioral *** were significant differences of Behavioral Control between American couples and Chinese ***,there was good agreement of family functioning among Chinese couples while less agreement of family functioning among North American ***,the quality of life for American wives was positively related with the social support from family and friend while the quality of life for Chinese wives was positively related with the social support from significant *** from the present study suggest that there are different characteristics of family fiinctioning in North American and Chinese couples.

关键词： A Cross-cultural Study of Family Functioning in Non-clinical Couples between North America and China

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血清S100B蛋白、TOC、MDA对利培酮治疗首发未服药精神分裂症患者疗效的影响

血清S100B蛋白、TOC、MDA对利培酮治疗首发未服药精神分裂症患者...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者：李艳丽谭云龙杨甫德陈松王志仁谭淑平杨贵刚李佳王月婵于欣周东丰北京回龙观医院北京大学精神卫生研究所

近年来,随着新的生物学技术的介入,在探索精神分裂症的病因及发病机理、精神症状的神经生物学过程等方面取得一定进展,但并无重大突破。诸多研究提示,神经元保护-损伤因素的失衡在疾病发生发展过程中作用关键。S100B是一种Ca结合蛋白,... 详细信息

近年来,随着新的生物学技术的介入,在探索精神分裂症的病因及发病机理、精神症状的神经生物学过程等方面取得一定进展,但并无重大突破。诸多研究提示,神经元保护-损伤因素的失衡在疾病发生发展过程中作用关键。S100B是一种Ca结合蛋白,主要由星型胶质细胞产生和分泌,对神经系统的发育和功能维持起重要作用,脑脊液或血清中S100B浓度升高是神经元破坏的一个敏感性的标志,它的升高提示胶质细胞的活化、神经元的死亡或血脑屏障受损。有学者发现在精神分裂症患者中血清S100B的浓度升高,而且与精神病理症状有关。而自由基含有不配对的电子,在人体内的正常生理代谢中产生,但自由基产生过量会导致细胞功能异常,细胞膜完整性受损,乃至细胞死亡。静息状态下,大脑耗氧量约占心脏输出氧的20%,且含有大量不饱和脂肪酸,儿茶酚胺自身氧化产生自由基,因而大脑容易受自由基损伤。有研究提示,S100B和机体抗氧化系统协同作用,影响患者的精神病理症状。目的①探讨首发未服药精神分裂症患者血清S100B蛋白、丙二醛(Malondialdehyde,MDA)浓度和总抗氧化能力(Total anti-Oxidant Capacity,TOC)变化;分析这些生化指标间的关联及与精神病理症状的关系;②比较利培酮治疗前后血清S100B蛋白、MDA浓度和TOC的变化;③探索基线血清S100B蛋白、TOC、MDA对利培酮治疗首发未服药精神分裂症患者疗效的影响。方法共纳入首发未服药精神分裂症患者61例(疾病组),健康对照66名(对照组);疾病组采用可变剂量利培酮单药治疗8周,分别于治疗基线、第2、4、8周采用阴性和阳性症状(Positive and negative symptoms scale,PANSS)量表评定患者精神病理症状;并于治疗基线和治疗结束取空腹静脉血,采用酶联免疫吸附(Enzyme-Linked ImmunoadsordentAssay,ELISA)法检测血清S100B蛋白浓度,采用分光光度法检测MDA浓度和TOC。分析生化指标、疾病的精神病理症状、疗效间的关系。结果(1)人口学资料:疾病组共纳入首发未服药精神分裂症患者61例(男32例,女29例),年龄(27.3±7.7)岁,发病年龄(24.6±6.2)岁,总病程(48.9±56.5)月;对照组66例(男34例,女32例),年龄(27.4±5.5)岁。2组性别比、年龄无显著差异(P>0.05)。(2)疾病组与对照组S100B、TOC、MDA比较及治疗前后变化:疾病组S100B、TOC显著高于对照组,MDA浓度显著低于对照组(P<0.05);经8周治疗患者血清S100B、TOC、MDA均显著下降,其中MDA下降最为明显(见表1)。(3)利培酮疗效:经8周治疗,患者精神病性症状显著改善,将减分率≥50%定义为显著改善,>30为有效,治疗8周的有效率为88.5%,显著改善率为62.3%,第8周利培酮的治疗剂量为(4.30±1.24)mg/d。(4)基线血清S100B、TOC、MDA间及与精神病理症状的关系:相关分析结果提示,S100B浓度与TOC、MDA、病程、PANSS阴性症状分、PANSS总分显著相关,TOC与S100B浓度、PANSS阴性症状分、PANSS总分显著相关。S100B与机体抗氧化系统可能存在某种协同作用,共同影响精神分裂症患者精神病症状。(5)血清S100B、TOC、MDA对疗效的影响:S100B浓度与PANSS减分率显著负相关,TOC与减分率相关趋于显著水平(P=0.055);此外,病程与PANSS减分率显著负相关(见表2)。结论首发精神分裂症患者S100B与机体抗氧化体系可能存在交互作用,共同影响疾病症状和抗精神病药物对患者的治疗反应。

关键词：利培酮精神分裂症患者 MDA S100B TOC

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托莫西汀改善成年注意缺陷-多动障碍(ADHD)患者的健康相关生活质量和执行功能:一项针对亚洲人群为期

托莫西汀改善成年注意缺陷-多动障碍(ADHD)患者的健康相关生活质...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Yuko Hirata Taro Goto Yasushi Takita Paula T Trzepacz Albert J Allen Dong-Ho Song Susan Shur-Fen Gau Hironobu Ichikawa Michihiro Takahashi Sheng Hu Wu Lilly Research Laboratories Japan Eli Lilly Japan K.K.Kobe Japan Eli Lilly and Company IndianapolisUSA Severance Hospital Yonsei University SeoulKorea National Taiwan University Hospital & College of Medicine TaipeiTaiwan

研究目的该双盲、安慰剂对照临床试验通过评估患者的健康相关生活质量以及执行功能,研究托莫西汀治疗亚洲人群ADHD患者的疗效以及安全性。研究方法本临床研究经伦理委员会批准分别在日本、韩国和台湾开展。研究采用Corner's成人ADH... 详细信息

研究目的该双盲、安慰剂对照临床试验通过评估患者的健康相关生活质量以及执行功能,研究托莫西汀治疗亚洲人群ADHD患者的疗效以及安全性。研究方法本临床研究经伦理委员会批准分别在日本、韩国和台湾开展。研究采用Corner's成人ADHD诊断性访谈(Conners' Adult ADHD Diagnostic Interview for DSM-Ⅳ,CAADID)对ADHD患者进行诊断。入组患者均签署知情同意书,并被随机分配至托莫西汀组或安慰剂组接受为期10周的相应治疗。托莫西汀的治疗起始剂量为40mg/日,然后逐渐滴定至最高为120mg/日的剂量水平。患者的健康相关生活质量的测量采用成人ADHD生活质量量表(Adult Attention-Deficit/Hyperactivity Disorder Quality of Life,AAQoL),而执行功能的

关键词：托莫西汀注意缺陷多动障碍健康相关生活质量亚洲人群

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缓解期精神分裂症心理年龄滞后及相关因素分析

缓解期精神分裂症心理年龄滞后及相关因素分析

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

目的通过对缓解期精神分裂症心理年龄的评定从社会心理因素了解缓解期精神分裂症心理年龄滞后现象,分析其与应对方式、防御方式的相关性。方法采用自编心理年龄评估问卷(该问卷根据埃里克森的心理发展观对不同年龄发展阶段的发展任务的... 详细信息

目的通过对缓解期精神分裂症心理年龄的评定从社会心理因素了解缓解期精神分裂症心理年龄滞后现象,分析其与应对方式、防御方式的相关性。方法采用自编心理年龄评估问卷(该问卷根据埃里克森的心理发展观对不同年龄发展阶段的发展任务的描述改编而成)、应付方式问卷及防御方式问卷(DSQ),对来源于2012年9月至2012年11月在河北省第六人民医院就诊的171例缓解期精神分裂症患者进行评估。结果:171例精神分裂症患者通过心理年龄评定,医生评定心理年龄为11.08±3.52岁,与实际年龄比较差异有统计学意义(t=28.972,P<0.001);患者自评心理年龄为31.77±11.59岁,与实际年龄比较差异有统计学意义(t=2.667,P=0.008);照料者评定心理年龄为21.13±10.94岁,与实际年龄比较差异有统计学意义(t=17.269,P<0.001)。通过与实际

关键词：缓解期精神分裂症实际年龄河北省第六人民医院精神分裂症患者心理年龄防御方式问卷相关因素分析

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Effective connectivity of core emotional brain areas under positive and negative stimulus

Effective connectivity of core emotional brain areas under p...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Bi Kun Liu Chu Yao Zhi-jian Lu Qing Research Center of Learning Science Southeast University Academic Department of Psychiatry Nanjing Brain HospitalNanjing Medical University

PurposeSome findings showed that subcortical areas,such as amygdala on the expression of emotional behavior,play an important role in cognitive processing emotions. However,the prefrontal cortex and anterior cingulate cortex are the critical areas of regulating emotional state and expressing emotional *** addition,compared with the healthy controls,depressive patients are more sensitive to negative *** the contrary,it is insensitive to the positive *** this paper,the amygdala,anterior cingulate cortex and dorsolateral prefrontal cortex were selected as interested *** explored the difference of effective connectivity between depressive patients and healthy controls under positive and negative stimulation. Method Magnetoencephalography data from the CTF275 head type MEG system were acquired,sampling at a rate of 1200 *** were 24 depressive patients and 24 cases matched healthy *** amygdala,dorsolateral prefrontal cortex and anterior cingulate cortex were selected as interested *** preprocessing and source reconstruction of magnetoencephalography signal were undertaken via *** MEG recordings under neutral, sad and happy stimuli were chosed for *** under the neutral stimuli were taken as the *** granger causality model was applied to calculate the effective connectivity under positive stimulation and negative stimulation *** permutation test was used to compare differences between groups. Results Compared with healthy controls,the effective connectivity between the amygdala and the dorsolateral prefrontal cortex under negative stimulation decreased significantly in the ***,the effective connectivity from the dorsolateral prefrontal cortex to the amygdala increased significantly under positive *** significant difference was found in the connectivity of other regional pairs. Conclusion Depression patients are more sensitive to negative stimulus,and easier

关键词： Effective connectivity of core emotional brain areas under positive and negative stimulus

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One-year rehospitalization rates in patients with first-episode bipolar mania on lithium and valproate with adjunctive atypical antipsychotics

One-year rehospitalization rates in patients with first-epis...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Young Sup Woo Won-Myong Bahk Jong-Hyun Jeong Jong-Hyuk Choi Department of Psychiatry Chuncheon National hospitalChuncheonKorea Department of Psychiatry College of MedicineThe Catholic University of KoreaSeoulKorea

Objective:We compared the one-year rehospitalization rates of first-episode bipolar manic patients who were discharged while being treated with lithium or valproate in combination with an atypical antipsychotic. Methods We investigated the rehospitalization status of the first-episode bipolar manic patients who were discharged between January 1,2003 and December 31,2010 while they were taking lithium or valproate in combination with aripiprazole,olanzapine,quetiapine or risperidone. Rehospitalizations over a 1-year period after discharge were compared between the lithium plus an atypical antipsychotic group and valproate plus an atypical antipsychotic group,using the Kaplan-Meier *** regression model was used to analyze covariates thought to affect time to rehospitalization. Results The rehospitalization rate was 17.3%during the 1-year follow-up *** was significant differences in rehospitalization estimated using the Kaplan-Meier formula among the patients in the lithium group(23.1%) and valproate group(13.3%).By Cox proportional hazards regression analysis,lower Global Assessment of Functioning(GAP) score at discharge(p = 0.018) and lithium treatment(p = 0.034) contributed to the risk of rehospitalization. Conclusions Valproate treatment with an atypical antipsychotic significantly reduced risk of rehospitalization during the 1 year after discharge from hospitalization due to the first onset manic episode in bipolar I *** GAF score at discharge also negatively affected the rehospitalization rate.

关键词： One-year rehospitalization rates in patients with first-episode bipolar mania on lithium and valproate with adjunctive atypical antipsychotics

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Association between sleep and mild cognitive impairment in elderly people Running title:Effects of sleep on cognitive function

Association between sleep and mild cognitive impairment in e...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Cuixia An Lulu Yu Minwei Wang Xueyi Wang The Mental Health Institute of Hebei Medical University

Objective To compare the sleep quality between patients with mild cognitive impairment(MCI) and normal elderly,and analyze the effects of sleep on cognitive function. Methods 320 cases of MCI patients(MCI group) and 630 normal elderly with matched age, gender and years of education(control group) were enrolled in this *** sleep quality index(PSQI) was used to assess the sleep ***-mental state examination(MMSE) and Montreal Cognitive Assessment(MoCA) were used to assess the cognitive function. Results There were 110(34.3%) and 170(27%) cases with sleep disorders in MCI group and control group,respectively(P<0.01).There was significant difference of total PQSI scores between two groups,and the scores of sleep duration(factorⅢ) and habitual sleep efficiency (factorⅣ) in MCI group were significantly lower than control group,*** PQSI scores were negatively correlated with MoCA scores and MMSE scores,*** scores were negatively correlated with scores of sleep latency(factorⅡ),sleep duration(factorⅢ),habitual sleep efficiency(factorⅣ),respectively,and MMSE scores were negatively correlated with scores of factorⅢand factorⅣ,*** scores of attention and calculation,reading and language understanding,and visuospatial function(MMSE),and visuospatial and executive function,attention and clock drawing test(MoCA) in MCI patients without sleep disorders were significantly higher than those in MCI patients with sleep disorders, respectively. Conclusion The incidence of sleep disorders is higher in patients with MCI,compared with normal *** of sleep on cognitive function are mainly reflected in attention,and visuospatial and executive function.

关键词： Association between sleep and mild cognitive impairment in elderly people Running title:Effects of sleep on cognitive function

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Critical period of inhibitory effect of methylphenidate on hyperactivity in dopamine transporter knockout mice

Critical period of inhibitory effect of methylphenidate on h...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Yukio Takamatsu Yumiko Kubo Sarah Yukie Nagasawa George R.Uhl Ichiro Sora Kazutaka Ikeda Department of Developmental Medical Sciences Graduate School of MedicineThe University of Tokyo Department of Psychiatry Kobe University Graduate School of Medicine

Objective Attention-deficit/hyperactivity disorder(AD/HD),characterized by symptoms of inattention and hyperactivity-impulsivity,is a common neurodevelopmental disorder of childhood that often persists into adult *** dopamine transporter(DAT) knockout(KO) mice show hyperactivity which can be treated with methylphenidate,DAT-KO mice are considered model mice for AD/***,there have been few studies that focused on postnatal development of DAT-KO *** investigated association between postnatal development and methylphenidate induced inhibition of hyperactivity in DAT-KO mice. Methods Wildtype and DAT-KO mouse littermates from crosses of heterozygous/heterozygous DAT-KO ***-KO mice at 2,4,8,12,16,20 weeks were used to investigate the impact of the deletion of DAT on activity in the open-field,and then treated with methylphenidate(60 mg/kg) at 4,8 and 12 weeks. Results DAT-KO mice already exhibited hyperactivity at 2 *** inhibited hyperactivity in DAT-KO mice at 12 weeks,but not at 4 and 8 weeks. Conclusion These results suggest that there is a critical period for methylphenidate induced inhibition of hyperactivity in DAT-KO *** ineffectiveness of methylphenidate in developing DAT-KO mice may be related to insufficient evidence for methylphenidate effects on AD/HD patients before 7 years old.

关键词： Critical period of inhibitory effect of methylphenidate on hyperactivity in dopamine transporter knockout mice

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Determinants of suicidal ideation in patients with breast cancer

Determinants of suicidal ideation in patients with breast ca...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Jin-Sang Yoon Young-Woo Park Jae-Min Kim Ji-Eun Jang Department of Psychiatry Chonnam National University Medical Schooland Depression Clinical Research CenterChonnam National University HospitalGwangjuKorea

Background Breast cancer survivors are at higher risk of psychological problems including suicidal ***,studies on suicidal ideation in breast cancer survivors have been rare and have not been investigated *** study aimed to investigate the prevalence and independent risk factors for suicidal ideation within one week and at one year after breast surgery for breast cancer. Methods A total of 284 patients with breast cancer were evaluated within 1 week after breast surgery,and 244(84%) were followed one year *** ideation was ascertained using the item "suicidal thoughts" from the Beck Depression *** Factors potentially related to suicidal ideation were evaluated including sociodemographic and clinical characteristics,and genetic polymorphisms on serotonin and brain derived neurotrophic factor(BDNF) systems. Results Suicidal ideation was present in 10.9%of participants at 1 week and 11.4%at 1 year after breast *** ideation was independently associated with depression and physical disability at 1 week;and with living alone,anxiety,advanced cancer stage,and the BDNF met allele(but not with genetic polymorphisms on serotonergic system) at 1 year after breast surgery. Conclusion Suicidal ideation was common and had similar prevalences in both short and longer-term follow-up after breast ***,associated factors were substantially different between the two evaluation points which suggest that time-specific programs may be needed for identifying and managing suicidal risk in patients with breast cancer.

关键词： Determinants of suicidal ideation in patients with breast cancer

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The Effects of Smoking Cessation on Gene Expression

The Effects of Smoking Cessation on Gene Expression

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Dai-Jin Kim The Catholic University

Background:Cigarette smoking affects the prevalence of many diseases such as lung cancer and cardiovascular *** of chemical compositions are responsible for these diseases-related symptoms,including immune response,but the associated molecular alterations caused by smoking were not fully ***,we monitored and compared the gene expression of heavy smokers who succeeded or failed in smoking cessation. Methods We gathered 12 male nicotine dependent patients and they were asked to carry out 2 months of smoking *** a result,6 of them achieved abstinence(success group) and the rest of them failed(failure group).Their gene expression profiling was performed using a microarray of 30,398 features,then real-time PCR was conducted for selected genes;HEPACAM family member 2(HEPACAM2),tropomodulin 1(TMOD1),ubiquitin specific peptidase 18 (USP18) and interferon-induced protein 44(IFI44). Results Among 30,398 features,229 features were differently expressed between the two groups of ***,HEPACAM2(p = 0.024) and TMOD1(p <0.001) genes were more expressed,and USP18(p = 0.033) expression was lower in the success ***,the expression of IFI44 in the success group was not significantly distinguished from that of IFI44 in the failure group. Discussion Through smoking cessation,the variety of genes expression could change such as immunity,cytoskeleton,cell adhesion,cell proliferation and cancer-related ***,the elevation of HEPACAM2 and TMOD1 expression,and the decrease of USP18 expression after cessation might be connected with the decline in the risk of cigarette smoking-associated cancers. It is critical that the smoking cessation was succeeded not by medication but by ***, perhaps the resulting genes would be the biomarkers to support smoking-associated diseases and could explain related mechanisms that are caused by tobacco smoking.

关键词： The Effects of Smoking Cessation on Gene Expression

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