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The Global Efficiency in Structural Cortical Networks of Schizophrenia

The Global Efficiency in Structural Cortical Networks of Sch...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： CHEN Jian-Huai YAO Zhi-jian QIN Jiao-Long LU Qing Academic Department of Psychiatry Nanjing Brain HospitalNanjing Medical University Research Center of Learning Science Southeast University

Objective Efficiency as a network measure was first introduced to express the capacity of networks to facilitate information *** efficiency with which two nodes communicate was defined to be inversely proportional to the shortest distance between these *** global efficiency of the network is the average of the efficiency over all pairs and the global efficiency is related to the path ***,DTI tractography and graph theoretical approaches were used to compare the differences of the global efficiency of the nodes in the brain structural networks of the schizophrenia and the healthy. Method This study included 26 schizophrenia patients and 30 age- and gender-matched healthy *** participants were scanned with a 3-Tesla Siemens verio scanner with a 8-channel radio frequency coil MRI scanner in the Nanjing Brain *** tensor imaging and deterministic tractography were used to map the structural cortical networks of the participants. To determine the nodes of brain networks,the automated anatomical labeling(AAL) template had been used to parcellate the whole cerebral cortex into 90 areas(45 regions in each hemisphere).And to define the network edges,a threshold value(Two regions were considered structurally connected at least 2 fibers with 2 end points were located in these 2 regions) was selected for the fiber *** theoretical methods were applied to investigate the differences of the global efficiency of the nodes in the brain structural networks of the schizophrenia and the healthy. Result Compared with the healthy controls,the global efficiency of the nodes in the networks of schizophrenia patients descent significantly in the left insula(p = 0.00025*,*indicates region survived critical FDR threshold for multiple comparisons),the left thalamus(p = 0.00044*),the left median cingulate and the paracingulate gyri(p = 0.00051*),the left precuneus(p = 0.018), the left paracentral lobule(p = 0.018),the left supramarginal gy

关键词： The Global Efficiency in Structural Cortical Networks of Schizophrenia

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The Betweenness Centrality of White Matter Structural Networks in Schizophrenia

The Betweenness Centrality of White Matter Structural Networ...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Jiaolong Qin Jianhuai Chen Rui Yan Hao Tang Zhijian Yao Qing Lu Research Center of Learning Science Southeast University Academic Department of Psychiatry Nanjing Brain HospitalNanjing Medical University

Objective The betweenness centrality as a measure was first introduced to evaluate the role or the position of nodes in the *** measures the probability of a node that appear in the shortest path between other nodes and it indicates the ability of the node as an information hub in the entire ***,we used DTI tractography and graph theoretical approaches to compare the differences of the betweenness centrality of the nodes in the brain structural networks of the schizophrenia and the healthy. Methods This study included 26 schizophrenia patients and 34 age- and gender-matched healthy *** participants were scanned with a 3.0-Tesla Siemens verio scanner with an 8-channel radio frequency coil MRI scanner in the Nanjing Brain *** used diffusion tensor imaging and deterministic tractography to map the structural networks of the participants. To determine the nodes of brain networks,we used the automated anatomical labeling（AAL） template to parcellate the whole cerebral cortex into 90 areas（45 regions in each hemisphere）. Graph theoretical methods were applied to investigate the differences of the betweenness centrality of the nodes in the brain structural networks of the schizophrenia and the healthy. Results Compared with the healthy controls,the betweenness centrality of the network nodes in schizophrenia decreased significantly in the left middle temporal gyrus（p0.00038,*indicates region survived critical FDR threshold for multiple comparisons）,left median cingulate and paracingulate gyri（p = 0.023）,left caudate nucleus（p = 0.035） and increased significantly in the right gyrus rectus（p = 0.013）,left superior temporal gyrus（temporal pole）(p = 0.037),right insula（p = 0.00107*）. Conclusion Our findings suggest that changes of the betweenness centrality of the structural networks nodes in the schizophrenia are mainly distributed in areas of frontal and temporal lobes and in the limbic *** findings demonstrate that the ability of som

关键词： The Betweenness Centrality of White Matter Structural Networks in Schizophrenia

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Survey of rights and interests in psychiatric inpatients in Guangzhou city

Survey of rights and interests in psychiatric inpatients in ...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Su jinghua Guangzhou psychiatric hospital

Aims The Mental Health Law of China was adopted by the National People's Congress on October 26,2012 and will be enforced after May 1,*** aim of this study was to investigate the protection of rights and interest in psychiatric inpatients before the enforcement of Mental Health Law in Guangzhou city. Methods From October 2012 to November 2012,five hospitals(3 psychiatric special hospitals, 2 general hospitals,have 2138 beds) were randomly(multistage cluster sampling) selected from 15 hospitals(9 psychiatric special hospitals,6 general hospital,have 5767 beds) which provide psychiatric inpatient care in *** these hospitals,we collected information about rights and interests of psychiatric inpatients through a self-designed *** about admission and discharging process,execute of informed consent,communication rights and privacy protection were *** were entered through EPIDATA 3.1 and analyzed by SPSS 20.0. Result Among 1046 psychiatric inpatients who were selected to surveyed,there were 59 of them refused to participate in the study and 135 of them unable to complete the questionnaire because of serious ***,there were 852 psychiatric inpatients completed the study (schizophrenia 568,affective disorder 195,other diagnosis 89).There were 90.5%(759/839) of patients reported that the informed consent were signed by others,only 21.6%(183/848) of patients reported to have been explained about the informed consent by the medical staff;Visit is allowable for 97%(821/846) of inpatients,however only 36.9%(313/846) of patients can claim to contact with outside,among these patients,only 49.5%(155/313) of them can use fixed phone provided by the hospital and only 39%(123/313) of them can keep their own mobile phone. Around 60%(495/843) patients have bath in public *** 10%(84/848) of patients can decide when to discharge from *** general,compare with patients with affective disorder, patients with schizop

关键词： Survey of rights and interests in psychiatric inpatients in Guangzhou city

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The abnormal effective connections of prefrontal-amygdala during major depressive patients recognizing happy face

The abnormal effective connections of prefrontal-amygdala du...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Hua Ling-ling Li Hao-ran Tang Hao Lu Qing Yao Zhi-jian Nanjing University Southeast University Academic Department of Psychiatry Nanjing Brain HospitalNanjing Medical University

Objective To explore the abnormal effective connections of prefrontal-amygdala in patients with major depressive disorders when they recognized dynamic positive face expressions with the technology of magnetoencephalograph(MEG),and discuss the possible mechanism of abnormal effective connections in patients. Methods 20 major depressive patients and 20 matched healthy volunteer controls underwent MEG scanning when they recognized the dynamic facial emotion videos,then utilizing SPM8 software to process the original magnetic *** regions of interested brain area included the primary visual cortex(V1),the precuneus(PQ),the dorsolateral frontal cortex(DLPFC),the anterior cingulated cortex(ACC),the amygdala(AMYG).After constructing three putative models,using dynamic causal model to select an optimal model,then extracted all the effective connection parameters and t-test under the overall optimal model 2 between groups,finally to analysis the differences of the effective connections of the optimal *** parameter of model mainly included that time window was 0-800ms,neutral face as baseline and happy face as deviant,spatial model was equivalent current dipole(ECD). Result The bayesian model selection(BMS) indicated that model 2 was the most superior model,Whose exceedance probability was *** the right hemisphere of patients group,the endogenous connectivity from AMYG to ACC significantly decreased relative to healthy controls(t = -2.21,p = 0.03),while the endogenous connectivity from ACC to DLPFC was enhanced significantly(t = 2.50,p = 0.017),which was the same with the endogenous connectivity from AMYG to DLPFC(t = 2.10,p = 0.04 ). Conclusions The effective connections of prefrontal-amygdala in major depressive disorder are exactly impaired,which indicate that major depressive disorder have a bias toward negative.

关键词： The abnormal effective connections of prefrontal-amygdala during major depressive patients recognizing happy face

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The association of insight with clinical symptoms in depressive patients

The association of insight with clinical symptoms in depress...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Qing Chang Yufen Ou Li Liang Yuanfei Wu Yuwei Chen Yuping Ning Hongbo He The association of insight with clinical symptoms in depressive patients

Objective It is known that insight in patients with major depressive disorder(MDD) and bipolar disorder(BP) was comparatively intact during recovery stages,and was partially impaired during the acute depressive phase of the *** this study,we recruited depressive inpatients in a large psychiatric hospital in south China to examine the relationship between insight and clinical depressive symptoms. Methods Depressive inpatients with MDD or BD based on ICD-10 diagnostic criteria were *** informed consent was signed after *** socio-demographic data were collected from medical *** symptoms were measured by Hamilton Depression Rating Scale for Depression(HAMD-17) and Symptom check list-90(SCL-90).Insight was assessed by the Insight and Treatment Attitudes Questionnaire(ITAQ).HAMD-17 and SCL-90 were assessed both in a week after admission and a week before discharge,and ITAQ was only evaluated a week before *** clinical features like length of stay(LOS),duration of illness,duration of untreated psychosis(DUP),previous episodes of depression and the previous admissions for depression was recorded during interview with patients and their families. Descriptive statistics were computed for socio-demographic and clinical *** correlations were calculated for the overall insight scores measured with ITAQ and the clinical symptoms assessed with *** rank-ordered test was used for the data that were not normally *** analyses were performed by using SPSS,Version 17.0. Results Total of 140 participants completed this study,with 85(60.7%) BD and 55(39.3%) MDD respectively,mean age 32.5±11.9 years *** total ITAQ scores was 14.0±5.9,and mean scores for subscale of awareness of illness and awareness of medication were 6.5±2.8 and 7.4±3.3 *** total scores of HAMD-17 for admission and discharge were 23.2±16.4 and 9.1±7.4 respectively. Bivariate correlation analyses show

关键词： The association of insight with clinical symptoms in depressive patients

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COCAINE SENSITIZATION REQIRES RAPHE SEROTONERGIC NEURONS ACTIVITY;A STUDY USING DESIGNER RECEPTORS EXCLUSIVELY ACTIVATED DESIGNER DRUGS

COCAINE SENSITIZATION REQIRES RAPHE SEROTONERGIC NEURONS ACT...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Hidehiro Oshibuchi

Background Twin studies suggest that the establishment of substance use is strongly controlled by genetic *** short(s)/s genotype at the serotonin transporter gene linked polymorphic region had age-dependent effects on drug *** short variant reduces the transcriptional efficiency of the gene resulting in decreased serotonin transporter expression in the ***,expression of genetic vulnerability for substance use in children and adolescents may partly depend on interaction of serotonin *** serotonergic projections to dopaminergic pathways implicated in psychostimulant responses are believed to generally suppress their activity,studies examining serotonergic pharmacological manipulations on pyschostimulant actions have produced inconsistent *** this study,we examined the net effect of raphe serotonergic neurons on cocaine responses using mice expressing "designer receptors exclusively activated by designer drugs(DREADD)". Method G protein coupled receptors signaling pathways Gq(hM3Dq) or Gi(hM4Di) and green fluorescent gene(GFP) were transferred by bilateral raphe nucleus injections of Cre dependent adeno-associated virus into mice expressing Cre recombinase in serotonergic neurons. Three experimental groups(hM3Dq+GFP,hM4Di+GFP or GFP,n = 10 each) were respectively activated,silenced or unaffected by Clozapine-N-oxide in drinking *** activity (LA) was measured by photobeam breaks under three conditions novel environment,single dose of cocaine,and re-challenge of cocaine after cocaine-sensitization. Result Novel environment did not elicit differences in exploratory behavior among the three *** dose of cocaine 15 mg/kg stimulated LA in all animals(p = 0.001,One factorial ANOVA),without differences among *** cocaine re-challenge,hM3Dq and GFP groups showed significantly higher LA compared to that seen following a single dose(p = 0.017, 0.014 each,two-factorial ANOVA and Bonferroni's post hoc study).

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The Betweenness Centrality of White Matter Structural Networks in Depression

The Betweenness Centrality of White Matter Structural Networ...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Jiaolong Qin Jianhuai Chen Hao Tang Rui Yan Zhijian Yao Qing Lu Research Center of Learning Science Southeast University Academic Department of Psychiatry Nanjing Brain HospitalNanjing Medical University

Objective The betweenness centrality as a measure was first introduced to evaluate the role or the position of nodes in the *** measures the probability of a node that appear in the shortest path between other nodes and it indicates the ability of the node as an information hub in the entire ***,we used DTI tractography and graph theoretical approaches to compare the differences of the betweenness centrality of the nodes in the brain structural networks of the depression and the healthy. Methods This study included 27 depression patients and 33 age- and gender-matched healthy *** participants were scanned with a 3.0-Tesla Siemens verio scanner with an 8-channel radio frequency coil MRI scanner in the Nanjing Brain *** used diffusion tensor imaging and deterministic tractography to map the structural networks of the *** determine the nodes of brain networks,we used the automated anatomical labeling(AAL) template to parcellate the whole cerebral cortex into 90 areas(45 regions in each hemisphere). Graph theoretical methods were applied to investigate the differences of the betweenness centrality of the nodes in the brain structural networks of the depression and the healthy. Results Compared with the healthy controls,the betweenness centrality of the networks nodes in the depression decreased significantly in the right superior frontal gyrus(orbital part)(p = 0.00035*,*indicates region survived critical FDR threshold for multiple comparisons),left inferior frontal gyrus(triangular part)(p = 0.036),left middle temporal gyrus(temporal pole)(p = 0.022),right supramarginal gyrus(p = 0.041),left putamen(p = 0.00054*) and increased significantly in the right supplementary motor area(p = 0.021),right fusiform gyrus(p = 0.011), right postcentral gyrus(p = 0.013). Conclusion Our findings suggest that changes of the betweenness centrality of the structural network nodes in depression are mainly distributed in areas of frontal,tempora

关键词： The Betweenness Centrality of White Matter Structural Networks in Depression

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Differential regulation of haloperidol and olanzapine on JAK2/STAT3 pathway in rat prefrontal cortex

Differential regulation of haloperidol and olanzapine on JAK...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Chongsheng SONG Mei HAN HongQin WANG Xu-Feng HUANG Beijing Huilongguan Hospital University of Wollongong WollongongNSW2522Australia

Objective Cognitive deficits are a fundamental feature of the psychopathology of *** evidence supports atypical antipsychotic medications such as olanzapine can improve the neurocognitive *** the underlying mechanism is only partially *** has been reported that inactivation of the Janus kinase 2(JAK2)/ signal transducer and activators of transcription 3(STAT3)axis may cause memory loss through cholinergic *** study examined whether olanzapine affects the signalling path of JAK2/STAT3in the rat prefrontal cortex:exploring the possible pharmacological mechanism of olanzapine in improving neurocognitive function. Methods Female rats were treated with haloperidol(0.1mg/kg),olanzapine(1.0mg/kg) or saline for one time,three times/day for 3days or6 *** were then killed two hours later once they received the last *** blot was used to determine total and phosphorylated protein levels of JAK2andSTAT3 in the rat prefrontal *** statistical analysis was performed using SPSS19.0. Results After a single injection,haloperidol treatment significantly decreased expression levels inSTAT3 and p-STAT3in the prefrontal cortex(all p <0.05).At the three day time-point,the level of p-JAK2 of olanzapine was significantly higher than that of haloperidol(p <0.05) although olanzapine did not show significant effect compared to saline *** the six day time-point,compared to salines,olanzapine significantly increased the levels of p-JAK2 and P-STAT3(p <0.05). Conclusion The study suggests that olanzapine may partly improve cognitive function by regulatingJAK2/STAT3 pathway in the prefrontal ***,haloperidol may have a transient effect in this pathway.

关键词： JAK Differential regulation of haloperidol and olanzapine on JAK2/STAT3 pathway in rat prefrontal cortex

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Structural and functional connectivity of depression between the left amygdala and left dorsolateral prefrontal cortex under negative stimulus

Structural and functional connectivity of depression between...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Bi Kun Liu Chu Yao Zhi-jian Lu Qing Research Center of Learning Science Southeast University Academic Department of Psychiatry Nanjing Brain HospitalNanjing Medical University

Purpose The brain structure and function are closely linked together to reflect the status of the *** diffusion tensor imaging and magnetoencephalography,we explored the structural connectivity and effective connectivity between the left amygdala and the left dorsolateral prefrontal cortex,considering the left hemisphere partial lateralization in depression. Method Seventeen patients and 17 matched healthy controls were included.T1 weighted images and diffusion weighted images were collected using Siemens Verio 3T magnetic resonance *** was utilized for data *** fiber probability tracking algorithm was used to calculate the number of fiber bundles from the interested area to the whole *** test was used to compare differences between *** the calculation of effective connectivity,MEG signals under sad stimuli were *** data preprocessing and sources reconstruction of signals were undertaken using *** dimension reduction of signals was carried out using *** causality model was designed for effective connectivity *** test was used to compare differences between groups. Result The structural and effective connectivity between two groups were all found to be significantly *** with healthy controls,the structural connectivity between the left dorsolateral prefrontal and the left amygdala decreased significantly in *** effective connectivity from the left amygdala to the left dorsolateral prefrontal cortex decreased significantly,while no significances were found in the effective connectivity from the left dorsolateral prefrontal to the left amygdala. Conclusion The deactivation of left dorsolateral prefrontal cortex caused the information transmission from the left amygdala to this area decreased *** of depression is highly sensitive to negtive emotion,and the compromise between emotional processing and cognitive control in dorsolateral

关键词： Structural and functional connectivity of depression between the left amygdala and left dorsolateral prefrontal cortex under negative stimulus

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The Betweenness Centrality of Nodes in Weighted Structural Cortical Networks in Schizophrenic patients

The Betweenness Centrality of Nodes in Weighted Structural C...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： CHEN Jian-Huai YAO Zhi-jian QIN Jiao-Long LU Qing Academic Department of Psychiatry Nanjing Brain HospitalNanjing Medical University Research Center of Learning Science Southeast University

Objective The betweenness centrality of an individual node is defined as the fraction of all shortest paths in the network that pass through the node.A node with high betweenness centrality can control information flow because it is at the intersection of many short *** centrality characterizes the influence or centrality of a node from the viewpoint of the flow or dynamic process occurring on the *** identification of highly influential nodes on the basis of graph topology represents a step toward the classification of network elements in terms of their potential functional ***,DTI tractography and graph theoretical approaches were used to compare the differences of the betweenness centrality of the nodes in the brain weighted white matter(WM) networks of the schizophrenia and the healthy. Method This study included 26 schizophrenia patients and 29 age- and gender-matched healthy controls were *** participants were scanned with a 3-Tesla scanner with a 8-channel radio frequency coil MRI scanner in the Nanjing Brain *** tensor imaging and deterministic tractography were used to map the weighted cortical networks of the participants. To determine the nodes of brain networks,the automated anatomical labeling(AAL) template was used to parcellate the whole cerebral cortex into 90 areas(45 regions in each hemisphere). And to define the network edges,a threshold value(Two regions were considered structurally connected at least 2 fibers with 2 end points were located in these 2 regions) was selected for the fiber *** the weighted white matter(WM) networks were constructed with FA(The FA value is an important index to evaluate fiber integrity and has a high correlation with conductivity) as the weight of each *** theoretical methods were applied to investigate the differences of the betweenness centrality of the nodes in the brain weighted WM networks of the schizophrenia and the healthy. Result When compa

关键词： The Betweenness Centrality of Nodes in Weighted Structural Cortical Networks in Schizophrenic patients

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