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Perceived Stress,Coping Strategy and Psychopathology Among HIV Seropositive People who Injecting Drug(PWID) in Working Group on AIDS Cipto Mangunkusumo Hospital,Scientific Light Foundation on HIV,Tebet Primary Health Center and Kios Atmajaya University Jak

Perceived Stress,Coping Strategy and Psychopathology Among H...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Khamelia Malik Nurmiati Amir Suryo Dharmono Department of Psychiatry Faculty of MedicineUniversity of Indonesia

Introduction Indonesia with population of 237.5 million has been estimated HIV prevalence of 0.27%among the 15-49 years age ***'s HIV and AIDS epidemic is concentrated amongst key affected population resulting from a mix of two modes of transmission and drug *** cumulative report HIV cases shows infection from injecting use is 36%. Further analysis shows that the proportion of People Who Inject Drugs(PWID) who infected in their first year of engagement is high overtime(2007 and 2011) at 27%and 13%.Percentage of PWID that have received an HIV test in the last 12 months and who know their result is 90.6%. Only 67%percentage of adult with HIV known to be on treatment 12 months after initiation of ARV *** are those who are lost to follow up(18.6%),have stopped treatment(0.4%) or die(2.7%) Good care needs to be used in interpreting patient's reasons for not taking or continuing ART. Some issues identified,like geographical distance,high cost association like *** local studies about internal or psychological issue is limited. This study aims to contribute knowledge of how coping mechanism and psychopathology among HIV positive *** scientific understanding as to the function and effect of coping mechanism could lead to enhance relevant approaches in service delivery among HIV positive PWID *** this knowledge could inform research about specific behavior that needs to be targeted in treatment programs with this population. Subject and methods The participants for this study were 100 HIV seropositive PWID adult men and women from Working Group on AIDS Cipto Mangunkusumo Hospital,Scientific Light Foundation on HIV,Tebet Primary Health Center and Kios Atmajaya from July 2010 until December *** used Perceived Stress,Coping Orientation to the Problem Experienced (COPE) Inventory and Symptom Check List-90(SCL-90) to assess the variables in this cross-sectional *** data were obtained from medical

关键词： HIV Perceived Stress,Coping Strategy and Psychopathology Among HIV Seropositive People who Injecting Drug in Working Group on AIDS Cipto Mangunkusumo Hospital,Scientific Light Foundation on HIV,Tebet Primary Health Center and Kios Atmajaya University Jak

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Effects of Antipsychotic Drugs on the Expression of Synaptic-associated Proteins in the Frontal Cortex of Rats Subjected to Immobilization Stress

Effects of Antipsychotic Drugs on the Expression of Synaptic...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Chan Hong Lee Mi kyoung Seo Hye Yeon Jo Cheol Min Choi Jung Goo Lee Bong Ju Lee Sung Woo Park Young Hoon Kim Paik Institute for Clinical Research Inje UniversityBusanRepublic of Korea Neuroscience Health Science & TechnologyInje UniversityBusanRepublic of Korea. Paik Institute for Clinical Research Inje UniversityBusanRepublic of Korea Department of Psychiatry School of MedicineHaeundae Paik HospitalInje UniversityBusanRepublic of Korea Neuroscience Health Science ＆ TechnologyInje UniversityBusanRepublic of Korea.

Objectives Several postmortem studies have noted decreased expression of genes responsible for synaptic proteins in the prefrontal cortex(PFC) and other regions,suggesting impairment or reduction in synaptic connectivity in ***,antipsychotic drugs have been suggested to regulate synaptic transmission and *** this study,we investigate the effects of typical antipsychotic drug,haloperidol and atypical antipsychotic drugs olanzapine and aripiprazole,on the expression of synaptic-associated proteins in the frontal cortex of rats subjected to immobilization stress. Methods SD rats were subjected to immobilization stress 6 h/day for 3 *** effect of olanzapine(2 mg/kg),aripiprazole(1.5 mg/kg) or haloperidol(1.0 mg/kg) on the expression of brain-derived neurotrophic factor(BDNF),phosphor-serine9- glycogen synthase kinase-3p (GSK-3P) and P-catenin,and synaptic proteins including synaptic proteins including postsynaptic density protein-95(PSD-95),neurolignin 1(NLG1),P-neurexin,and synaptophysin(SYP) in frontal cortex of rat subjected to immobilization stress. Results Immobilization stress significantly decreased the expression of these proteins in frontal cortex(p< 0.01).Olanzapine and aripiprazole completely reversed the immobilization stress-induced decrease in BDNF,phosphorylated GSK-3p,PSD-95,NLG1 and SYP(p< 0.05 or p< 0.01) expression *** did not affect p-catenin and P-neurexin(p< 0.01) levels under stress ***,olanzapine and aripiprazole significantly increased the levels of phosphorylated GSK-3p and NLG1(p< 0.05 or p < 0.01),respectively,even under normal conditions,whereas aripiprazole increased the levels of BDNF and p-neurexin(p< 0.01).In contrast,haloperidol had no effect on the levels of these proteins in frontal cortex of rats with or without immobilization stress. Conclusions Taken together,these results suggest that olanzapine and aripiprazole might exert their beneficial effects through up-regulati

关键词： Cortex Effects of Antipsychotic Drugs on the Expression of Synaptic-associated Proteins in the Frontal Cortex of Rats Subjected to Immobilization Stress

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Sertraline and periodic limb movement during sleep:an 8-week,open-label study in depressed patients with insomnia

Sertraline and periodic limb movement during sleep:an 8-week...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Bin Zhang Yanli Hao Fujun Jia Xueli Li Guangdong General Hospital Guangdong Academy of Medical SciencesGuangdong Mental Health Centre Department of Human Anatomy Guang Zhou Medical University

Background Previous studies have reported that selective serotonin reuptake inhibitors(SSRIs) might induce or exacerbate periodic limb movement during sleep(PLMS). However,most of them were retrospective and cross-sectional studies with small sample size on a selective SSRI,*** different SSRIs have different pharmacological profiles,it was not certain whether other SSRIs might also lead to PLMS. Methods Data were taken from an open-label 8-week trial of sertraline in depressive patients with insomnia(n=31).Depressed patients were administered 50 mg sertraline at 8 am on the 1st day,and the dosage was subsequently titrated up to a maximum of 200 mg/day during the 8-week *** patients were tested by repeated polysomnography(PSG)(baseline,1st day,14th day, 28th day,and 56th day).Periodic leg movements were visually counted and the PLM index (PLMI) was *** was defined as PLM≥5,and significant PLMS was defined as PLM≥15. Results Compared with baseline(PLMI=3.6±1.5),all PLMI indices increased upon the immediate administration of sertraline on the 1st day(PLM=5.1±3.9).From the 14th day onward, PLMI became stable and significantly higher than baseline and the 1st day(8.7±3.1 on the 14th day,8.3±3.7 on the 28th day,8.5±3.6 on the 56th day,F=11.81,P = 0.003).The clinical responses and PSG characteristics improved continuously during the 8-week *** PLMS group(PLM>5) had more arousal index(AI) than Non-PLMS group on the 14th day index (9.4±5.5 versus 5.2±3.7,T=4.22,P = 0.03) and the 56th day(8.1±5.5 versus 4.3±3.7,Z=3.11,P = 0.04),albeit there was no significant clinical disturbances in the PLMS group. Conclusions PLMS was increased during sertraline treatment,but only a few of them reached the significant *** effect of sertraline on PLMS might be dosage *** the sertraline-induced PLMS seemed not to have significant clinical disturbance,the PLMS group (PLM≥5) has higher AI than the non-PLMS ***,clinicians should pay

关键词： Sertraline and periodic limb movement during sleep:an 8-week,open-label study in depressed patients with insomnia

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2013 CSP/AsCNP Individualized MDD Treatment Forum Sponsored by Eli Lilly Individualized MDD treatment and development(Draft)

2013 CSP/AsCNP Individualized MDD Treatment Forum Sponsored ...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

For MDD treatment,generally speaking,different therapeutics(medication vs psycho-therapy), different treatment protocols show similar efficacy for mild to moderate *** similar overall efficacy,individuals may respond to different treatments in greatly different *** that case,it is highly important to choose the right antidepressant treatment regimen as early as possible according to patients' symptoms. What is the individualized MDD treatment? How to choose the suitable individualized MDD

关键词： MDD CSP/AsCNP Individualized MDD Treatment Forum Sponsored by Eli Lilly Individualized MDD treatment and development Draft

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Pattern of Drug Use in Bipolar Disorder in Hong Kong

Pattern of Drug Use in Bipolar Disorder in Hong Kong

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Ming Cheuk Michael Wong MB BS(HK)MRCPsych(UK)FHKAMFHKCPsych

Bipolar affective disorder is a mood disorder with different presentation at different phase of the *** is no universally agreed protocol in the treatment of this *** there are different treatment guidelines and recommendations proposed by different professional organizations,e.g the CANMAT and WFSBP *** actual pattern of drug use may be different from place to *** study looks at the pattern of drug treatment in the treatment of this disorder in the outpatients in a psychiatric unit in a general hospital in Hong Kong.572 bipolar affective disorder patients attended the outpatient clinic in the year *** preliminary

关键词： SGA Pattern of Drug Use in Bipolar Disorder in Hong Kong

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Pharmacokinetic study of bitopertin,a glycine reuptake inhibitor,in Chinese healthy volunteers

Pharmacokinetic study of bitopertin,a glycine reuptake inhib...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： John(Suoping)Zhai Haiyan Li Alice Wang Meret Martin-Facklam Rose Luo Alice Wang Meret Martin-Facklam Rose Luo Pharmacogenetics/pharmakinetics

Background and Objective Bitopertin(RO4917838) is a glycine reuptake inhibitor that is postulated to improve N-methyl-D-aspartate-(NMDA) receptor hypofunction in the brain by increasing synaptic concentrations of *** leads to normalization of the dysregulated glutamate,GABA and dopamine in neurocircuits relevant to *** compound is currently in Phase 3 for the treatment of *** objective of the study was to assess the pharmacokinetics(PK),safety and tolerability in Chinese healthy volunteers(HVs),

关键词： AUC Pharmacokinetic study of bitopertin,a glycine reuptake inhibitor,in Chinese healthy volunteers

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Common use of high doses of antipsychotic medications in older Asian patients with schizophrenia(2001-2009)

Common use of high doses of antipsychotic medications in old...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Yu-Tao Xiang Department of Psychiatry Chinese University of Hong KongHong KongChina Beijing Anding Hospital Capital Medical UniversityBeijingChina

Background and Objective In the past several decades,the use of high antipsychotic doses has been a continuously controversial topic in both clinical practice and *** most of the studies and treatment recommendations do not support this practice,antipsychotic drugs are still widely prescribed in high doses in the treatment of *** example, 15.4%-41%of adult schizophrenia inpatients in the USA and in Europe receive high-dose *** could not locate any large-scale,pharmaco-epidemiological surveys on high antipsychotic doses in older patients with *** study aimed to examine the use of high doses of antipsychotic medications(>/=600 mg/day CPZeq) in older Asian patients with

关键词： Common use of high doses of antipsychotic medications in older Asian patients with schizophrenia

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Correlation of the serotonin transporter gene poly

Correlation of the serotonin transporter gene poly

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

OBJECTIVE We tested whether a polymorphism in the promoter region of the serotonin transporter correlated to episode,gender,severity,and suicidal behavior in depression in Chinese Han people. METHODS Polymerase chain reaction was used to detect promoter polymorphisms in 150 depressed patients(patient group) and 150 normal *** patients consisted of 74 males and 76 females,with an average age of 45.6±12.3 years and were diagnosed by experienced psychiatrists according to ICD-10 diagnosis criteria. RESULTS The frequency of5-HTTLPR genotypes SS,LS(26.0%vs 20.0%;52.7%vs 46.0%)

关键词： Correlation of the serotonin transporter gene poly

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Threat induced autonomic dysregulation in panic disorder evidenced by heart rate variability measures

Threat induced autonomic dysregulation in panic disorder evi...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Sheng-Min Wang Chung Tai Lee Jeong-Ho Chae Sheng-Min Wang Chung Tai Lee Jeong-Ho Chae Department of Psychiatry College of MedicineThe Catholic University of KoreaSeoulKorea

Background To compare autonomic response to threatening stimuli between patients with panic disorder(PD) and healthy volunteers by using 5-minute recordings of heart rate variability(HRV). Methods Twenty-seven patients with PD and twenty healthy controls were *** first 5-minute measurement of HRV was conducted at resting *** measure during threatening stimuli was conducted while participants were viewing 15 threatening *** analyses measures included high frequency(HF;0.15-0.4 HZ) component,low frequency(LF;0.04-0.15 Hz) component,and LF/HF ratio. Results There was no significant HRV difference between the two groups at the resting state. During threatening stimuli,PD group had significantly higher LF power and LF/HF ratio and significantly lower HF power than healthy controls(for all,p

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A 12-week randomized,double-blind,placebo-controlled multicenter clinical trial of acamprosate for the treatment of alcohol dependence

A 12-week randomized,double-blind,placebo-controlled multice...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： SUN Wei LI Bing XU Xiu-feng HUANG Ji-zhong TAN Qing-rong DENG He-huang LI Ke-qing GAO Jun-yu QIU Yu-jia Peking University Institute of Mental Health Key Laboratory of Ministry of Health(Peking University) First Affiliated Hospital of Kunming Medical University Shanghai Mental Health Center First Affiliated Hospital of Fourth Military Medical University Guangzhou Psychiatric Hospital The Mental Health Center of Hebei Province Affiliated Hospital of Academy of Military Medical Sciences

Objective To evaluate the efficacy and safety of acamprosate in treating patients with alcohol dependence. Methods A randomized,double-blind,placebo-controlled multicenter clinical trial was *** diagnosis of alcohol dependence was made according to the Diagnostic and Statistical Manual of Mental Disorders,Fourth Edition(DSM-IV) *** 230 patients received 12 weeks treatment with either acamprosate(weight<60 kg,1332 mg/d;weight>60 kg, 1998 mg/d.n=116) or placebo(n=l14).The primary efficacy measures were the cumulative abstinence duration(CAD) and corrected cumulative abstinence duration(CCAD),relapse rate of every visit,time to first *** secondary efficacy measures were the drinking times,the

关键词： A 12-week randomized,double-blind,placebo-controlled multicenter clinical trial of acamprosate for the treatment of alcohol dependence

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