Backgound Opioid abuse is a worldwide *** to opioid abuse is widely accepted to have a close relationship to theμopioid receptor gene spesifically to A 118G polymorphism which varied 2-50%among the nations and C 17T ...
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Backgound Opioid abuse is a worldwide *** to opioid abuse is widely accepted to have a close relationship to theμopioid receptor gene spesifically to A 118G polymorphism which varied 2-50%among the nations and C 17T *** Indonesia,study of A 118G and C 17T polymorphismsμopioid receptor gene had never been conducted. Objectives To see the distribution of A 118G and C 17 ofμopioid receptor gene
The 'Depression Executive Dysfunction Syndrome' afflicts a considerable number of depressed elderly patients and may be resistant to conventional *** studied the Choline Alfoscerate or the ethyl ester of eicos...
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The 'Depression Executive Dysfunction Syndrome' afflicts a considerable number of depressed elderly patients and may be resistant to conventional *** studied the Choline Alfoscerate or the ethyl ester of eicosapentaenoic acid(E-EPA) as an adjunct to antidepressant treatment for episodes of depressive disorder occurring in older depressed patients(over 60 years old) with or without executive dysfunction. The design was a 12-week,parallel-group,double-blind addition of Choline Alfoscerate or E-EPA to ongoing antidepressant *** continued their current antidepressant
Aversive memories associated with drug withdrawal may contribute to persistent drug seeking. Molecular mechanisms that are critical for aversive memory formation have yet to be elucidated. Recently,we showed in a rat ...
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Aversive memories associated with drug withdrawal may contribute to persistent drug seeking. Molecular mechanisms that are critical for aversive memory formation have yet to be elucidated. Recently,we showed in a rat conditioned place aversion(CPA) model that synaptic actin polymerization in the amygdala were required for aversive memory ***,we demonstrated that actin polymerization within the amygdala triggered transportation of activity-regulated cytoskeletal-associated protein(Arc/Arg3.1) into amygdalar synapses.
Current treatment for attention deficit hyperactivity disorder(ADHD) has limited efficacy for frequently comorbid oppositional defiant disorder(ODD).N-methyl-D-aspartate(NMDA) receptor activity,playing a vital role in...
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Current treatment for attention deficit hyperactivity disorder(ADHD) has limited efficacy for frequently comorbid oppositional defiant disorder(ODD).N-methyl-D-aspartate(NMDA) receptor activity,playing a vital role in mood modulation,can be a potential target of drug development for such *** study aims to assess the efficacy and safety of an endogenous glycine transporter-1(GlyT-1) inhibitor,sarcosine(N-methylglycine),for treatment of ADHD in *** hundred and sixteen children were enrolled in a 6-week,randomized,double-blind clinical trial to receive sarcosine(0.03 gm/kg/day) or *** primary outcome measures included inattention,hyperactivity/impulsivity,and oppositional defiant disorder(ODD) subscales of Swanson,Nolan,and Pelham,version IV scale(SNAP-IV-C).Sarcosine surpassed
Objective The development of long-acting injectable(LAI) antipsychotics aims to tackle the challenging issue of adherence in treatment of psychotic *** controlled trials, however,are likely to selectively recruit adhe...
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Objective The development of long-acting injectable(LAI) antipsychotics aims to tackle the challenging issue of adherence in treatment of psychotic *** controlled trials, however,are likely to selectively recruit adherent patients and could not differentiate the difference between LAI and oral forms of *** observational study with national database in Taiwan was to assess the economic effectiveness of risperidone long-acting injection (RLAI) in the real-world clinical practice. Method We analyzed the health service uses and costs in a cohort of schizophrenia from the
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