Lithium,a direct inhibitor of glycogen synthase kinase 3(GSK-3),has been widely prescribed mood stabilizer in treatment of bipolar *** suggests that lithium affects monocytic cells,which play pivotal roles in the inna...
Lithium,a direct inhibitor of glycogen synthase kinase 3(GSK-3),has been widely prescribed mood stabilizer in treatment of bipolar *** suggests that lithium affects monocytic cells,which play pivotal roles in the innate immune systems in both the brain and peripheral *** major studies into the mechanism of action of lithium has been focused on neuron,astrocyte and oligocyte,recent studies indicate that lithium and GSK-3 inhibition also affect immune cells,such as peripheral monocytes,macrophages, monocyte-derived dendritic cells and *** and GSK-3 inhibition are shown to mediate inflammation,microglial migration,monocyte-derived dendritic cells differentiation and reverse monocytic malfunction observed in neuropsychiatric *** confirmed the lithium significantly increased the chemokine production via GSK-3 inhibition in the mouse and human monocytic *** data suggest that clinical treatment of lithium via GSK-3 inhibition by increasing chemokine expression in central/peripheral differentiation monocytic cells directly associate to immune defense system.
Objectives Neuregulin-1(NRG1) is implicated in the etiology or neuropathology of various psychiatric diseases such as schizophrenia and major depression,although its biological contribution to the individual diseases ...
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Objectives Neuregulin-1(NRG1) is implicated in the etiology or neuropathology of various psychiatric diseases such as schizophrenia and major depression,although its biological contribution to the individual diseases is not fully *** evaluate the pathological influences of individual psychiatric diseases on plasma NRG1,we employ an enzyme-linked immunosorbent assay(ELISA) for *** measure NRG1 immunoreactivities in blood plasma of patients with chronic schizophrenia,bipolar disorder,major depression as well as those of healthy *** also attempt to estimate the contribution of single nucleotide polymorphisms(SNPs) ofNRG1 gene to plasma NRG1 levels. Methods We collect plasma of patients with chronic schizophrenia(n =~20),bipolar disorder (n =~20),major depression(n =~20) and healthy volunteers(n =~20).SNPs of NRG1 are genotyped using the TaqMan *** and gender will be matched among *** present study was approved by the Ethics Committee at the First Hospital of Hebei Medical University, and written informed consent was obtained from all participants.
Objective We measured the prevalence of CVD and depression in elderly Chinese citizens living in the community to establish a foundation for a comprehensive CVD treatment and prevention program. Methods We constructed...
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Objective We measured the prevalence of CVD and depression in elderly Chinese citizens living in the community to establish a foundation for a comprehensive CVD treatment and prevention program. Methods We constructed a questionnaire to assess the most frequent CVDs in the community elderly and used the Center for Epidemiology Scale-Depression(CES-D) self-report survey to evaluate the coincidence of depression. Results Among the 3176 participants,the most prevalent CVDs were hypertension(1414/3171, 44.6%),hyperlipidemia(727/3092,23.4%),coronary heart disease(554/3098,17.7%),and angina pectoris(276/3094,8.8%).These CVDs were either more frequent in females,for example,*** symptoms were significantly more prevalent in elderly subjects with angina pectoris,CHD and hypertension,but not hyperlipidemia or arrhythmia. Logistic regression analysis suggested that older age,higher alcohol consumption,and angina were predictors of depression in elderly CVD patients. Conclusions The prevalence of depression is significantly higher in elderly Chinese individuals with angina pectoris,CHD,or hypertension than in the general elderly *** associated with these CVDs may contribute to depression,while depression may exacerbate CVD.
Objective Duloxetine is an antidepressant that effects a serotonergic and noradrenergic neurotransmitter,and a useful agent in the treatment of the patients with anxiety or depressive *** to the recently reported stud...
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Objective Duloxetine is an antidepressant that effects a serotonergic and noradrenergic neurotransmitter,and a useful agent in the treatment of the patients with anxiety or depressive *** to the recently reported study results,combination therapy with 2 antidepressants in the treatment of patients with major depressive disorders did not show a superior efficacy but did show the more adverse events than *** purpose of this study was to evaluate sex differences in effectiveness of duloxetine monotherapy compared to combination therapy with other antidepressants in patients with anxiety or depressive disorders.
Introduction Indonesia with population of 237.5 million has been estimated HIV prevalence of 0.27%among the 15-49 years age ***'s HIV and AIDS epidemic is concentrated amongst key affected population resulting fro...
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Introduction Indonesia with population of 237.5 million has been estimated HIV prevalence of 0.27%among the 15-49 years age ***'s HIV and AIDS epidemic is concentrated amongst key affected population resulting from a mix of two modes of transmission and drug *** cumulative report HIV cases shows infection from injecting use is 36%.Further analysis shows that the proportion of People Who Inject Drugs(PWID) who infected in their first year of engagement is high overtime(2007 and 2011) at 27%and 13%.Percentage of PWID that have received an HIV test in the last 12 months and who know their result is 90.6%.Only 67%
OBJECTIVE The aim of the study was to evaluate the efficacy and safety of long term escitalopram treatment in Major Depressive Disorder(MDD) in Chinese patients with associated anxiety symptoms and assess the effect o...
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OBJECTIVE The aim of the study was to evaluate the efficacy and safety of long term escitalopram treatment in Major Depressive Disorder(MDD) in Chinese patients with associated anxiety symptoms and assess the effect of baseline degree of anxiety on treatment response. METHOD This was a 24-week,single-arm,open-label,multicenter,prospective,long-term *** and female adults(n = 318) aged 18-65 years,inclusive with Diagnostic and Statistical Manual of Mental Disorders,Fourth Edition,text-revision(DSM-1V-TR) criteria-defined major depressive disorder(minimum Montgomery Asberg Depression Rating scale[MADRS]total score of 22) with anxiety symptoms(minimum Hamilton Anxiety Rating scale[HAM-A]total score of 14) received treatment with escitalopram l0 to 20 mg/*** primary efficacy parameter was the remission rate(defined as MADRS<10 and HAM-A<7) at
Low albumin level and subcortical ischemic changes might be associated with cognitive performance in the *** examined the relationship between albumin level,white matter hyperintensity(WMH) and cognitive function amon...
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Low albumin level and subcortical ischemic changes might be associated with cognitive performance in the *** examined the relationship between albumin level,white matter hyperintensity(WMH) and cognitive function among 1038 old adults who were evaluated at the Clinical Research Center for Dementia of South *** samples were drawn from all consenting subjects,and an albumin level was treated as a categorical variable based on quartile. Cognitive function was assessed by the Korean version of Mini Mental State Examination (K-MMSE).We also evaluated the severity of WMH as mild and sever level on brain MRI *** a multivariable adjustment,we could found significant differences in K-MMSE score among albumin level groups(F=6.5,p <0.001) but not between WMH mild and severe groups(t=0.2,p = 0.827),***,the interaction between albumin level and the severity of WMH was shown to be significantly associated with cognitive function(analysis of covariance,F=3.8,p = 0.010).In post hoc tests,a higher K-MMSE score was rather observed in subjects with higher albumin level and severe *** albumin level with severe subcortical ischemic changes appears to be related to cognitive function in old adults.
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