检索结果-内蒙古大学图书馆

您好，读者！请登录

内蒙古大学图书馆

首页
概况
党建
资源
服务
科研支持
- 论文收录引用证明
- 科技查新
知识产权
档案馆
帮助

咨询与建议

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

您的常用邮箱：*

您的手机号码：*

问题描述：

当前已输入0个字，您还可以输入200个字

全部搜索
期刊论文
图书
学位论文
标准
纸本馆藏
外文资源发现
数据库导航
超星发现

高级检索

时间限定

出版年份：

文献类型

图书期刊文献学位论文多媒体

馆藏选择

电子馆藏纸本馆藏

核心期刊

全部期刊 SCI 收录期刊 SSCI 收录期刊 EI 收录期刊 CSCD 收录期刊 CSSCI 收录期刊

语言

中文英文

文献类型

期刊文献图书学位论文标准纸本馆藏

帮助

文字说明：

T=题名（书名、题名），A=作者（责任者），K=主题词，P=出版物名称，PU=出版社名称，O=机构（作者单位、学位授予单位、专利申请人），L=中图分类号，C=学科分类号，U=全部字段，Y=年（出版发行年、学位年度、标准发布年）

检索规则说明：

AND代表“并且”；OR代表“或者”；NOT代表“不包含”；(注意必须大写,运算符两边需空一格)

检索范例：

范例一：(K=图书馆学 OR K=情报学) AND A=范并思 AND Y=1982-2016
范例二：P=计算机应用与软件 AND (U=C++ OR U=Basic) NOT K=Visual AND Y=2011-2016

分类表

所选分类

>> <<

限定检索结果

文献类型

600 篇 会议
1 篇 期刊文献

馆藏范围

601 篇 电子文献
0 种 纸本馆藏

日期分布

学科分类号

530 篇 医学
- 482 篇 临床医学
- 15 篇 公共卫生与预防医...
- 13 篇 中西医结合
- 11 篇 基础医学(可授医学...
- 11 篇 药学(可授医学、理...
- 10 篇 护理学（可授医学、...
- 4 篇 医学技术（可授医学...
- 2 篇 中医学
- 2 篇 中药学(可授医学、...
- 1 篇 特种医学
36 篇 教育学
- 36 篇 心理学(可授教育学...
11 篇 管理学
- 9 篇 公共管理
- 1 篇 管理科学与工程(可...
- 1 篇 工商管理
10 篇 工学
- 5 篇 公安技术
- 4 篇 生物医学工程（可授...
- 1 篇 机械工程
4 篇 法学
- 2 篇 社会学
- 1 篇 法学
- 1 篇 马克思主义理论
4 篇 理学
- 4 篇 生物学
1 篇 经济学
- 1 篇 理论经济学
- 1 篇 应用经济学

主题

58 篇 精神分裂症患者
30 篇 精神分裂症
28 篇 抑郁症患者
24 篇 抑郁症
19 篇 对照研究
15 篇 基因多态性
11 篇 相关性研究
9 篇 panss
9 篇 关联研究
9 篇 利培酮
9 篇 双相障碍
7 篇 阿尔茨海默病
7 篇 相关因素分析
7 篇 氯氮平
7 篇 注意缺陷多动障碍
7 篇 大脑结构网络
6 篇 随访研究
6 篇 信效度
6 篇 抑郁障碍
6 篇 焦虑障碍

机构

40 篇 北京大学
33 篇 北京回龙观医院
26 篇 首都医科大学附属...
26 篇 上海交通大学
25 篇 东南大学
25 篇 南京医科大学附属...
22 篇 南京神经精神病学...
21 篇 中南大学湘雅二医...
15 篇 南京大学
15 篇 河北省第六人民医...
11 篇 广州市脑科医院
11 篇 research center ...
11 篇 academic departm...
11 篇 广州市精神病医院
9 篇 guangzhou psychi...
9 篇 复旦大学附属华山...
8 篇 北京大学第六医院
8 篇 山东省精神卫生中...
8 篇 河北医科大学第一...
8 篇 四川大学华西医院

作者

22 篇 姚志剑
22 篇 阎锐
22 篇 卢青
18 篇 汤浩
18 篇 陈建淮
15 篇 秦姣龙
14 篇 花玲玲
14 篇 杨甫德
11 篇 于欣
11 篇 范宏振
10 篇 谭淑平
10 篇 黄悦勤
8 篇 李凌江
8 篇 lu qing
8 篇 刘肇瑞
8 篇 王健
8 篇 yao zhi-jian
8 篇 崔界峰
7 篇 王学义
7 篇 姚晶

语言

430 篇 中文
171 篇 英文

检索条件"任意字段=中华医学会第十一次全国精神医学学术会议暨第三届亚洲神经精神药理学术会议"

共 601 条记录，以下是511-520 订阅

全选清除本页清除全部题录导出标记到"检索档案"

详细简洁

排序：

血清S100B蛋白、TOC、MDA对利培酮治疗首发未服药精神分裂症患者疗效的影响

血清S100B蛋白、TOC、MDA对利培酮治疗首发未服药精神分裂症患者...

引用

中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者：李艳丽谭云龙杨甫德陈松王志仁谭淑平杨贵刚李佳王月婵于欣周东丰北京回龙观医院北京大学精神卫生研究所

近年来,随着新的生物学技术的介入,在探索精神分裂症的病因及发病机理、精神症状的神经生物学过程等方面取得一定进展,但并无重大突破。诸多研究提示,神经元保护-损伤因素的失衡在疾病发生发展过程中作用关键。S100B是一种Ca结合蛋白,... 详细信息

近年来,随着新的生物学技术的介入,在探索精神分裂症的病因及发病机理、精神症状的神经生物学过程等方面取得一定进展,但并无重大突破。诸多研究提示,神经元保护-损伤因素的失衡在疾病发生发展过程中作用关键。S100B是一种Ca结合蛋白,主要由星型胶质细胞产生和分泌,对神经系统的发育和功能维持起重要作用,脑脊液或血清中S100B浓度升高是神经元破坏的一个敏感性的标志,它的升高提示胶质细胞的活化、神经元的死亡或血脑屏障受损。有学者发现在精神分裂症患者中血清S100B的浓度升高,而且与精神病理症状有关。而自由基含有不配对的电子,在人体内的正常生理代谢中产生,但自由基产生过量会导致细胞功能异常,细胞膜完整性受损,乃至细胞死亡。静息状态下,大脑耗氧量约占心脏输出氧的20%,且含有大量不饱和脂肪酸,儿茶酚胺自身氧化产生自由基,因而大脑容易受自由基损伤。有研究提示,S100B和机体抗氧化系统协同作用,影响患者的精神病理症状。目的①探讨首发未服药精神分裂症患者血清S100B蛋白、丙二醛(Malondialdehyde,MDA)浓度和总抗氧化能力(Total anti-Oxidant Capacity,TOC)变化;分析这些生化指标间的关联及与精神病理症状的关系;②比较利培酮治疗前后血清S100B蛋白、MDA浓度和TOC的变化;③探索基线血清S100B蛋白、TOC、MDA对利培酮治疗首发未服药精神分裂症患者疗效的影响。方法共纳入首发未服药精神分裂症患者61例(疾病组),健康对照66名(对照组);疾病组采用可变剂量利培酮单药治疗8周,分别于治疗基线、第2、4、8周采用阴性和阳性症状(Positive and negative symptoms scale,PANSS)量表评定患者精神病理症状;并于治疗基线和治疗结束取空腹静脉血,采用酶联免疫吸附(Enzyme-Linked ImmunoadsordentAssay,ELISA)法检测血清S100B蛋白浓度,采用分光光度法检测MDA浓度和TOC。分析生化指标、疾病的精神病理症状、疗效间的关系。结果(1)人口学资料:疾病组共纳入首发未服药精神分裂症患者61例(男32例,女29例),年龄(27.3±7.7)岁,发病年龄(24.6±6.2)岁,总病程(48.9±56.5)月;对照组66例(男34例,女32例),年龄(27.4±5.5)岁。2组性别比、年龄无显著差异(P>0.05)。(2)疾病组与对照组S100B、TOC、MDA比较及治疗前后变化:疾病组S100B、TOC显著高于对照组,MDA浓度显著低于对照组(P<0.05);经8周治疗患者血清S100B、TOC、MDA均显著下降,其中MDA下降最为明显(见表1)。(3)利培酮疗效:经8周治疗,患者精神病性症状显著改善,将减分率≥50%定义为显著改善,>30为有效,治疗8周的有效率为88.5%,显著改善率为62.3%,第8周利培酮的治疗剂量为(4.30±1.24)mg/d。(4)基线血清S100B、TOC、MDA间及与精神病理症状的关系:相关分析结果提示,S100B浓度与TOC、MDA、病程、PANSS阴性症状分、PANSS总分显著相关,TOC与S100B浓度、PANSS阴性症状分、PANSS总分显著相关。S100B与机体抗氧化系统可能存在某种协同作用,共同影响精神分裂症患者精神病症状。(5)血清S100B、TOC、MDA对疗效的影响:S100B浓度与PANSS减分率显著负相关,TOC与减分率相关趋于显著水平(P=0.055);此外,病程与PANSS减分率显著负相关(见表2)。结论首发精神分裂症患者S100B与机体抗氧化体系可能存在交互作用,共同影响疾病症状和抗精神病药物对患者的治疗反应。

关键词：利培酮精神分裂症患者 MDA S100B TOC

来源：评论

学校读者我要写书评

暂无评论

儿童精神分裂症外周血白细胞LncRNA表达谱分析

儿童精神分裂症外周血白细胞LncRNA表达谱分析

引用

中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者：徐勇李忻蓉孙宁胡晓东张克让山西医科大学第一医院山西医科大学心理卫生研究所

目的儿童精神分裂症神经发育异常的可能性更大。本研究拟以精神分裂症儿童患者及精神分裂症前驱期儿童外周血白细胞筛选进行精神分裂症特异的lncRNAs的筛选。方法样本纳入与排除:精神分裂症入组标准(组1):11岁≤年龄≤15岁;汉族;患者符... 详细信息

目的儿童精神分裂症神经发育异常的可能性更大。本研究拟以精神分裂症儿童患者及精神分裂症前驱期儿童外周血白细胞筛选进行精神分裂症特异的lncRNAs的筛选。方法样本纳入与排除:精神分裂症入组标准(组1):11岁≤年龄≤15岁;汉族;患者符合DSM-Ⅳ关于精神分裂症的诊断标准;阳性与阴性症状量表量表(PANSS)评分>60分;儿童韦氏智力测验IQ>70分。未经治疗、首发儿童精神分裂症;家属或监护人同意参加本研究。排除标准:患有重大躯体疾病或有颅脑外伤史;头颅CT和脑电图提示:先天畸形等神经系统疾病;患者有精神发育迟滞和全面发育障碍。入组前4周服用任何精神科药品治疗者等。精神分裂症前驱期入组标准(组2):年龄性别与病例组相匹配;使用精神病

关键词：儿童精神分裂症精神分裂症患者 LncRNA 外周血白细胞

来源：评论

学校读者我要写书评

暂无评论

Effective connectivity of core emotional brain areas under positive and negative stimulus

Effective connectivity of core emotional brain areas under p...

引用

中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Bi Kun Liu Chu Yao Zhi-jian Lu Qing Research Center of Learning Science Southeast University Academic Department of Psychiatry Nanjing Brain HospitalNanjing Medical University

PurposeSome findings showed that subcortical areas,such as amygdala on the expression of emotional behavior,play an important role in cognitive processing emotions. However,the prefrontal cortex and anterior cingulate cortex are the critical areas of regulating emotional state and expressing emotional *** addition,compared with the healthy controls,depressive patients are more sensitive to negative *** the contrary,it is insensitive to the positive *** this paper,the amygdala,anterior cingulate cortex and dorsolateral prefrontal cortex were selected as interested *** explored the difference of effective connectivity between depressive patients and healthy controls under positive and negative stimulation. Method Magnetoencephalography data from the CTF275 head type MEG system were acquired,sampling at a rate of 1200 *** were 24 depressive patients and 24 cases matched healthy *** amygdala,dorsolateral prefrontal cortex and anterior cingulate cortex were selected as interested *** preprocessing and source reconstruction of magnetoencephalography signal were undertaken via *** MEG recordings under neutral, sad and happy stimuli were chosed for *** under the neutral stimuli were taken as the *** granger causality model was applied to calculate the effective connectivity under positive stimulation and negative stimulation *** permutation test was used to compare differences between groups. Results Compared with healthy controls,the effective connectivity between the amygdala and the dorsolateral prefrontal cortex under negative stimulation decreased significantly in the ***,the effective connectivity from the dorsolateral prefrontal cortex to the amygdala increased significantly under positive *** significant difference was found in the connectivity of other regional pairs. Conclusion Depression patients are more sensitive to negative stimulus,and easier

关键词： Effective connectivity of core emotional brain areas under positive and negative stimulus

来源：评论

学校读者我要写书评

暂无评论

One-year rehospitalization rates in patients with first-episode bipolar mania on lithium and valproate with adjunctive atypical antipsychotics

One-year rehospitalization rates in patients with first-epis...

引用

中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Young Sup Woo Won-Myong Bahk Jong-Hyun Jeong Jong-Hyuk Choi Department of Psychiatry Chuncheon National hospitalChuncheonKorea Department of Psychiatry College of MedicineThe Catholic University of KoreaSeoulKorea

Objective:We compared the one-year rehospitalization rates of first-episode bipolar manic patients who were discharged while being treated with lithium or valproate in combination with an atypical antipsychotic. Methods We investigated the rehospitalization status of the first-episode bipolar manic patients who were discharged between January 1,2003 and December 31,2010 while they were taking lithium or valproate in combination with aripiprazole,olanzapine,quetiapine or risperidone. Rehospitalizations over a 1-year period after discharge were compared between the lithium plus an atypical antipsychotic group and valproate plus an atypical antipsychotic group,using the Kaplan-Meier *** regression model was used to analyze covariates thought to affect time to rehospitalization. Results The rehospitalization rate was 17.3%during the 1-year follow-up *** was significant differences in rehospitalization estimated using the Kaplan-Meier formula among the patients in the lithium group(23.1%) and valproate group(13.3%).By Cox proportional hazards regression analysis,lower Global Assessment of Functioning(GAP) score at discharge(p = 0.018) and lithium treatment(p = 0.034) contributed to the risk of rehospitalization. Conclusions Valproate treatment with an atypical antipsychotic significantly reduced risk of rehospitalization during the 1 year after discharge from hospitalization due to the first onset manic episode in bipolar I *** GAF score at discharge also negatively affected the rehospitalization rate.

关键词： One-year rehospitalization rates in patients with first-episode bipolar mania on lithium and valproate with adjunctive atypical antipsychotics

来源：评论

学校读者我要写书评

暂无评论

Critical period of inhibitory effect of methylphenidate on hyperactivity in dopamine transporter knockout mice

Critical period of inhibitory effect of methylphenidate on h...

引用

中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Yukio Takamatsu Yumiko Kubo Sarah Yukie Nagasawa George R.Uhl Ichiro Sora Kazutaka Ikeda Department of Developmental Medical Sciences Graduate School of MedicineThe University of Tokyo Department of Psychiatry Kobe University Graduate School of Medicine

Objective Attention-deficit/hyperactivity disorder(AD/HD),characterized by symptoms of inattention and hyperactivity-impulsivity,is a common neurodevelopmental disorder of childhood that often persists into adult *** dopamine transporter(DAT) knockout(KO) mice show hyperactivity which can be treated with methylphenidate,DAT-KO mice are considered model mice for AD/***,there have been few studies that focused on postnatal development of DAT-KO *** investigated association between postnatal development and methylphenidate induced inhibition of hyperactivity in DAT-KO mice. Methods Wildtype and DAT-KO mouse littermates from crosses of heterozygous/heterozygous DAT-KO ***-KO mice at 2,4,8,12,16,20 weeks were used to investigate the impact of the deletion of DAT on activity in the open-field,and then treated with methylphenidate(60 mg/kg) at 4,8 and 12 weeks. Results DAT-KO mice already exhibited hyperactivity at 2 *** inhibited hyperactivity in DAT-KO mice at 12 weeks,but not at 4 and 8 weeks. Conclusion These results suggest that there is a critical period for methylphenidate induced inhibition of hyperactivity in DAT-KO *** ineffectiveness of methylphenidate in developing DAT-KO mice may be related to insufficient evidence for methylphenidate effects on AD/HD patients before 7 years old.

关键词： Critical period of inhibitory effect of methylphenidate on hyperactivity in dopamine transporter knockout mice

来源：评论

学校读者我要写书评

暂无评论

Association between sleep and mild cognitive impairment in elderly people Running title:Effects of sleep on cognitive function

Association between sleep and mild cognitive impairment in e...

引用

中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Cuixia An Lulu Yu Minwei Wang Xueyi Wang The Mental Health Institute of Hebei Medical University

Objective To compare the sleep quality between patients with mild cognitive impairment(MCI) and normal elderly,and analyze the effects of sleep on cognitive function. Methods 320 cases of MCI patients(MCI group) and 630 normal elderly with matched age, gender and years of education(control group) were enrolled in this *** sleep quality index(PSQI) was used to assess the sleep ***-mental state examination(MMSE) and Montreal Cognitive Assessment(MoCA) were used to assess the cognitive function. Results There were 110(34.3%) and 170(27%) cases with sleep disorders in MCI group and control group,respectively(P<0.01).There was significant difference of total PQSI scores between two groups,and the scores of sleep duration(factorⅢ) and habitual sleep efficiency (factorⅣ) in MCI group were significantly lower than control group,*** PQSI scores were negatively correlated with MoCA scores and MMSE scores,*** scores were negatively correlated with scores of sleep latency(factorⅡ),sleep duration(factorⅢ),habitual sleep efficiency(factorⅣ),respectively,and MMSE scores were negatively correlated with scores of factorⅢand factorⅣ,*** scores of attention and calculation,reading and language understanding,and visuospatial function(MMSE),and visuospatial and executive function,attention and clock drawing test(MoCA) in MCI patients without sleep disorders were significantly higher than those in MCI patients with sleep disorders, respectively. Conclusion The incidence of sleep disorders is higher in patients with MCI,compared with normal *** of sleep on cognitive function are mainly reflected in attention,and visuospatial and executive function.

关键词： Association between sleep and mild cognitive impairment in elderly people Running title:Effects of sleep on cognitive function

来源：评论

学校读者我要写书评

暂无评论

Determinants of suicidal ideation in patients with breast cancer

Determinants of suicidal ideation in patients with breast ca...

引用

中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Jin-Sang Yoon Young-Woo Park Jae-Min Kim Ji-Eun Jang Department of Psychiatry Chonnam National University Medical Schooland Depression Clinical Research CenterChonnam National University HospitalGwangjuKorea

Background Breast cancer survivors are at higher risk of psychological problems including suicidal ***,studies on suicidal ideation in breast cancer survivors have been rare and have not been investigated *** study aimed to investigate the prevalence and independent risk factors for suicidal ideation within one week and at one year after breast surgery for breast cancer. Methods A total of 284 patients with breast cancer were evaluated within 1 week after breast surgery,and 244(84%) were followed one year *** ideation was ascertained using the item "suicidal thoughts" from the Beck Depression *** Factors potentially related to suicidal ideation were evaluated including sociodemographic and clinical characteristics,and genetic polymorphisms on serotonin and brain derived neurotrophic factor(BDNF) systems. Results Suicidal ideation was present in 10.9%of participants at 1 week and 11.4%at 1 year after breast *** ideation was independently associated with depression and physical disability at 1 week;and with living alone,anxiety,advanced cancer stage,and the BDNF met allele(but not with genetic polymorphisms on serotonergic system) at 1 year after breast surgery. Conclusion Suicidal ideation was common and had similar prevalences in both short and longer-term follow-up after breast ***,associated factors were substantially different between the two evaluation points which suggest that time-specific programs may be needed for identifying and managing suicidal risk in patients with breast cancer.

关键词： Determinants of suicidal ideation in patients with breast cancer

来源：评论

学校读者我要写书评

暂无评论

The Effects of Smoking Cessation on Gene Expression

The Effects of Smoking Cessation on Gene Expression

引用

中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Dai-Jin Kim The Catholic University

Background:Cigarette smoking affects the prevalence of many diseases such as lung cancer and cardiovascular *** of chemical compositions are responsible for these diseases-related symptoms,including immune response,but the associated molecular alterations caused by smoking were not fully ***,we monitored and compared the gene expression of heavy smokers who succeeded or failed in smoking cessation. Methods We gathered 12 male nicotine dependent patients and they were asked to carry out 2 months of smoking *** a result,6 of them achieved abstinence(success group) and the rest of them failed(failure group).Their gene expression profiling was performed using a microarray of 30,398 features,then real-time PCR was conducted for selected genes;HEPACAM family member 2(HEPACAM2),tropomodulin 1(TMOD1),ubiquitin specific peptidase 18 (USP18) and interferon-induced protein 44(IFI44). Results Among 30,398 features,229 features were differently expressed between the two groups of ***,HEPACAM2(p = 0.024) and TMOD1(p <0.001) genes were more expressed,and USP18(p = 0.033) expression was lower in the success ***,the expression of IFI44 in the success group was not significantly distinguished from that of IFI44 in the failure group. Discussion Through smoking cessation,the variety of genes expression could change such as immunity,cytoskeleton,cell adhesion,cell proliferation and cancer-related ***,the elevation of HEPACAM2 and TMOD1 expression,and the decrease of USP18 expression after cessation might be connected with the decline in the risk of cigarette smoking-associated cancers. It is critical that the smoking cessation was succeeded not by medication but by ***, perhaps the resulting genes would be the biomarkers to support smoking-associated diseases and could explain related mechanisms that are caused by tobacco smoking.

关键词： The Effects of Smoking Cessation on Gene Expression

来源：评论

学校读者我要写书评

暂无评论

A New Screening Method of Antipsychotic Chinese Herbal Active Ingredients

A New Screening Method of Antipsychotic Chinese Herbal Activ...

引用

中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Yan Zhang Jianguo Shi Feihu Liu Xi'an Institute of Mental Health Xi'anShaanxiChina

Objectives to establish a screening method of SH-SY5Y cell membrane chromatography(SH-SY5Y/CMC) for recognition,separation and identification of active components on antipsychotic from traditional Chinese medicines(TCMs). Methods SH-SY5Y cells by means of culture with SH-SY5Y cell lines were used for preparation of the stationary phase in the CMC *** components by the SH-SY5Y/CMC model were collected and active components then analyzed by SH-SY5Y/CMC under the optimized *** investigating the suitability and reliability of the SH-SY5Y /CMC method using risperidone,sertraline and clozapine as standard compounds,this method was applied in screening active components from the extracts of TCMs such as Radix Gentianae, Radix Bupleuri,stir-baked semen ziziphi spinosae,rehmannia dride rhizome,uncaria rhynchophylla. Results Retention components from the extracts in the SH-SY5Y/CMC model were gentiopicrin and rosmarinci acid identified by the GC/MS *** vitro pharmacological trials indicated that gentiopicrin and rosmarinci acid could concentration dependently protect the SH-SY5Y pre-treated by H202(P value less than 0.05). Conclusion The SH-SY5Y/CMC method is an effective screening system that can rapidly detect target components from a complex sample for antipsychotic candidate drug.

关键词： Active A New Screening Method of Antipsychotic Chinese Herbal Active Ingredients

来源：评论

学校读者我要写书评

暂无评论

Oral Anti-Diabetic Medications in Relation to Dementia

Oral Anti-Diabetic Medications in Relation to Dementia

引用

中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Chin Cheng Ching-Heng Lin Tsuo-Hung Lan Department of Psychiatry National Yang-Ming University Department of Public Health and Primary Care University of Cambridge Department of Research Taichung Veterans General Hospital

Objectives Type 2 diabetes(T2D) has been shown to increase dementia risk. Patients with T2D have to take anti-diabetic medications on a regular ***,the association between anti-diabetic medication and cognitive function in older people is not clear. The objectives of this study were to investigate:(i) The risk in developing dementia among T2D patients,and(ii) The risk in developing dementia among T2D patients receiving different types of anti-diabetic medications. Methods We examined 64,499 subjects aged 65 or older,dementia-free and T2D-free,to observe onset of T2D and the development of dementia,and the risk of developing dementia associated with particular types of anti-diabetic medication in patients with T2D. Results The hazard ratio(HR) of dementia event in T2D patients compared with the non-T2D subjects was *** T2D patients(n=l,921),the independent HR of dementia was 4.70 for patients taking thiazolidinediones compared with those taking metformin,but the risk remained the same between patients taking sulfonylureas and *** risk decreased 14.9%and 13.15%for every 10%increase in medication possession ratio(MPR) in sulfonylureas and metformin groups,respectively,while there was no such association in thiazolidinediones. Discussion Diabetes is independently associated with an increased risk of *** risk effect becomes weaker provided that the patients take sulfonylureas or metformin rather than thiazolidinediones for a longer period.

关键词：

来源：评论

学校读者我要写书评

暂无评论

没有更多数据了...

全选清除本页清除全部题录导出标记到“检索档案”

共61页 << < 48 49 50 51 52 53 54 55 56 57 > >>

检索报告对象比较合并检索0

隐藏清空

合并搜索

回到顶部

执行限定条件

内容：

评分：

请选择保存的检索档案：

请选择收藏分类：

订阅名称：

通借通还

温馨提示：

图书名称：

借书校区：

取书校区：

手机号码：

邮箱地址：

一卡通帐号：

电话和邮箱必须正确填写，我们会与您联系确认。

联系人：

所在院系：

联系邮箱：

联系电话：

内蒙古自治区呼和浩特市赛罕区大学西街235号邮编: 010021

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：