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Insight in patients with manic disorder

Insight in patients with manic disorder

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Li Liang Changqing Yufen Ou Yuanfei Wu Yuwei Chen Yuping Ning Hongbo He Guangzhou Psychiatric Hospital

Objectives The impairment of insight is a common feature for the affective disorder and it is associated with poor adherence to treatment and clinical *** about insight in affective disorder have not been as developed as in *** aim of the present study was to evaluate the level of insight in patients with current manic episodes,and to determine its relationship with manic symptoms,treatment compliance and socio-epidemiological variables. Methods Inpatients in Guangzhou Psychiatric Hospital(GPH) with manic disorder including bipolar disorder and simple manic disorder according to DSM-Ⅳcriteria participated in the *** whose mood disorder derived from a general medical condition or alcohol and other substances abuse,were ruled *** the participants did not have mental retardation,dementia or other organic *** symptoms were measured by the Positive and Negative Syndrome Scale for Schizophrenia(PANSS).Insight was assessed by the Insight and Treatment Attitudes Questionnaire(ITAQ),which consists of 11 items and each item rated from 0-2(with higher scores indicating better insight).Treatment compliance was reflected with attitudes towards medication assessed by The Drug Attitude Inventory(DAI).Written informed consent was signed after *** socio-demographic data were collected from medical records, and YMRS,ITAQ and DAI were evaluated by trained psychiatrists both in a week after admission and a week prior to *** Statistical Package for Social Science(SPSS) Windows version 16.0 was used for data *** statistics were computed for sociodemographic and clinical ***-samples t test was used to examine the improvement of insight and treatment compliance after inpatient *** correlations were calculated for ITAQ of both during admission and discharge with the clinical symptoms measured with YMRS and the treatment compliance assessed by DAI *** l

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The Betweenness Centrality of Nodes in Weighted Structural Cortical Networks in Schizophrenic patients

The Betweenness Centrality of Nodes in Weighted Structural C...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： CHEN Jian-Huai YAO Zhi-jian QIN Jiao-Long LU Qing Academic Department of Psychiatry Nanjing Brain HospitalNanjing Medical University Research Center of Learning Science Southeast University

Objective The betweenness centrality of an individual node is defined as the fraction of all shortest paths in the network that pass through the node.A node with high betweenness centrality can control information flow because it is at the intersection of many short *** centrality characterizes the influence or centrality of a node from the viewpoint of the flow or dynamic process occurring on the *** identification of highly influential nodes on the basis of graph topology represents a step toward the classification of network elements in terms of their potential functional ***,DTI tractography and graph theoretical approaches were used to compare the differences of the betweenness centrality of the nodes in the brain weighted white matter(WM) networks of the schizophrenia and the healthy. Method This study included 26 schizophrenia patients and 29 age- and gender-matched healthy controls were *** participants were scanned with a 3-Tesla scanner with a 8-channel radio frequency coil MRI scanner in the Nanjing Brain *** tensor imaging and deterministic tractography were used to map the weighted cortical networks of the participants. To determine the nodes of brain networks,the automated anatomical labeling(AAL) template was used to parcellate the whole cerebral cortex into 90 areas(45 regions in each hemisphere). And to define the network edges,a threshold value(Two regions were considered structurally connected at least 2 fibers with 2 end points were located in these 2 regions) was selected for the fiber *** the weighted white matter(WM) networks were constructed with FA(The FA value is an important index to evaluate fiber integrity and has a high correlation with conductivity) as the weight of each *** theoretical methods were applied to investigate the differences of the betweenness centrality of the nodes in the brain weighted WM networks of the schizophrenia and the healthy. Result When compa

关键词： The Betweenness Centrality of Nodes in Weighted Structural Cortical Networks in Schizophrenic patients

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重复经颅磁刺激治疗抑郁症的技术优化研究。

重复经颅磁刺激治疗抑郁症的技术优化研究。

引用

中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Xiaoyan Ma Yueqin Huang Yi Jin Zhaorui Liu Institute of Mental Health Peking University

Objective The aim of this study was to optimize therapeutic parameters for major depressive disorder by means of repetitive transcranial magnetic stimulation(rTMS) with different locations[the left dorsolateral prefrontal cortex(DLPFC) by figure-8 coil and the bilateral prefrontal cortex(BPFC) by round coil]and frequencies(5Hz vs 10Hz). Method The study was a randomized,double-blind,sham-controlled,multicenter clinical trial. Subjects consisted of 124 patients with DSM-Ⅳdiagnosed major depressive disorder (MDD).The patients enrolled in the trial were randomly assigned into 4 different treatment groups according to coil type,stimulation location and frequence:(1) figure-8 coil combined with 10Hz in DLPFC,(2) figure-8 coil combined with 5Hz in DLPFC,(3) round coil combined with 10Hz in BPFC,and(4) round coil combined with 5Hz in *** who did not take any medication or completed two-week wash-out period for this latest depressive episode were recruited into the *** the entire study,participants were requested not to take any antidepressants and antipsychotic *** subjects were assessed by Hamilton Rating Scale for Depression(HRSD-24 item) and Clinical Global Impression(CGI-S) at baseline and weekly after treatment of rTMS to evaluate the *** subjects received 30-minute treatment once a day,five days a week,totally 6-week to 12-week *** clinical raters and the patients were blind to treatment and the subjects were rated weekly by clinical raters. Magstime Rapid 2 was used in the *** mearsure analysis of variance(MANOVA) was used to test the effects of treatment,course of treament and their interaction for the each data set of Intention to treat(ITT) and Per-protocol(PP).Generalized estimating equation(GEE) was used to test the effets of treatment,clinical response rate and remission rate in the four groups. Results(1) Twenty-two patients in figure-8 coil with 10Hz group,27 patients in figure-8 coil with 5Hz group,

关键词：重复经颅磁刺激治疗抑郁症优化研究

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缓解期精神分裂症心理年龄滞后及相关因素分析

缓解期精神分裂症心理年龄滞后及相关因素分析

引用

中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

目的通过对缓解期精神分裂症心理年龄的评定从社会心理因素了解缓解期精神分裂症心理年龄滞后现象,分析其与应对方式、防御方式的相关性。方法采用自编心理年龄评估问卷(该问卷根据埃里克森的心理发展观对不同年龄发展阶段的发展任务的... 详细信息

目的通过对缓解期精神分裂症心理年龄的评定从社会心理因素了解缓解期精神分裂症心理年龄滞后现象,分析其与应对方式、防御方式的相关性。方法采用自编心理年龄评估问卷(该问卷根据埃里克森的心理发展观对不同年龄发展阶段的发展任务的描述改编而成)、应付方式问卷及防御方式问卷(DSQ),对来源于2012年9月至2012年11月在河北省第六人民医院就诊的171例缓解期精神分裂症患者进行评估。结果:171例精神分裂症患者通过心理年龄评定,医生评定心理年龄为11.08±3.52岁,与实际年龄比较差异有统计学意义(t=28.972,P<0.001);患者自评心理年龄为31.77±11.59岁,与实际年龄比较差异有统计学意义(t=2.667,P=0.008);照料者评定心理年龄为21.13±10.94岁,与实际年龄比较差异有统计学意义(t=17.269,P<0.001)。通过与实际

关键词：缓解期精神分裂症实际年龄河北省第六人民医院精神分裂症患者心理年龄防御方式问卷相关因素分析

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The mRNA and miRNA Expression of Dopamine Related Genes in the Rats with Chronic Stress

The mRNA and miRNA Expression of Dopamine Related Genes in t...

引用

中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者：张艳华禹顺英沈一峰李华芳复旦大学附属华山医院精神科上海交通大学医学院附属精神卫生中心

Objectives To explore the effects of chronic unpredictable mild stress on the expression of dopamine related genes(including tyrosine hydroxylase,dopamine transporter,dopamine Dl receptor,dopamine D2 receptor,dopamine D3 receptor and prostate apoptosis response-4) and differential expression of microRNA profile in nucleus accumbens of depressive animal models;Methods *** the CUMS trial,16 SD rats were randomly assighed to chronic stress group or control *** group had 8 *** in chronic stress group underwent 1-2 unpredictable mild stress each day for 6 *** weight was measured each week;Sugar preference test was evaluated every 3 *** field was used to measure animals' *** were sacrificed after the trial and nucleus accumbens were taken. *** mRNA expression of dopamine related factors were measured by RT-PCR. *** two samples of nucleus accumbens from each group and miRNA sequencing was used to detect differential expression of miRNA profile. Results *** in CUMS group had lower weight gain(240.91±27.59g vs 156.30±15.78g) and sugar preference(.73±.10 vs.60±.14) than control group,while the behavior in open field increased in CUMS group compared with control group. *** mRNA expression of dopamine related genes had no difference between two groups in the CUMS trial. 3.25 miRNAs were obviously down-regulated and 2 up-regulated in CUMS group. Conclusions *** mRNA expression of dopamine related genes may not be affected by CUMS in rats. *** expression of some miRNAs may be changed by chronic unpredictable mild stress.

关键词： miRNA The mRNA and miRNA Expression of Dopamine Related Genes in the Rats with Chronic Stress

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The association of insight with clinical symptoms and therapeutic side effects in patients with schizophrenia

The association of insight with clinical symptoms and therap...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Jie Zhang Robert Rosenheck Somaia Mohamed Yanling Zhou Yingmei Chen Weijie Huang Yuping Ning Hongbo He Guangzhou Psychiatric Hospital GuangzhouChina Yale Medical School New HavenCTUSA

*** Poor insight and denial of illness have been found to be among the most common symptoms of *** studies have shown that loss of insight is correlated with severity of clinical symptoms,poor treatment adherence,poor prognosis,and increased relapses and readmission *** the other hand,comparatively greater insight in psychiatric patients has been associated with clinical symptoms of depression and increased suicidal ideation and worse side *** this study,we recruited schizophrenic inpatients in a large psychiatric hospital in south China to examine the relationship between insight,clinical symptoms,and therapeutic side effects. *** *** In-patients from ages 18 to 60 with schizophrenia based on ICD-10 diagnostic criteria were recruited. *** Clinical *** symptoms were measured by the Positive and Negative Syndrome Scale for Schizophrenia(PANSS).The five-factor model,negative,positive,disorganization, excitement and depression/anxiety factors,was used in this study. *** was assessed by the Insight and Treatment Attitudes Questionnaire(ITAQ).It consists of 11 items and each item rated from 0-2(with higher scores indicating better insight). Therapeutic side *** Treatment emergent symptoms scale(TESS) was used to assess adverse effect during the *** 34 items were classified as 6 groups:toxic symptom, abnormal test,nervous system,vegetative nervous system,cardiovascular and others(including skin allergy,weight gain,weight reduction,anorexia,headache and TD). *** Written informed consent was signed after *** socio-demographic data were collected from medical records,and PANSS,ITAQ and TESS were evaluated by trained psychiatrists a week before discharge. *** analysis Descriptive statistics were computed for socio-demographic and clinical variables. Bivariate correlations were calculated for two dimensions of the ITAQ and the overall in

关键词： The association of insight with clinical symptoms and therapeutic side effects in patients with schizophrenia

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Antipsychotics Prescribing Patterns of Patients with First-episode Schizophrenia in Korea:A comparison of 2005 and 2010

Antipsychotics Prescribing Patterns of Patients with First-e...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Daeyoung Roh Jhin-Goo Chang Sung Kil Min Chan-Hyung Kim Severence Mental health Hospital Institute of Behavioral Science in Medicine Yonsei University College of MedicineKorea Severence Mental health Hospital

Purpose Since the first-episode of psychosis is known to be a critical period,there has been an increased focus on the first-episode *** purpose of this study was to quantify and describe recent prescribing trends of antipsychotics use in patients with first-episode schizophrenia by comparing prescription patterns between the year 2005 and the year 2010. Especially in 2005,most of the commonly used 2nd generation antipsychotics were equipped in Korea,including aripiprazole granted approval for use in 2004. Methods In this retrospective study,we reviewed the medical records of patients discharged from Severance mental health hospital,a part of the unit of psychiatry,Yonsei University College of Medicine in 2005 and *** medication profiles were reviewed for the patients who were diagnosed as having schizophrenia or schizophreniform disorder(DSM-IV-TR, 4th edition) at the time of *** dosing of antipsychotics was calculated by prescribed daily doses(PDD) / defined daily doses(DDD) ratio. Results A sample of 47 records were reviewed for 2005 and 52 were reviewed for 2010. Significantly more individuals were treated with mood stabilizers in 2010 than in 2005(0% vs17.3%,p <0.01).In 2005,the four common first-prescribed antipsychotics after being diagnosed schizophrenia were olanzapine(34%),risperidone(34%),aripiprazole(23%) and haloperidol(19.1%).The list of commonly prescribed antipsychotics changed into risperidone (36.5%) quetiapine(23.1%),paliperidone(23.1%) and olanzapine(17.3%) in *** was no significant difference in antipsychotic dose of PDD/DDD ratio(2.06±1.07 vs 2.02±1.16) and prevalence of antipsychotic polypharmacy(34.0%vs 34.6%) between 2005 and *** regression analysis revealed that high dose antipsychotics were significantly associated with antipsychotic polypharmacy.(OR = 8.68,P <0.01) Conclusion Despite the change of the list of commonly prescribed antipsychotics,the use of antipsychotic polypharmacy wi

关键词： Antipsychotics Prescribing Patterns of Patients with First-episode Schizophrenia in Korea:A comparison of 2005 and 2010

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Facial Emotion Recognition in Children with Attention Deficit Hyperactivity Disorder

Facial Emotion Recognition in Children with Attention Defici...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Byeong Moo Choe Jae Hong Park

Objectives Children with Attention Deficit Hyperactivity Disorder(ADHD) exhibit significant impairments in their social ***,the underlying causes of their social dysfunction have not been *** ability of emotion recognition may be one of causes of social dysfunction in *** study examined facial emotion recognition of children with ADHD and their correlation between inattention/impulsivity and social dysfunction. Methods The participants consisted of 53 children between the age 7 and 12(31 ADHD,22 control group).All subjects had one session of the Emotion Recognition Test-40(ER-40) to evaluate abilities of facial emotion *** examine inattention and impulsivity of ADHD group,visual Continuous Performance Test(CPT) and ADHD Rating Scale-Ⅳ(ARS-Ⅳ) were *** function of ADHD group was assessed by social score of Child Behavioral Check List(CBCL). Results ADHD group had a significant lower score of anger(-0.55±0.94,p=0.04) and fear (-2.16±1.68,p<0.01) stimuli than control *** were no significant differences between groups to recognize happy,sad and neutral stimuli. In ADHD group,there were no significant correlations among visual CPT omission error/commission error,ARS-IV inattentive/impulsiveness score and the scores of ER-40. Among the ER-40 scores,sad(r=0.41,p=0.02),anger(r=0.40,p=0.03) and fear(r=0.63,p<0.01) scores were positively correlated with CBCL social *** stepwise linear regression analysis revealed that fear score of ER-40(β=0.63,p<0.01) and commission error score of CPT(β= -0.47, p=0.03) significantly affected CBCL social score. Conclusions Results of this study show that children with ADHD have poor emotion recognition performance on two types of facial emotion(anger,fear).And inattention and impulsivity did not contribute this type of error in emotion *** in recognizing the facial emotion might contribute the social problem experienced by children with ADHD.

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Contingent negative variation in first episode deficit and non-deficit schizophrenia

Contingent negative variation in first episode deficit and n...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： LI Zhe DENG Wei ZHENG Zhong LI Tao The Mental Health Center West China HospitalSichuan University

Objective To detect the contingent negative variation(CNV) in first episode deficit and non-deficit schizophrenia and the relationship between CNV and clinical variables. Methods Nihon Kohden evoked brain potentials machine were used to measure CNV in 60 patients with non-deficit schizophrenia(NDS),50 patients with deficit schizophrenia(DS ) and 60 unrelated healthy controls(HC).Click-flashing paradigm was used to record the *** clinical status of patients with schizophrenia was determined using the Positive and Negative Syndrome Scale(PANSS).The overall functioning status was assessed using the Global Assessment of Functioning Scale(GAF).Partial correlations were computed to explore associations among the CNV in DS and the clinical data. Results Compared to HC,both DS and NDS groups showed significantly reduced amplitude of B(F=27.38,P = 0.00),significantly delayed reaction time(F=50.30,P = 0.00).Compared to HC,DS group showed the course of PINV significantly shorten,whereas NDS group showed significantly delayed(F=15.32,P = 0.00).Only DS,when compared with HC,showed delayed latency of point A in *** was no significantly difference among three groups in both area of A-S2'(F=234,P = 0.10) and area of PINV(F=1.07,P = 0.35).Amplitude of B and the course of PINV in DS group correlated negative with PANSS subscale of negative symptoms (r=-0.94,-0.89,respectively,P<0.05),whereas in NDS group amplitude of B correlated negative with PANSS subscale of positive symptoms(r =-0.87,P <0.05 ),but the course of PINV PANSS correlated positive with PANSS subscale of positive symptoms(r =0.88,P <0.05). Latency of point A in CNV,which was delayed in DS group,correlated negative with GAF(r =-0.62,P<0.05). Conclusions Generalized abnormalities of CNV existed in DS and NDS,while DS maybe more impairment in CNV than *** latency of point A in CNV may predict the function outcome of DS.

关键词： Contingent negative variation in first episode deficit and non-deficit schizophrenia

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Interaction of Resting-state Networks in Major Depressive Disorder

Interaction of Resting-state Networks in Major Depressive Di...

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中华医学会第十一次全国精神医学学术会议、第三届亚洲神经精神药理学术会议

作者： Maobin Wei Rui Yan Zhijian Yao Qing Lu Research Center of Learning Science Southeast University Academic Department of Psychiatry Nanjing Brain HospitalNanjing Medical University

Objective It has been reported that depressive symptoms may evolve as a consequence of aberrations within discrete brain functional *** further help our understanding of the abnormalities of networks,we explore the interaction of resting-state networks in major depression. Methods Twenty patients with major depressive disorder and 20 matched healthy controls were scanned with MR Scanner(Siemens,3.0 Tesla).Resting-state functional MRI data were acquired with gradient-echo EPI sequence,and high resolution T1-weighted structural images were used for coregistration of function *** data were preprocessed by spm8,including slice-timing,motion correction,spatial normalization,and spatial *** preprocessed data were further input to the Group ICA of functional MRI Toolbox *** resting-state networks of the extracted 20 components were selected by a network template matching *** connectivity between networks was computed and the statistical analysis was conducted to explore the abnormality of network connectivity in major depressive disorder. Results The selected networks were the left and right fronto-parietal network,the anterior and posterior default mode network,the lateral and primary visual network,the cerebellum network, the salience network,the auditory network,the ventral medial prefrontal network and the fronto-temporal *** contrast with healthy controls,the patients with major depressive disorder exhibited significantly decreased connectivity between the cerebellum network and the lateral visual network(p = 0.042),however,increased connectivity between the cerebellum network and the posterior default mode network(p = 0.046),and increased connectivity between the fronto-temporal network and the right fronto-parietal network(p = 0.025). Conclusion The results demonstrated abnormal interaction of resting-state networks in the major depressive *** increased connectivity between the cerebellum network and the po

关键词： Interaction of Resting-state Networks in Major Depressive Disorder

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