Background Mouse model has been widely utilized to understand the basic principles of follicle assembly, initiation of follicular development and the role of specific growth and differentiation *** of their natural en...
详细信息
Background Mouse model has been widely utilized to understand the basic principles of follicle assembly, initiation of follicular development and the role of specific growth and differentiation *** of their natural environment,ovaries must cope with physical *** importantly,eliminating in vivo regulation system may lead altered follicular *** present,the methods of ovarian incubation mainly include in vitro cul-
Thyroid hormone(TH) is essential for the proper development of mammalian central nervous *** hormone deficiency during critical period of brain development results in permanent cognitive and neurological *** is a stru...
详细信息
Thyroid hormone(TH) is essential for the proper development of mammalian central nervous *** hormone deficiency during critical period of brain development results in permanent cognitive and neurological *** is a structure involved in various memory processes that are
21 hydroxylase deficiency(21OHD) patients are at high risk of developing metabolic *** dose of glucocorticoids is a crucial ***,the relationship of glucocoticoid therapy and potential metabolic disorders was rarely st...
详细信息
21 hydroxylase deficiency(21OHD) patients are at high risk of developing metabolic *** dose of glucocorticoids is a crucial ***,the relationship of glucocoticoid therapy and potential metabolic disorders was rarely studied.32 treated and 31 untreated 21OHD patients were ***
Aim:The aim of this study was to investigate the relationship of the common carotid artery(CCA) intima-media thickness (IMT) with both albuminuria and eGFR(estimated glomeralar filtration rate) among the Chinese patie...
详细信息
Aim:The aim of this study was to investigate the relationship of the common carotid artery(CCA) intima-media thickness (IMT) with both albuminuria and eGFR(estimated glomeralar filtration rate) among the Chinese patients diagnosed with type 2 diabetes aged over 30.
Advanced glycation end products(AGEs) are elevated in aged and diabetic individuals and are associated with pathological changes associated with *** we demonstrated that AGEs induced increased reactive oxygen species(...
详细信息
Advanced glycation end products(AGEs) are elevated in aged and diabetic individuals and are associated with pathological changes associated with *** we demonstrated that AGEs induced increased reactive oxygen species(ROS) generation in INS-1 *** purpose of the present study was
Background:Thyroid nodules are extremely common, and epidemiological studies have shown that from 4 to 8%of the adult population have nonsymptomatic thyroid nodules that can palpated,and that 10--41%have thyroid nodul...
详细信息
Background:Thyroid nodules are extremely common, and epidemiological studies have shown that from 4 to 8%of the adult population have nonsymptomatic thyroid nodules that can palpated,and that 10--41%have thyroid nodules that can be detected by *** majority of thyroid nodules are
Aim:Diabetes mellitus is one of the most serious and challenging health problems in 2 1 st century and type 2 diabetes mellitus (T2DM)accounts 90%-95%of all *** insulin resistance and progressive pancreatic beta cell ...
详细信息
Aim:Diabetes mellitus is one of the most serious and challenging health problems in 2 1 st century and type 2 diabetes mellitus (T2DM)accounts 90%-95%of all *** insulin resistance and progressive pancreatic beta cell failure are considered key pathomechanisms in natural history of T2DM,but
环境内分泌干扰物(EEDs)是指环境中一类能够干扰生物体内源性激素的合成、释放、转运、结合或清除,从而影响机体的内环境、生殖的外源性物质.随着塑料餐具、不粘锅、化妆品、洗发剂、洗涤剂、家具中的各种黏合剂、阻燃剂、电子产品等广泛应用,EEDs在我们日常生活中无处不在,有报告显示中国人血清中某些EEDs浓度近年来增加非常显著.生殖系统是EEDs的高敏感靶器官之一,人群流行病学资料己证实大剂量EEDs暴露的生殖毒性,包括对对妇女妊娠能力及结局、子代产生不良影响的重要危险因素的研究.然而,以往研大多集中于2004年《斯德哥尔摩公约》定义的十二种传统的EEDs.近年来,诸如双酚A(BPA)和三氯生(Triclosan,TCS)一类的新型EEDs在日常生活中使用量不断增多,其在人体中的蓄积也逐渐上升.但有关此类EEDs对人类生殖的影响仍亟待人群调查和相应分子机制研究.旨在了解BPA和TCS对女性生殖道影响,我们收集并检测了304名单纯管性不孕的IVF-ET患者提供的219例尿液和281例卵泡液中BPA和TCS的浓度,分析(新鲜)胚胎移植患者的174份尿液和206份卵泡液中BPA和TCS浓度与其胚胎种植率的相关性;使用小鼠模型,研究BPA和TCS暴露与胚胎种植,子宫蜕膜化的相关性,分析了相关的分子机制.结果显示：患者尿液高BPA水平组胚胎种植率显著性低于尿液低BPA水平组(P=0.008);但是卵泡液中BPA水平与胚胎种植率无现显著性相关(P＞0.05);尿液和卵泡液中TCS浓度与种植率均无显著相关性(P＞0.05).小鼠模型显示：种植前(embryo day 0.5-3.5)灌胃环境相关剂量的BPA或TCS均可导致种植点数目剂量依赖性下降;环境相关剂量BPA或TCS灌胃小鼠蜕膜化的子宫重量增加低于对照组(P＜0.05),并显著影响母鼠子宫血管生成.机制研究表明BPA可通过下调子宫上皮细胞SGK1和ENaC α的影响小鼠子宫内膜蜕膜化,其可能通过雌激素途径发挥作用.结论：BPA和TCS暴露可以抑制母鼠子宫内膜蜕膜化及其血管生成.其中BPA可能通过雌激素受体通路,影响SGK1/ENaCα表达,进而影响IVF胚胎种植.
Objective:to report the clinical sympotom,hormone level ,pituitary and adrenal radiographic of one case ofACTH microadenoma patient who was treated by Paeireotide,and discuss the status quo and tendency of drug treatm...
详细信息
Objective:to report the clinical sympotom,hormone level ,pituitary and adrenal radiographic of one case ofACTH microadenoma patient who was treated by Paeireotide,and discuss the status quo and tendency of drug treatment on Cushing disease.
暂无评论