Objective:To study the function of alpha and delta cells of islet and the correlation between C-peptide,glucagon and somatostatin in aged type 2 diabetic patients and health people. Method:60 type 2 diabetic patients...
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Objective:To study the function of alpha and delta cells of islet and the correlation between C-peptide,glucagon and somatostatin in aged type 2 diabetic patients and health people. Method:60 type 2 diabetic patients（TDM group,age: 68.73 + 7.09y） and 54 normal people（normal control group,age: 67.55 + 6.24y） were enrolled in this *** samples were collected at fasting（0h） and postprandial（2h） after taking oral glucose tolerance test（OGTT） with *** blood glucose, C-peptide（C-P）,glucagon,somatostatin（SS） was assayed at these two time points.
Objective:To investigate the effects and possible molecular mechanisms of leukemia related protein 16(LRP16) gene on insulin sensitivity in 3T3-L1 adipocytes. Methods:(1)The LRP 16 gene over-expressing adipocyte cell ...
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Objective:To investigate the effects and possible molecular mechanisms of leukemia related protein 16(LRP16) gene on insulin sensitivity in 3T3-L1 adipocytes. Methods:(1)The LRP 16 gene over-expressing adipocyte cell line 3T3-L1-LRP16 and its control cell line 3T3-L1-3.1 were constructed using lipidosome transfection *** fulldifferentiated above adipocytes were pretreated with or without
Fulminant type 1 diabetes mellitus(T1DM) and drug hypersensitivity syndrome(DHS) are rare and life-threatening *** T1DM may develop after DHS with only few previous case reports and the possible role of human herpes v...
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Fulminant type 1 diabetes mellitus(T1DM) and drug hypersensitivity syndrome(DHS) are rare and life-threatening *** T1DM may develop after DHS with only few previous case reports and the possible role of human herpes virus 6(HHV-6) infection was indicated in the *** here presents three cases of fulminant T1DM developed shortly after the diagnosis of drug-induced hyper-sensitivity *** offending drugs were identified as Cefadroxil,cefuroxime and phenylbutazone *** of them were treated with high dose of glucocorticoids when hyper-glycemia symptoms occurred abruptly with rapid progression to *** terms of immunological parameters,one patient was positive for both GADA and ZnT8A,and had haplotypes of DQA1*0601-DQB1*0301/DQA1*0601-DQB1**** second one had positive GADA and DQA1*0102-DQB1*0601 /DQA1*05-DQB1*0201 *** third patient was negative for all autoantibodies tested and had haplotypes of DQA1*03-DQB1*0302/DQA1*03-DQB1**** HHV-6 virus antibodies were not detected in these patients,we found herpes simplex virus type 1 IgM antibodies(HSV1 IgM) positive in one and Coxsackie virus IgM antibodies(CVB IgM) positive in another *** understanding of the pathogenesis of fulminant T1DM will be improved if the relationship among DHS,glucocorticoids and virus infection can be clarified. More attention shoule be given to this novel and serious complication of patients with DHS.
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