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稳定期冠心病患者心理健康及生活满意状况调查

稳定期冠心病患者心理健康及生活满意状况调查

引用

2014浙江省医学会精神病学分会学术年会、浙江省医师协会精神科医师分会第七届年会

作者：吴月静吴万振王磊于恩彦浙江医院浙江省人民医院

冠心病（CHD）是常见心身疾病之一,心理因素对CHD的发生、发展、转轨及康复都具有影响。本研究旨在调查稳定期冠心病患者心理健康及生活满意状况,并探讨影响患者生活满意状况的心理因素。对2011年9月至2012年9月在我院心脏康复科门诊及... 详细信息

冠心病（CHD）是常见心身疾病之一,心理因素对CHD的发生、发展、转轨及康复都具有影响。本研究旨在调查稳定期冠心病患者心理健康及生活满意状况,并探讨影响患者生活满意状况的心理因素。对2011年9月至2012年9月在我院心脏康复科门诊及住院治疗,符合诊断标准的CHD康复期患者进行SCL-90、SF-36问卷调查,共入组219人（男119人,女90人）,年龄77.38±11.95岁。运用SPSS 16.0软件包,分别以t检验、x检验、方差分析、多元逐步回归等方法进行数据分析,采取双侧检验,以P<0.05为检验标准。结果发现CHD患者SCL-90总分131.17±24.98稍高于全国成年人常模的SCL-90总分129.96±38.76（P>0.05）,躯体化症状分1.81±0.48显著高于全国常模和杭州常模（分别为1.37±0.48和1.74±0.43）,其他心理症状评分（如强迫、人际关系敏感、抑郁、焦虑、敌对、精神病性症状等）在与两个常模的比较中存在不一致性。CHD患者SF-36总分均值为43.41±12.67分,以患者性别、年龄、学历、婚姻状况、既往病史及SCL-90各心理症状分经多元逐步回归逐步拟合,得出回归方程SF-36总分=114.88-10.36×躯体化-12.32×抑郁-9.73×敌对-0.26×年龄。方程的复相关系数R为0.809,校正相关系数平方为0.649,P<0.001。本研究表明躯体化症状是CHD患者心理健康状况不良的最突出表现,老年CHD患者对人际关系敏感、抑郁等症状的感知和评价能力较低年龄段成年人可能有所下降或不足,低年龄段的CHD患者存在更严重的心理健康不良的状况。本研究还发现,CHD患者存在普遍的生活质量下降,BP、PF、RE、RP、GH等因子分别在不同性别、年龄、婚姻状况及既往史的CHD患者中存在显著差异。CHD患者躯体化、抑郁、敌对等心理症状以及患者的年龄4个因素能够解释患者SF-36生活质量量表总分80.9%的变异度,躯体化、抑郁、敌对症状越严重,CHD患者生活质量状况则越差。该结论提示改善患者躯体化、抑郁、敌对等心理症状,可能提高CHD患者生活质量,增加慢性病治疗的满意度。

关键词： CHD 心理健康状况冠心病患者 SCL 精神病性症状患者生活质量既往史状况调查

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康复工疗对慢性精神分裂症患者阴性症状、认知功能和社会功能的影响

康复工疗对慢性精神分裂症患者阴性症状、认知功能和社会功能的影...

引用

2014浙江省医学会精神病学分会学术年会、浙江省医师协会精神科医师分会第七届年会

作者：陈远岭温亚平刘家洪黄文武温州康宁医院

目的了解药物结合康复工疗对慢性精神分裂症患者阴性症状、认知功能和社会功能改善的作用。方法将温州康宁医院精神科病房的300例慢性精神分裂症患者随机分为研究组(药物治疗结合康复工疗)和对照组(药物治疗),每组各150例。患者在入组... 详细信息

目的了解药物结合康复工疗对慢性精神分裂症患者阴性症状、认知功能和社会功能改善的作用。方法将温州康宁医院精神科病房的300例慢性精神分裂症患者随机分为研究组(药物治疗结合康复工疗)和对照组(药物治疗),每组各150例。患者在入组时、入组后12周及随访半年时应用阴性症状量表(SANS)、韦氏成人智力测验(WAIS)、个人和社会功能量表(PSP)进行评估。康复工疗前后计量资料采用配对样本t检验进行统计;组间计量资料采用独立样本t检验;计数资料应用卡方检验,随访资料采用重复测量的方差分析。结果(1)治疗12周及随访半年时,研究组SANS总分与入组时比较差异有统计学意义(t=7.74,F=11.32,均P<0.01);对照组SANS差异无统计学意义(均P>0.05)。研究组和对照组SANS评分的组间比较:入组时评分比较无明显差异(t=1.76,P>0.05);二组具有可比性;治疗12周及随访半年时二组比较有显著差异(t=6.76,t=8.12,均P<0.01)。(2)治疗12周及随访半年时,研究组WAIS总分增加,认知功能改善,差异有统计学意义(t=5.31,P<0.05;F=8.17,P<0.01)。对照组WAIS总分增加不明显,差异无统计学意义(均P>0.05)。二组的组间比较:入组时二组WAIS评分比较无明显差异(t=2.05,P>0.05),二组具有可比性;治疗12周及随访半年时二组比较有显著差异(t=3.87,t=5.23,均P<0.05)。(3)经过12周的康复工疗,在入组后12周及随访半年时,研究组PSP总分增加,社会功能改善,差异有统计学意义(t=4.81,P<0.05;F=10.54,P<0.01)。对照组PSP总分增加不明显,差异无统计学意义(均P>0.05)。二组的组间比较:入组时二组PSP评分比较无明显差异(t=1.24,P>0.05);治疗12周及随访半年时二组比较有显著差异(t=5.37,P<0.05;t=9.36,P<0.01)。结论药物治疗结合康复工疗的模式可使慢性精神分裂症患者的阴性症状减少,认知功能和社会功能较治疗前提高。

关键词：精神分裂症康复工疗认知功能社会功能

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Regional Brain Metabolic Alterations and Correlation between Clinical Scale Scores and Endocrine Disorders in Anorexia Nervosa Patients

Regional Brain Metabolic Alterations and Correlation between...

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2014浙江省医学会精神病学分会学术年会、浙江省医师协会精神科医师分会第七届年会

作者： Zheng Lin Yunrong Lu Lisha Shen Lei Xu Department of Psychiatry The Second Affiliated HospitalMedical School of Zhejiang University Department of Geriatric Diseases The Second Affiliated HospitalMedical School of Zhejiang University

Objectives:Anorexia nervosa(AN) is a psychiatric disorder with a high prevalence and mortality *** brain metabolic changes in AN patients have not been analyzed yet,and study focusing on specific correlation between functional changes in brain and the clinical states is *** study is to investigate these ***:Brian glucose metabolism in 11 AN patients and 11 age- and gender-matched healthy subjects was *** parametric mapping 2(SPM2) was used to compare brain metabolism in the two groups.9 of 11 patients completed the clinical scales.10 of 11 patients were selected to measure hormones in *** significant correlation was found between metabolic changes and clinical ***:Using the SPM2 analysis,higher metabolic changes were found in bilateral frontal lobe,bilateral parietal lobe,left occipital lobe,left temporal lobe,left anterior cingulate,right subcallosal gyrus and right *** broad correlation was found between metabolic changes and clinical indexes,both negatively and ***:This study confirmed that body image disturbance is the core of AN,indicated several brain regions involved in endocrine disorders in AN,and revealed that cerebellum tonsil is also participated in AN.

关键词： anorexia nervosa glucose metabolism clinical scales endocrine disorder

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缓解期精神分裂症ToM应用障碍的认知机制研究

缓解期精神分裂症ToM应用障碍的认知机制研究

引用

2014浙江省医学会精神病学分会学术年会、浙江省医师协会精神科医师分会第七届年会

作者：汪永光江小英王奕權梁燕施剑飞汪凯

背景:精神分裂症患者的心理理论损害(Theory of Mind,以下简称ToM)已得到广泛的证实。我们之前从ToM认知两阶段加工模型出发,对精神分裂症患者的ToM理解加工和ToM应用加工进行了独立的测查,结果显示缓解期精神分裂症患者ToM理解加工能... 详细信息

背景:精神分裂症患者的心理理论损害(Theory of Mind,以下简称ToM)已得到广泛的证实。我们之前从ToM认知两阶段加工模型出发,对精神分裂症患者的ToM理解加工和ToM应用加工进行了独立的测查,结果显示缓解期精神分裂症患者ToM理解加工能力相对完好,而ToM应用功能存在损害(Wang et ***,2013)。该研究结果支持了我们关于ToM两阶段分离的理论假设,然而缓解期精神分裂症患者的ToM应用障碍的认知机制尚不清楚。鉴于研究缓解期精神分裂症患者ToM应用障碍的认知机制能为精神分裂症患者社会认知与社会功能的长期康复策略提供重要参考,为此本研究中我们设计了一种新的试验范式一观点采择转换指令交流任务(perspective-taking-switching referential communication task)来探索缓解期精神分裂症患者ToM应用障碍的认知机制。方法:共有23名缓解期的精神分裂症患者进入本研究并完成观点采择转换指令交流任务。观点采择转换指令交流任务中要求研究对象根据虚拟人物给定的指令完成相应的选择任务。实验中共有两位虚拟人物(视角与被试相同或不同),通过对指令来源的操作控制视角转换变量(视角转换VS视角重复);通过对指令执行阶段干扰信息的操作(有干扰或无干扰)控制抑制加工水平变量(高抑制VS低抑制)。结果:正确率的重复测量方差分析结果显示,抑制加工水平变量的主效应显著(F=11.88,P<0.01),低抑制试次的正确率显著高于高抑制试次;视角转换变量的主效应接近显著水平(F=4.40,P=0.05),视角重复试次的正确率低于视角转换试次;抑制加工水平变量和视角转换变量的交互效应不显著(F=1.93,P=0.18)。正确反应时的重复测量方差分析结果显示,抑制加工水平变量的主效应显著(F=25.42,P<0.01),低抑制试次的正确反应时显著大于高抑制试次;视角转换变量的主效应接近显著水平(F=5.87,P=0.02),视角重复试次的正确反应时显著低于视角转换试次;抑制加工水平变量和视角转换变量的交互效应不显著(F=1.76,P=0.20)。结论:缓解期精神分裂症患者的ToM应用障碍与其抑制功能损害关系最为密切,同样也与其视角转换能力的损害有关。未来缓解期精神分裂症社会认知与社会功能康复计划中应设计视角转换能力训练和抑制冲突控制训练的内容。

关键词：缓解期精神分裂症精神分裂症患者主效应社会认知 ToM 应用障碍

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A cross-sectional study on perception of stigma by chinese schizophrenia patients

A cross-sectional study on perception of stigma by chinese s...

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2014浙江省医学会精神病学分会学术年会、浙江省医师协会精神科医师分会第七届年会

作者： Zhibin ren heqiu Wang Bin Feng chenyu gu Yongchun Ma hong chen lanying liu Department of Psychiatry Tongde hospitalZhejiang Chinese Medical University

Objective:In this cross-sectional study,we sought to assess the extent of internalized stigma among inpatients and outpatients with schizophrenia in the People s Republic of China and to investigate whether education level correlated with the experience of ***:Schizophrenia patients were evaluated using the Brief Psychiatric Rating Scale(BPRS),the Positive and Negative Syndrome Scale(PANSS),the Clinical Global Impressions-Severity of Illness(CGI-S) scale and the Stigma Scale for Mental Illness(SSMIC).Patients were categorized into high education and low education groups,according to their educational ***:One hundred thirty-three subjects were included in the *** mean course of illness was 4.32 ± 6.14 years(range:1 month to 15 years).Their mean BPRS score was 19.87 ± 5.46,their mean PANSS score was 44.11 ± 13.1,and their mean CGI-S score was 2.22 ± *** addition,their mean SSMI-C score was 6.49 ± *** mean SSMI-C score of patients who have received high school education or above was7.15 ± 0.98,which was markedly higher than that of patients who have received middle school education or below,which was 5.75 ± 0.79(P,0.05).Before the study most patients(92.5%,123/133) took atypical ***:Education level impacts on the perception of stigma by schizophrenia patients,and more psychoeducation should be undertaken to improve patients knowledge about schizophrenia.

关键词： schizophrenia stigma Brief Psychiatric Rating Scale(BPRS) Positive and Negative Syndrome Scale(PANSS) Clinical Global Impression-Severity(CGI-S) scale Stigma Scale for Mental Illness(SSMI-C)

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Early improvement predicts 8-week treatment outcome in patients with generalized anxiety disorder treated with Escitalopram or Venlafaxine

Early improvement predicts 8-week treatment outcome in patie...

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2014浙江省医学会精神病学分会学术年会、浙江省医师协会精神科医师分会第七届年会

作者： Mincai Qian Zhongxia Shen Min Lin Tiefeng Guan Jianhong Yang Liang Li Xinhua shen Yonggui Yuan Department of Neurosis and Psychosomatic Diseases.Huzhou Third Municipal Hospital Department of Neuropsychiatry Affiliated ZhongDa Hospital Medical School of Southeast University

Objective To investigate whether early improvement can predict 8-week treatment outcome in patients with generalized anxiety disorder(GAD) treated with escitalopram or *** 226 GAD patients were randomly assigned to receive either escitalopram or venlafaxine for 8 *** severity of the disease was evaluated with Hamilton anxiety rating scale(HAMA) and Hamilton depression rating scale(HAMD) at baseline and at the end of the 1st,2ed,4th,and 8th week,*** improvement was defined as a ≧ 20%reduction from baseline in HAMA score at week 1 or 2,remission as the HAMA score of ￡7,response as a≧ 50%reduction from baseline in HAMA score,and nonresponse as a <50%reduction from baseline in HAMA score,*** sensitivity,specificity,positive predictive value,and negative predictive value were *** In escitalopram-treated patients,the positive and negative predictive value of the early improvement at week 1 were 85.19%and 67.53%,and that at week 2 were 53.75%and 79.17%;In venlafaxine-treated patients,the positive and negative predictive value of the early improvement at week 1 were 84.62%and 65.33%,and that at week 2 were 59.21%and 88.00%,*** The early improvement achieved within the first week of escitalopram or venlafaxine treatment can predict a good 8-week treatment outcome in GAD patients.

关键词： Generalized anxiety disorder escitalopram venlafaxine efficacy early improvement

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Prevalence of tardive dyskinesia in chronic male inpatients with schizophrenia on long term clozapine versus typical antipsychotics

Prevalence of tardive dyskinesia in chronic male inpatients ...

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2014浙江省医学会精神病学分会学术年会、浙江省医师协会精神科医师分会第七届年会

作者： Minjie Ye Wei Tang Linjing Liu Feixue Zhang Jiahong Liu Yuanling Chen Da Chun Chen Mei Hong Xiu Li Hui Yun Long Tan Fu De Yang Jair C.Soares Xiang Yang Zhang Kangning Hospital Beijing HuiLongGuan Hospital Peking University Department of Psychiatry and Behavioral Sciences The University of Texas Health Science Center at Houston

This study aimed to examine the prevalence and clinical correlates of tardive dyskinesia(TD) in a large sample of Chinese inpatients with schizophrenia on long-term treatment with clozapine versus typical *** hundred and eighty-four male inpatients with schizophrenia on long-term clozapine(n=341) or typical antipsychotic(n=243) treatment were evaluated with the abnormal involuntary movement scale(AIMS).The patient s psychopathology was assessed using the Positive and Negative Syndrome Scale(PANSS).The overall TD prevalence was 44.5%,with rates of 48.7%in the clozapine group and 38.7%in the typical antipsychotic group(p=0.017).The AIMS score was significantly lower in typical than in clozapine groups(p<0.005).A multiple regression analysis showed that the following variables were significandy associated with the AIMS score:clozapine vs typical medication(p=0.008),PANSS negative subscore(p=0.017) and age(p=0.04).There are significant differences in the prevalence and clinical correlates of TD in schizophrenia treated with clozapine versus typical antipsychotics.

关键词： Tardive dyskinesia Clozapine Prevalence

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Study on the executive function of attention in depression patients based on SPECT technology

Study on the executive function of attention in depression p...

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2014浙江省医学会精神病学分会学术年会、浙江省医师协会精神科医师分会第七届年会

作者： Xiaoyi Li Hao Wu Cen Lou Baoping Xing Enyan Yu Department of Psychiatry and Mental Health Tongde Hospital of Zhejiang Province Department of Psychiatry and Mental Health Affiliated Sir Run Run Shaw HospitalMedical School of Zhejiang University Sir Run Run Shaw Institute Clinical Medicine of Zhejiang University Department of Nuclear Medicine Sir Run Run Shaw HospitalZhejiang University School of Medicine The People's Hospitalof Zhejiang Province

Objective:To investigate event-related potential in executive function of attention and characteristics of cerebral perfusion by99mTc-ECD single-photon emission computed tomography(SPECT) in depression patients receiving the Oddball ***:A total of 30 depression patients and 30 normal control subjects were selected to carry out the Oddball *** potential(ERP) technology combined with SPECT imaging technology was used to compare the reaction time,ERP-P300 latency and amplitude,and cerebral perfusion characteristics on sites of ***:Compared with normal control group,when the Oddball task was performed,the reaction time or ERP-P300 latency was not significantly different in depression patients(P> 0.05),but P300 amplitude on F3 and F7 sites increased significantly(t = 2.241,2.245,respectively;each P <0.05).SPECT showed cerebral hypoperfusion in the right basal ganglia,left frontal lobe and temporal lobe of depression ***:During the Oddball task,the P300 amplitude on F3 and F7 sites increased significantly in depression patients,who also showed cerebral hypoperfusion in the right basal ganglia,left frontal lobe and temporal *** result suggests that depression patients have brain region functional abnormalities involving attention execution and implicit memory processing during auditory channel information processing.

关键词： depression Oddball task P300 executive function of attention SPECT

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The Effect of Acupuncture of Soothing-Liver and Nourishing-Heart Method on Early Onset of SSRIs Treating Depressive Disorder and Related Indicators of Neuroimmunology

The Effect of Acupuncture of Soothing-Liver and Nourishing-H...

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2014浙江省医学会精神病学分会学术年会、浙江省医师协会精神科医师分会第七届年会

作者： Yi Liu Hui Feng Yali Mo Jingfang Gao Hongjing Mao Mingfen Song Shengdong Wang Yan Yin Wenjuan Liu Department of Psychiatry Seventh People's Hospital of Hangzhou Department of Gastroenterology Hangzhou Red Cross Hospital Department of Mental Health Zhejiang Provincial Hospital of Traditional Chinese Medicine

Objective:To observe acupuncture of soothing-liver and nourishing-heart method intervene the effect of early onset of selective serotonin reuptake inhibitors(SSRIs) treating depressive disorder and related indicators of ***:126 patients with depressive disorder were randomly divided into the drug group and the acupuncture-drug group,who were treated for 6 consecutive weeks,the two groups respectively in the different treatment time points were evaluated by MontgomeryAsberg Depression Rating Scale(MADRS) and Rating Scale for Side Effects(SERS) to assess acupuncture of soothing-liver and nourishing-heart method intervening the effects of early onset of SSRIs treating depressive disorder,and found the changes between the drug group and the acupuncture-drug group in serum 5-hydroxytryptamine(5-HT) and inflammatory cytokines before and after ***:MADRS score of 1,2,4,6 weekend after treatment,the acupuncture-drug group was significantly lower compared to the drug group(P<0.01).SERS score of 1,2,4,6 weekend after treatment,the acupuncture group were significantly lower compared to the drug group(P <0.01).At 6 weekend after treatment,serum 5-HT of the acupuncture-drug group was significantly higher compared to the drug group(P <0.01),pro-inflammatory cytokines interleukin-6(IL-6) of the acupuncture-drug group was significantly lower compared to the drug group(P <0.01),interleukin-lbeta(IL-1(3) of the acupuncture-drug was no statistical difference compared to the drug group(P >0.05),and anti-inflammatory cytokines interleukin-4(IL-4),interleukin-10(IL-10) of the acupuncture-drug group was significantly higher compared to the drug group(P <0.01,P < 0.05).Conclusion:Acupuncture of soothing-liver and nourishing-heart method could effectively accelerate the effects of early onset of SSRIs treating depressive disorder and significantly reduce the adverse reactions of SSRIs,moreover enhance serum 5-HTand regulate the balance of pro-inflammatory cy

关键词： Acupuncture Soothing-Liver and Nourishing-Heart Method Early Onset SSRIs Depressive Disorder 5-HT Inflammatory Cytokines

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